BACKGROUND: Maintaining healthy brain function during ageing is of great importance, especially for the self-sufficiency of older adults. The main aim of this study was to determine the effects of dance and martial arts on exerkines Brain Derived Neurotrophic Factor (BDNF) and irisin blood serum levels. METHODS: This randomized controlled trial examined the effects of dance and martial arts on serum Brain-Derived Neurotrophic Factor (BDNF) and irisin levels, as well as cognitive function, mood, and physical measures in older adults. Seventy-seven independently living older adults (mean age 70.3±3.8 years) were randomized into three groups: dance (DG), martial arts (MaG), and control (CG), followed over 12 weeks. Generalized linear models were used to assess the interventions' effects. RESULTS: There was a significant increase in BDNF levels in both the DG (1.8 ± 4.9, p < 0.05) and MaG (3.5 ± 6.3, p < 0.05), while CG experienced a decrease (-4.9 ± 8.2, p < 0.05). Between-group effects were significant for BDNF, with DG and MaG showing higher levels than CG (p < 0.05). No significant changes in irisin levels were found. Cognitive performance, particularly attention and mental flexibility (measured by the Trail Making Test A and B), significantly improved in the DG compared to CG (p < 0.05). Additionally, participants in DG showed improved mood based on the Geriatric Depression Scale (p < 0.05) compared to CG. Anthropometric T-scores were significantly associated with changes in irisin levels (p < 0.05) after intervention. CONCLUSION: The study found that dance and martial arts upregulated BDNF levels, with dance showing notable improvements in cognitive function and mood in older adults. Changes in anthropometric measures were linked to increased irisin levels. These findings suggest that both dance and martial arts may promote healthy brain function in aging populations. TRIAL REGISTRATION: NCT05363228.

3rd Faculty of Medicine Charles University Department of Neurology Prague Czech Republic

Department of Sports Dietetics Poznan University of Physical Education Poznań 61 871 Poland

Faculty of Physical Education and Sport Charles University Prague Czech Republic

University Hospital Kralovske Vinohrady Department of Neurology Prague Czech Republic

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Ahlskog JE. Does vigorous exercise have a neuroprotective effect in Parkinson disease? Neurology. 2011;77(3):288–294. doi:10.1212/WNL.0b013e318225ab66 PubMed DOI PMC

Arida RM, Cavalheiro EA, da Silva AC, Scorza FA. Physical activity and epilepsy: proven and predicted benefits. Sports Med. 2008;38(7):607–615. doi:10.2165/00007256-200838070-00006 PubMed DOI

Buchman AS, Boyle PA, Yu L, Shah RC, Wilson RS, Bennett DA. Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology. 2012;78(17):1323–1329. doi:10.1212/WNL.0b013e3182535d35 PubMed DOI PMC

Zhang Q, Wu Y, Zhang P, et al. Exercise induces mitochondrial biogenesis after brain ischemia in rats. Neuroscience. 2012;205:10–17. doi:10.1016/j.neuroscience.2011.12.053 PubMed DOI

Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003;14(2):125–130. doi:10.1111/1467-9280.t01-1-01430 PubMed DOI

Heo J, Noble EE, Call JA. The role of exerkines on brain mitochondria: a mini-review. J Appl Physiol. 2023;134(1):28–35. doi:10.1152/japplphysiol.00565.2022 PubMed DOI PMC

Knaepen K, Goekint M, Heyman EM, Meeusen R. Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects. Sports Med. 2010;40(9):765–801. doi:10.2165/11534530-000000000-00000 PubMed DOI

Bostrom P, Wu J, Jedrychowski MP, et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481(7382):463–468. doi:10.1038/nature10777 PubMed DOI PMC

Dun SL, Lyu RM, Chen YH, Chang JK, Luo JJ, Dun NJ. Irisin-immunoreactivity in neural and non-neural cells of the rodent. Neuroscience. 2013;240:155–162. doi:10.1016/j.neuroscience.2013.02.050 PubMed DOI PMC

Erickson KI, Voss MW, Prakash RS, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A. 2011;108(7):3017–3022. doi:10.1073/pnas.1015950108 PubMed DOI PMC

Wrann CD, White JP, Salogiannnis J, et al. Exercise induces hippocampal BDNF through a PGC-1alpha/FNDC5 pathway. Cell Metab. 2013;18(5):649–659. doi:10.1016/j.cmet.2013.09.008 PubMed DOI PMC

