Tertiary prevention strategies for micrometastatic lymph node cervical cancer: A systematic review and a prototype of an adapted model of care
Language English Country Netherlands Media print-electronic
Document type Journal Article, Systematic Review
PubMed
38527594
DOI
10.1016/j.critrevonc.2024.104329
PII: S1040-8428(24)00072-6
Knihovny.cz E-resources
- Keywords
- Algorithm, Cervical cancer, Micrometastasis, Prevention, Review, Sentinel lymph node,
- MeSH
- Humans MeSH
- Neoplasm Recurrence, Local prevention & control pathology MeSH
- Lymphatic Metastasis * MeSH
- Lymph Nodes pathology MeSH
- Neoplasm Micrometastasis * pathology MeSH
- Uterine Cervical Neoplasms * pathology diagnosis prevention & control MeSH
- Prognosis MeSH
- Tertiary Prevention methods MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Systematic Review MeSH
PURPOSE: We found a need for balancing the application of clinical guidelines and tailored approaches to follow-up of cervical cancer (CC) patients in the lymph node micrometastatic (MICs) setting. This review aimed to determine the current knowledge of management of MIC-positive CC cases. METHODOLOGY: We addressed prognostic and risk of recurrence monitoring impacts associated with MIC+ cases. The electronic databases for literature and relevant articles were analysed. RESULTS: Fifteen studies, (4882 patients), were included in our systematic review. While the results show that MICs significantly worsen prognosis in early CC. A tertiary prevention algorithm for low volume lymph node disease may stratify follow-up according to the burden of nodal disease and provide data that helps improve follow-up performance. CONCLUSION: MICs worsen prognosis and should be managed as suggested by the algorithm. However, this algorithm must be externally validated. The clinical impact of isolated tumor cells (ITC) remains unclear.
Breast Gynaecology and Reconstructive Surgery Unit Institute Curie Paris France
Clinical Department of Gynaecology and Obstetrics City Hospital Rzeszów Rzeszów Poland
Department of Environmental Technology Faculty of Chemistry University of Gdańsk Gdańsk Poland
Department of Family Medicine Lazarski University Warsaw Poland
Department of Gynaecological Surgery Hospital Tenon Paris France
Department of Gynaecology and Obstetrics Medical University of Gdańsk Gdańsk Poland
Department of Gynaecology Oncology Michele e Pietro Ferrero Hospital Verduno Italy
Department of Pathology Medical University of Gdańsk Gdańsk Poland
Department of Surgery Institute Curie University Paris Cite Paris France
Hospital of Fribourg HFR Chemin des Pensionnats 2 6 Villars sur Glâne 1752 Switzerland
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