Discoidin Domain [diskoidinová doména]

topical
Terms

diskoidinové domény

 

Discoidin Domains

Persistent link   https://www.medvik.cz/link/D000070822
Definition

A protein domain originally identified in DISCOIDINS. It occurs in a variety of unrelated proteins in multicellular organisms, where it recognizes different ligands with distinct biological functions. Structurally, it consists of two antiparallel beta sheets that form a jellyroll configuration stabilized by two intramolecular disulfide bonds. Sequence differences within this module determine ligand specificity; in DISCOIDIN DOMAIN RECEPTORS, it binds to FIBRILLAR COLLAGENS and NON-FIBRILLAR COLLAGENS.

DUI
D000070822 MeSH Browser
CUI
M000612305
Previous indexing
Lectins (1998-2016); Protein Structure, Tertiary (1998-2016)
History note
2017
Public note
2017

Allowable subheadings

DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects

G Phenomena and Processes
G01 Physical Phenomena 81
G02 Chemical Phenomena 308
G02.111 Biochemical Phenomena 370
G02.111.570 Molecular Structure 1 339
G02.111.570.820 Molecular Conformation 228
G02.111.570.820.709 Protein Conformation 560
G02.111.570.820.709.275 Protein Structural Elements 1
G02.111.570.820.709.275.750 Protein Domains 180
G02.111.570.820.709.275.750.125 C2 Domains
G02.111.570.820.709.275.750.157 Carbohydrate Binding Modules
G02.111.570.820.709.275.750.188 Catalytic Domain 218
G02.111.570.820.709.275.750.219 Discoidin Domain
G02.111.570.820.709.275.750.235 HMG-Box Domains 2
G02.111.570.820.709.275.750.250 Immunoglobulin Domains 4
G02.111.570.820.709.275.750.375 Kringles 2
G02.111.570.820.709.275.750.438 Methyl CpG Binding Domain
G02.111.570.820.709.275.750.469 Pleckstrin Homology Domains 2
G02.111.570.820.709.275.750.477 PR-SET Domains
G02.111.570.820.709.275.750.485 Proline-Rich Protein Domains 3
G02.111.570.820.709.275.750.500 Protein Interaction Domains and Motifs 95
G03 Metabolism 1 203
G03 Metabolic Phenomena obsolete
G04 Cell Physiological Phenomena 515
G05 Genetic Phenomena 135
G06 Microbiological Phenomena 96
G07 Physiological Phenomena 176
G08 Reproductive and Urinary Physiological Phenomena 18
G09 Circulatory and Respiratory Physiological Phenomena 93
G10 Digestive System and Oral Physiological Phenomena 4
G11 Musculoskeletal and Neural Physiological Phenomena 17
G12 Immune System Phenomena 249
G13 Integumentary System Physiological Phenomena 14
G14 Ocular Physiological Phenomena 148
G15 Plant Physiological Phenomena 158
G16 Biological Phenomena 130
G17 Mathematical Concepts 66

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