Lopez-Ortiz S, Lista S, Valenzuela PL, et al. Effects of physical activity and exercise interventions on Alzheimer’s disease: an umbrella review of existing meta-analyses. J Neurol. 2023;270(2):711–725. doi:10.1007/s00415-022-11454-8 PubMed DOI

Batson G. Update on proprioception: considerations for dance education. J Dance Med Sci. 2009;13(2):35–41. doi:10.1177/1089313X0901300201 PubMed DOI

Spanos K. Kinesthetic empathy in creative and cultural practices. Theatre Surv. 2014;55(2):264–266. doi:10.1017/S0040557414000131 DOI

Woodward TW. A review of the effects of martial arts practice on health. WMJ. 2009;108(1):40–43. PubMed

Brown S, Martinez MJ, Parsons LM. The neural basis of human dance. Cereb Cortex. 2006;16(8):1157–1167. doi:10.1093/cercor/bhj057 PubMed DOI

Sandel SL. Movement therapy with geriatric patients in a convalescent home. Hosp Community Psychiatry. 1978;29(11):738–741. doi:10.1176/ps.29.11.738 PubMed DOI

Fink B, Bläsing B, Ravignani A, Shackelford TK. Evolution and functions of human dance. Evol Hum Behav. 2021;42(4):351–360. doi:10.1016/j.evolhumbehav.2021.01.003 DOI

Muinos M, Ballesteros S. Does dance counteract age-related cognitive and brain declines in middle-aged and older adults? A systematic review. Neurosci Biobehav Rev. 2021;121:259–276. doi:10.1016/j.neubiorev.2020.11.028 PubMed DOI

Porto FHG, Tusch ES, Fox AM, Alperin BR, Holcomb PJ, Daffner KR. One of the most well-established age-related changes in neural activity disappears after controlling for visual acuity. Neuroimage. 2016;130:115–122. doi:10.1016/j.neuroimage.2016.01.035 PubMed DOI PMC

Solianik R, Mickeviciene D, Zlibinaite L, Cekanauskaite A. Tai chi improves psycho-emotional state, cognition, and motor learning in older adults during the COVID-19 pandemic. Exp Gerontol. 2021;150:111363. doi:10.1016/j.exger.2021.111363 PubMed DOI PMC

Wayne PM, Walsh JN, Taylor-Piliae RE, et al. Effect of tai chi on cognitive performance in older adults: systematic review and meta-analysis. J Am Geriatr Soc. 2014;62(1):25–39. doi:10.1111/jgs.12611 PubMed DOI PMC

Fong Yan A, Nicholson LL, Ward RE, et al. The effectiveness of dance interventions on psychological and cognitive health outcomes compared with other forms of physical activity: a systematic review with meta-analysis. Sports Med. 2024;54(5):1179–1205. doi:10.1007/s40279-023-01990-2 PubMed DOI PMC

Predovan D, Julien A, Esmail A, Bherer L. Effects of dancing on cognition in healthy older adults: a systematic review. J Cogn Enhanc. 2019;3(2):161–167. doi:10.1007/s41465-018-0103-2 PubMed DOI PMC

Tommasini E, Cipriani E, Antonietti A, Galvani C. Correlations between physical activity level, quality of life, and cognitive performance in elderly individuals engaging in multi-year dance activities. J Dance Med Sci. 2022;26(1):34–40. doi:10.12678/1089-313X.031522e PubMed DOI

Rodziewicz-Flis EA, Kawa M, Kaczor JJ, et al. Changes in selected exerkines concentration post folk-dance training are accompanied by glucose homeostasis and physical performance improvement in older adults. Sci Rep. 2023;13(1):8596. doi:10.1038/s41598-023-35583-w PubMed DOI PMC

Topolski TD, LoGerfo J, Patrick DL, Williams B, Walwick J, Patrick MB. The rapid assessment of physical activity (RAPA) among older adults. Prev Chronic Dis. 2006;3(4):A118. PubMed PMC

Galvin JE, Roe CM, Powlishta KK, et al. The AD8: a brief informant interview to detect dementia. Neurology. 2005;65(4):559–564. doi:10.1212/01.wnl.0000172958.95282.2a PubMed DOI

Faul F, Erdfelder E, Lang A-G, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175–191. doi:10.3758/BF03193146 PubMed DOI

Kattenstroth JC, Kalisch T, Holt S, Tegenthoff M, Dinse HR. Six months of dance intervention enhances postural, sensorimotor, and cognitive performance in elderly without affecting cardio-respiratory functions. Front Aging Neurosci. 2013;5:5. doi:10.3389/fnagi.2013.00005 PubMed DOI PMC

WHO. WHO Guidelines on Physical Activity and Sedentary Behaviour: At a Glance. Geneva: World Health Organization; 2020.

