Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study
Status PubMed-not-MEDLINE Language English Country United States Media electronic-ecollection
Document type Journal Article
Grant support
P41 EB027061
NIBIB NIH HHS - United States
R00 EB016689
NIBIB NIH HHS - United States
K23 NS104211
NINDS NIH HHS - United States
P30 NS076408
NINDS NIH HHS - United States
R01 NS133305
NINDS NIH HHS - United States
R61 NS118651
NINDS NIH HHS - United States
R01 NS128478
NINDS NIH HHS - United States
R21 EB031211
NIBIB NIH HHS - United States
R01 NS109450
NINDS NIH HHS - United States
K24 NS126781
NINDS NIH HHS - United States
K01 EB030039
NIBIB NIH HHS - United States
R03 NS139000
NINDS NIH HHS - United States
K01 NS105160
NINDS NIH HHS - United States
L30 NS108301
NINDS NIH HHS - United States
R01 NS109114
NINDS NIH HHS - United States
R01 EB027779
NIBIB NIH HHS - United States
PubMed
40800833
PubMed Central
PMC12319740
DOI
10.1162/imag_a_00559
PII: imag_a_00559
Knihovny.cz E-resources
- Keywords
- body height and weight, brain, in vivo human neuroimaging, intracranial volume, spinal cord, structural magnetic resonance imaging,
- Publication type
- Journal Article MeSH
Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject's sex and age. However, corrections for body size (i.e., height and weight) are mostly lacking in clinical neuroimaging designs. This study investigates the importance of body size parameters in their relationship with spinal cord (SC) and brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population of 267 healthy human adults (age 30.1 ± 6.6 years old, 125 females). We show that body height correlates with brain gray matter (GM) volume, cortical GM volume, total cerebellar volume, brainstem volume, and cross-sectional area (CSA) of cervical SC white matter (CSA-WM; 0.44 ≤ r ≤ 0.62). Intracranial volume (ICV) correlates with body height (r = 0.46) and the brain volumes and CSA-WM (0.37 ≤ r ≤ 0.77). In comparison, age correlates with cortical GM volume, precentral GM volume, and cortical thickness (-0.21 ≥ r ≥ -0.27). Body weight correlates with magnetization transfer ratio in the SC WM, dorsal columns, and lateral corticospinal tracts (-0.20 ≥ r ≥ -0.23). Body weight further correlates with the mean diffusivity derived from diffusion tensor imaging (DTI) in SC WM (r = -0.20) and dorsal columns (-0.21), but only in males. CSA-WM correlates with brain volumes (0.39 ≤ r ≤ 0.64), and with precentral gyrus thickness and DTI-based fractional anisotropy in SC dorsal columns and SC lateral corticospinal tracts (-0.22 ≥ r ≥ -0.25). Linear mixture of age, sex, or sex and age, explained 2 ± 2%, 24 ± 10%, or 26 ± 10%, of data variance in brain volumetry and SC CSA. The amount of explained variance increased to 33 ± 11%, 41 ± 17%, or 46 ± 17%, when body height, ICV, or body height and ICV were added into the mixture model. In females, the explained variances halved suggesting another unidentified biological factor(s) determining females' central nervous system (CNS) morphology. In conclusion, body size and ICV are significant biological variables. Along with sex and age, body size should therefore be included as a mandatory variable in the design of clinical neuroimaging studies examining SC and brain structure; and body size and ICV should be considered as covariates in statistical analyses. Normalization of different brain regions with ICV diminishes their correlations with body size, but simultaneously amplifies ICV-related variance (r = 0.72 ± 0.07) and suppresses volume variance of the different brain regions (r = 0.12 ± 0.19) in the normalized measurements.
Aix Marseille Univ CNRS CRMBM Marseille France
APHM Hopital Universitaire Timone CEMEREM Marseille France
Canon Medical Systems srl Rome Italy
Centre de recherche du CHU Sainte Justine Université de Montréal Montreal QC Canada
Centre for Human Brain Health University of Birmingham Birmingham United Kingdom
Centre for Medical Image Computing University College London London United Kingdom
Clement J Zablocki Veteran's Affairs Medical Center Milwaukee WI United States
CREF Museo storico della fisica e Centro studi e ricerche Enrico Fermi Rome Italy
Department for Systems Neuroscience University Medical Center Hamburg Eppendorf Hamburg Germany
Department of Biomedical Engineering Vanderbilt University Nashville TN United States
Department of Biomedical Sciences Humanitas University Pieve Emanuele Italy
Department of Biophysics Faculty of Medicine Masaryk University Brno Czech Republic
Department of Brain and Behavioural Sciences University of Pavia Pavia Italy
Department of Neurological Surgery University of California Davis CA United States
Department of Neurology University Hospital Brno Brno Czech Republic
Department of Neurosurgery Medical College of Wisconsin Milwaukee WI United States
Department of Neurosurgery University of Oklahoma Oklahoma City OK United States
Department of Pathology and Laboratory Medicine University of British Columbia Vancouver BC Canada
Department of Physics and Astronomy University of British Columbia Vancouver BC Canada
Department of Psychiatry Baylor College of Medicine Houston TX United States
Department of Psychology University of Chinese Academy of Sciences Beijing China
Department of Radiology Baylor College of Medicine Houston TX United States
Department of Radiology Beijing Tiantan Hospital Capital Medical University Beijing China
Department of Radiology Faculty of Medicine University of British Columbia Vancouver BC Canada
Department of Radiology Juntendo University School of Medicine Bunkyo Tokyo Japan
Department of Radiology Northwestern University Chicago IL United States
Department of Radiology Swiss Paraplegic Centre Nottwil Switzerland
Department of Radiology Toho University Omori Medical Center Tokyo Japan
Division of Neurology Faculty of Medicine University of British Columbia Vancouver BC Canada
e Health Center Universitat Oberta de Catalunya Barcelona Spain
Faculty of Medicine Masaryk University Brno Czech Republic
Fondation Campus Biotech Geneva Genève Switzerland
Functional Neuroimaging Unit CRIUGM University of Montreal Montreal Canada
Harvard Medical School Boston MA United States
IBM Poland Department of Content Design Cracow Poland
Institute for Mental Health University of Birmingham Birmingham United Kingdom
Institute of Nanotechnology CNR Rome Italy
International Collaboration on Repair Discoveries University of British Columbia Vancouver BC Canada
IRCCS Santa Lucia Foundation Neuroimaging Laboratory Rome Italy
McConnell Brain Imaging Centre Montreal Neurological Institute McGill University Montreal QC Canada
Mila Quebec AI Institute Montreal QC Canada
MR Clinical Science Philips Healthcare Canada Mississauga Canada
Neuro 10 Institute Ecole polytechnique fédérale de Lausanne Geneva Switzerland
NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal QC Canada
Neuroradiology Unit IRCCS Humanitas Research Hospital Rozzano Italy
Stanford University Stanford CA United States
The University of Tokyo Hospital Radiology Center Tokyo Japan
Université de Strasbourg CNRS ICube Strasbourg France
Vall d'Hebron Institute of Oncology Vall d'Hebron Barcelona Hospital Campus Barcelona Spain
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