Lippi G, Salvagno GL, Montagnana M, Lima-Oliveira G, Guidi GC, Favaloro EJ. Quality standards for sample collection in coagulation testing. Semin Thromb Hemost. 2012;38(6):565–575. doi:10.1055/s-0032-1315961 PubMed DOI

Tuck MK, Chan DW, Chia D, et al. Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working group. J Proteome Res. 2009;8(1):113–117. doi:10.1021/pr800545q PubMed DOI PMC

Bean J. Rey Auditory Verbal Learning Test, Rey AVLT. In: Kreutzer JS, DeLuca J, Caplan B editors, Encyclopedia of Clinical Neuropsychology. edn ed. New York: Springer New York; 2011:2174–2175.doi:10.1007/978-0-387-79948-3_1153 DOI

Bezdicek O, Stepankova H, Motak L, et al. Czech version of rey auditory verbal learning test: normative data. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2014;21(6):693–721. doi:10.1080/13825585.2013.865699 PubMed DOI

Rey A. L’examen psychologique dans les cas d’encéphalopathie traumatique. (Les problems.). Arch Psychol. 1941;28:215–285. French.

Thurstone LL. Primary mental abilities. Science. 1948;108(2813):585. PubMed

Preiss M, Rodriguez M, Kawaciukowa R, Laing H. Neuropsychological Battery of Psychiatric Prague Center: Clinical Assessment of Basic Cognitive Functions. Praha, Czech Republic: Psychiatricke centrum Praha; 2007.

Kaufman AS, Lichtenberger EO. Assessing Adolescent and Adult Intelligence. Wiley; 2005.

Lezak MD, Howieson DB, Hannay HJ, Loring DW, Fischer JS. Neuropsychological Assessment. Oxford University Press; 2004.

Bowie CR, Harvey PD. Administration and interpretation of the trail making test. Nat Protoc. 2006;1(5):2277–2281. doi:10.1038/nprot.2006.390 PubMed DOI

Preiss M, Bartos A, Čermáková R, et al. Neuropsychological Battery of the Psychiatric Prague Center: Clinical Examinations of Major Cognitive Functions. Prague: Psychiatrické centrum; 2012.

Reitan RM. Validity of the trail making test as an indicator of organic brain damage. Percept Mot Skills. 1958;8(3):271–276. doi:10.2466/pms.1958.8.3.271 DOI

Lesher EL, Berryhill JS. Validation of the geriatric depression scale-short form among inpatients. J Clin Psychol. 1994;50(2):256–260. doi:10.1002/1097-4679(199403)50:2<256::aid-jclp2270500218>3.0.co;2-e PubMed DOI

Pfeffer RI, Kurosaki TT, Harrah CH Jr, Chance JM, Filos S. Measurement of functional activities in older adults in the community. J Gerontol. 1982;37(3):323–329. doi:10.1093/geronj/37.3.323 PubMed DOI

Baumgartner RN, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998;147(8):755–763. doi:10.1093/oxfordjournals.aje.a009520 PubMed DOI

Maggio M, Ceda GP, Ticinesi A, et al. Instrumental and non-instrumental evaluation of 4-meter walking speed in older individuals. PLoS One. 2016;11(4):e0153583. doi:10.1371/journal.pone.0153583 PubMed DOI PMC

Guralnik JM, Ferrucci L, Pieper CF, et al. Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol a Biol Sci Med Sci. 2000;55(4):M221–231. doi:10.1093/gerona/55.4.m221 PubMed DOI

Chow LS, Gerszten RE, Taylor JM, et al. Exerkines in health, resilience and disease. Nat Rev Endocrinol. 2022;18(5):273–289. doi:10.1038/s41574-022-00641-2 PubMed DOI PMC

Jodeiri Farshbaf M, Alvina K. Multiple roles in neuroprotection for the exercise derived myokine irisin. Front Aging Neurosci. 2021;13:649929. doi:10.3389/fnagi.2021.649929 PubMed DOI PMC

Lourenco MV, Frozza RL, de Freitas GB, et al. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nat Med. 2019;25(1):165–175. doi:10.1038/s41591-018-0275-4 PubMed DOI PMC

Jandova T, Buendia-Romero A, Polanska H, et al. Long-term effect of exercise on irisin blood levels-systematic review and meta-analysis. Healthcare. 2021;9(11). doi:10.3390/healthcare9111438 PubMed DOI PMC

Miyamoto-Mikami E, Sato K, Kurihara T, et al. Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults. PLoS One. 2015;10(3):e0120354. doi:10.1371/journal.pone.0120354 PubMed DOI PMC

Kim HJ, Lee HJ, So B, Son JS, Yoon D, Song W. Effect of aerobic training and resistance training on circulating irisin level and their association with change of body composition in overweight/obese adults: a pilot study. Physiol Res. 2016;65(2):271–279. doi:10.33549/physiolres.932997 PubMed DOI

Norheim F, Langleite TM, Hjorth M, et al. The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in humans. FEBS J. 2014;281(3):739–749. doi:10.1111/febs.12619 PubMed DOI

Pekkala S, Wiklund PK, Hulmi JJ, et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? J Physiol. 2013;591(21):5393–5400. doi:10.1113/jphysiol.2013.263707 PubMed DOI PMC

Tommasini E, Missaglia S, Vago P, et al. The time course of irisin release after an acute exercise: relevant implications for health and future experimental designs. Eur J Transl Myol. 2024;34(2). doi:10.4081/ejtm.2024.12693 PubMed DOI PMC

Cosio PL, Crespo-Posadas M, Velarde-Sotres A, Pelaez M. Effect of chronic resistance training on circulating irisin: systematic review and meta-analysis of randomized controlled trials. Int J Environ Res Public Health. 2021;18(5):2476. doi:10.3390/ijerph18052476 PubMed DOI PMC

Mohammad Rahimi GR, Hejazi K, Hofmeister M. The effect of exercise interventions on Irisin level: a systematic review and meta-analysis of randomized controlled trials. Excli J. 2022;21:524–539. doi:10.17179/excli2022-4703 PubMed DOI PMC

Motahari Rad M, Bijeh N, Attarzadeh Hosseini SR, Raouf Saeb A. The impact of different modes of exercise training on irisin: a systematic review and meta-analysis research. J Adv Med Biomed Res. 2021;29:125–138. doi:10.30699/jambs.29.134.125 DOI

Uusi-Rasi K, Sievanen H, Vuori I, et al. Long-term recreational gymnastics, estrogen use, and selected risk factors for osteoporotic fractures. J Bone Miner Res. 1999;14(7):1231–1238. doi:10.1359/jbmr.1999.14.7.1231 PubMed DOI

Nicolini C, Michalski B, Toepp SL, et al. A single bout of high-intensity interval exercise increases corticospinal excitability, brain-derived neurotrophic factor, and uncarboxylated osteocalcin in sedentary, healthy males. Neuroscience. 2020;437:242–255. doi:10.1016/j.neuroscience.2020.03.042 PubMed DOI

Chen X, Gan L. An exercise-induced messenger boosts memory in Alzheimer’s disease. Nat Med. 2019;25(1):20–21. doi:10.1038/s41591-018-0311-4 PubMed DOI

Vints WAJ, Levin O, Fujiyama H, Verbunt J, Masiulis N. Exerkines and long-term synaptic potentiation: mechanisms of exercise-induced neuroplasticity. Front Neuroendocrinol. 2022;66:100993. doi:10.1016/j.yfrne.2022.100993 PubMed DOI

Kujach S, Chroboczek M, Jaworska J, et al. Judo training program improves brain and muscle function and elevates the peripheral BDNF concentration among the elderly. Sci Rep. 2022;12(1):13900. doi:10.1038/s41598-022-17719-6 PubMed DOI PMC

Cho SY, Roh HT. Taekwondo enhances cognitive function as a result of increased neurotrophic growth factors in elderly women. Int J Environ Res Public Health. 2019;16(6):962. doi:10.3390/ijerph16060962 PubMed DOI PMC

Marinus N, Hansen D, Feys P, Meesen R, Timmermans A, Spildooren J. The impact of different types of exercise training on peripheral blood brain-derived neurotrophic factor concentrations in older adults: a meta-analysis. Sports Med. 2019;49(10):1529–1546. doi:10.1007/s40279-019-01148-z PubMed DOI

Dinoff A, Herrmann N, Swardfager W, et al. The effect of exercise training on resting concentrations of peripheral brain-derived neurotrophic factor (BDNF): a meta-analysis. PLoS One. 2016;11(9):e0163037. doi:10.1371/journal.pone.0163037 PubMed DOI PMC

Pareja-Galeano H, Alis R, Sanchis-Gomar F, et al. Methodological considerations to determine the effect of exercise on brain-derived neurotrophic factor levels. Clin Biochem. 2015;48(3):162–166. doi:10.1016/j.clinbiochem.2014.11.013 PubMed DOI

Molendijk ML, Haffmans JP, Bus BA, et al. Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight. PLoS One. 2012;7(11):e48046. doi:10.1371/journal.pone.0048046 PubMed DOI PMC

Lee P, Linderman JD, Smith S, et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab. 2014;19(2):302–309. doi:10.1016/j.cmet.2013.12.017 PubMed DOI PMC

Serra MP, Poddighe L, Boi M, et al. Effect of acute stress on the expression of BDNF, trkB, and PSA-NCAM in the hippocampus of the roman rats: a genetic model of vulnerability/resistance to stress-induced depression. Int J Mol Sci. 2018;19(12):3745. doi:10.3390/ijms19123745 PubMed DOI PMC

Guzman-Garcia A, Hughes JC, James IA, Rochester L. Dancing as a psychosocial intervention in care homes: a systematic review of the literature. Int J Geriatr Psychiatry. 2013;28(9):914–924. doi:10.1002/gps.3913 PubMed DOI

Vankova H, Holmerova I, Machacova K, Volicer L, Veleta P, Celko AM. The effect of dance on depressive symptoms in nursing home residents. J Am Med Dir Assoc. 2014;15(8):582–587. doi:10.1016/j.jamda.2014.04.013 PubMed DOI

Podolski OS, Whitfield T, Schaaf L, et al. The impact of dance movement interventions on psychological health in older adults without dementia: a systematic review and meta-analysis. Brain Sci. 2023;13(7):981. doi:10.3390/brainsci13070981 PubMed DOI PMC

Teixeira-Machado L, Arida RM, de Jesus Mari J. Dance for neuroplasticity: a descriptive systematic review. Neurosci Biobehav Rev. 2019;96:232–240. doi:10.1016/j.neubiorev.2018.12.010 PubMed DOI

Muller P, Duderstadt Y, Lessmann V, Muller NG. Lactate and BDNF: key mediators of exercise induced neuroplasticity? J Clin Med. 2020;9(4):1136. doi:10.3390/jcm9041136 PubMed DOI PMC

Svensson M, Lexell J, Deierborg T. Effects of physical exercise on neuroinflammation, neuroplasticity, neurodegeneration, and behavior: what we can learn from animal models in clinical settings. Neurorehabil Neural Repair. 2015;29(6):577–589. doi:10.1177/1545968314562108 PubMed DOI

Vilela TC, Muller AP, Damiani AP, et al. Strength and aerobic exercises improve spatial memory in aging rats through stimulating distinct neuroplasticity mechanisms. Mol Neurobiol. 2017;54(10):7928–7937. doi:10.1007/s12035-016-0272-x PubMed DOI

Planella-Farrugia C, Comas F, Sabater-Masdeu M, et al. Circulating irisin and myostatin as markers of muscle strength and physical condition in elderly subjects. Front Physiol. 2019;10:871. doi:10.3389/fphys.2019.00871 PubMed DOI PMC

Colaianni G, Oranger A, Dicarlo M, et al. Irisin serum levels and skeletal muscle assessment in a cohort of Charcot-Marie-tooth patients. Front Endocrinol. 2022;13:886243. doi:10.3389/fendo.2022.886243 PubMed DOI PMC

Baek JY, Jang IY, Jung HW, et al. Serum irisin level is independent of sarcopenia and related muscle parameters in older adults. Exp Gerontol. 2022;162:111744. doi:10.1016/j.exger.2022.111744 PubMed DOI

Gomez-Pinilla F, Hillman C. The influence of exercise on cognitive abilities. Compr Physiol. 2013;3(1):403–428. doi:10.1002/cphy.c110063 PubMed DOI PMC

Xia DY, Huang X, Bi CF, Mao LL, Peng LJ, Qian HR. PGC-1alpha or FNDC5 is involved in modulating the effects of Aβ1−42 oligomers on suppressing the expression of BDNF, a beneficial factor for inhibiting neuronal apoptosis, Aβ deposition and cognitive decline of APP/PS1 Tg mice. Front Aging Neurosci. 2017;9:65. doi:10.3389/fnagi.2017.00065 PubMed DOI PMC

Zoladz JA, Pilc A, Majerczak J, Grandys M, Zapart-Bukowska J, Duda K. Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men. J Physiol Pharmacol. 2008;59(7):119–132. PubMed

Guilherme J, Semenova EA, Borisov OV, et al. The BDNF-increasing allele is associated with increased proportion of fast-twitch muscle fibers, handgrip strength, and power athlete status. J Strength Cond Res. 2022;36(7):1884–1889. doi:10.1519/JSC.0000000000003756 PubMed DOI

Clow C, Jasmin BJ. Brain-derived neurotrophic factor regulates satellite cell differentiation and skeletal muscle regeneration. Mol Biol Cell. 2010;21(13):2182–2190. doi:10.1091/mbc.e10-02-0154 PubMed DOI PMC

Renteria I, Garcia-Suarez PC, Fry AC, et al. The molecular effects of BDNF synthesis on skeletal muscle: a mini-review. Front Physiol. 2022;13:934714. doi:10.3389/fphys.2022.934714 PubMed DOI PMC

Brigola AG, Rossetti ES, Dos Santos BR, et al. Relationship between cognition and frailty in elderly: a systematic review. Dement Neuropsychol. 2015;9(2):110–119. doi:10.1590/1980-57642015DN92000005 PubMed DOI PMC

Pieruccini-Faria F, Lord SR, Toson B, Kemmler W, Schoene D. Mental flexibility influences the association between poor balance and falls in older people - a secondary analysis. Front Aging Neurosci. 2019;11:133. doi:10.3389/fnagi.2019.00133 PubMed DOI PMC

Basso JC, Satyal MK, Rugh R. Dance on the brain: enhancing intra- and inter-brain synchrony. Front Hum Neurosci. 2020;14:584312. doi:10.3389/fnhum.2020.584312 PubMed DOI PMC

Menezes AC, Drumond G, Shigaeff N. Dance therapy and cognitive impairment in older people: a review of clinical data. Dement Neuropsychol. 2022;16(4):373–383. doi:10.1590/1980-5764-DN-2021-0103 PubMed DOI PMC

Ma C, Li M, Li R, Wu C. The effect of rhythmic movement on physical and cognitive functions among cognitively healthy older adults: a systematic review and meta-analysis. Arch Gerontol Geriatr. 2023;104:104837. doi:10.1016/j.archger.2022.104837 PubMed DOI

Rehfeld K, Luders A, Hokelmann A, et al. Dance training is superior to repetitive physical exercise in inducing brain plasticity in the elderly. PLoS One. 2018;13(7):e0196636. doi:10.1371/journal.pone.0196636 PubMed DOI PMC

FGdM C, Gobbi S, Andreatto CAA, Corazza DI, Pedroso RV, Santos-Galduróz RF. Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF): a systematic review of experimental studies in the elderly. Arch Gerontol Geriatr. 2013;56(1):10–15. doi:10.1016/j.archger.2012.06.003 PubMed DOI

Esmail A, Vrinceanu T, Lussier M, et al. Effects of dance/movement training vs. aerobic exercise training on cognition, physical fitness and quality of life in older adults: a randomized controlled trial. J Bodyw Mov Ther. 2020;24(1):212–220. doi:10.1016/j.jbmt.2019.05.004 PubMed DOI

Brehmer Y, Kalpouzos G, Wenger E, Lovden M. Plasticity of brain and cognition in older adults. Psychol Res. 2014;78(6):790–802. doi:10.1007/s00426-014-0587-z PubMed DOI

Pascual-Leone A, Amedi A, Fregni F, Merabet LB. The plastic human brain cortex. Annu Rev Neurosci. 2005;28:377–401. doi:10.1146/annurev.neuro.27.070203.144216 PubMed DOI

Toril P, Reales JM, Ballesteros S. Video game training enhances cognition of older adults: a meta-analytic study. Psychol Aging. 2014;29(3):706–716. doi:10.1037/a0037507 PubMed DOI

Vaportzis E, Niechcial MA, Gow AJ. A systematic literature review and meta-analysis of real-world interventions for cognitive ageing in healthy older adults. Ageing Res Rev. 2019;50:110–130. doi:10.1016/j.arr.2019.01.006 PubMed DOI

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