Autophagy-Related Protein-1 Homolog [homolog Atg1]

topical
1
Terms

komplex ULK1
protein ULK1

 

Serine-Threonine Protein Kinase ULK1
ULK1 Protein
Unc-51 Like Autophagy Activating Kinase 1
Unc-51-Like Kinase 1

Persistent link   https://www.medvik.cz/link/D000071189
Definition

A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates.

DUI
D000071189 MeSH Browser
CUI
M000613481
Previous indexing
Protein-Serine-Threonine Kinases (1998-2016)
History note
2017
Public note
2017

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 1
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 551
D08.811.913 Transferases 72
D08.811.913.696 Phosphotransferases 69
D08.811.913.696.620 Phosphotransferases (Alcohol Group Acceptor) 32
D08.811.913.696.620.682 Protein Kinases 249
D08.811.913.696.620.682.700 Protein Serine-Threonine Kinases 273
D08.811.913.696.620.682.700.062 Activin Receptors 5
D08.811.913.696.620.682.700.074 AMP-Activated Protein Kinase Kinases 1
D08.811.913.696.620.682.700.085 AMP-Activated Protein Kinases 41
D08.811.913.696.620.682.700.097 Ataxia Telangiectasia Mutated Proteins 89
D08.811.913.696.620.682.700.103 Aurora Kinases 4
D08.811.913.696.620.682.700.108 Autophagy-Related Protein-1 Homolog 1
D08.811.913.696.620.682.700.109 Bone Morphogenetic Protein Receptors 3
D08.811.913.696.620.682.700.125 Calcium-Calmodulin-Dependent Protein Kinases 10
D08.811.913.696.620.682.700.140 Casein Kinases 1
D08.811.913.696.620.682.700.143 Checkpoint Kinase 1 20
D08.811.913.696.620.682.700.145 Checkpoint Kinase 2 50
D08.811.913.696.620.682.700.150 Cyclic Nucleotide-Regulated Protein Kinases
D08.811.913.696.620.682.700.250 DNA-Activated Protein Kinase 14
D08.811.913.696.620.682.700.275 Doublecortin-Like Kinases
D08.811.913.696.620.682.700.288 Dyrk Kinases
D08.811.913.696.620.682.700.300 eIF-2 Kinase 8
D08.811.913.696.620.682.700.364 G-Protein-Coupled Receptor Kinases 2
D08.811.913.696.620.682.700.397 Germinal Center Kinases 2
D08.811.913.696.620.682.700.429 Glycogen Synthase Kinases
D08.811.913.696.620.682.700.494 I-kappa B Kinase 9
D08.811.913.696.620.682.700.526 Interleukin-1 Receptor-Associated Kinases 3
D08.811.913.696.620.682.700.534 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 2
D08.811.913.696.620.682.700.542 Lim Kinases 2
D08.811.913.696.620.682.700.559 MAP Kinase Kinase Kinases 48
D08.811.913.696.620.682.700.565 Mitogen-Activated Protein Kinase Kinases 41
D08.811.913.696.620.682.700.567 Mitogen-Activated Protein Kinases 101
D08.811.913.696.620.682.700.576 Myotonin-Protein Kinase 2
D08.811.913.696.620.682.700.579 NF-kappaB-Inducing Kinase 1
D08.811.913.696.620.682.700.581 NIMA-Related Kinases 4
D08.811.913.696.620.682.700.586 Oncogene Protein v-akt 5
D08.811.913.696.620.682.700.596 p21-Activated Kinases 9
D08.811.913.696.620.682.700.606 Phytochrome A 2
D08.811.913.696.620.682.700.616 Polo-like Kinases
D08.811.913.696.620.682.700.626 Positive Transcriptional Elongation Factor B 4
D08.811.913.696.620.682.700.646 Proline-Directed Protein Kinases 1
D08.811.913.696.620.682.700.725 Protein Kinase C 138
D08.811.913.696.620.682.700.745 3-Phosphoinositide-Dependent Protein Kinases
D08.811.913.696.620.682.700.750 Protein Kinase D2
D08.811.913.696.620.682.700.755 Proto-Oncogene Proteins c-akt 120
D08.811.913.696.620.682.700.759 Proto-Oncogene Proteins c-bcr 19
D08.811.913.696.620.682.700.776 Proto-Oncogene Proteins c-pim-1 1
D08.811.913.696.620.682.700.783 Pyruvate Dehydrogenase Acetyl-Transferring Kinase 1
D08.811.913.696.620.682.700.789 Receptor, Transforming Growth Factor-beta Type I 2
D08.811.913.696.620.682.700.795 Receptor, Transforming Growth Factor-beta Type II
D08.811.913.696.620.682.700.801 Receptor-Interacting Protein Serine-Threonine Kinases 7
D08.811.913.696.620.682.700.814 rho-Associated Kinases 26
D08.811.913.696.620.682.700.862 Ribosomal Protein S6 Kinases 1
D08.811.913.696.620.682.700.897 Serine-Threonine Kinase 3
D08.811.913.696.620.682.700.931 TOR Serine-Threonine Kinases 196
D08.811.913.696.620.682.700.965 Vacuolar Sorting Protein VPS15
D08.811.913.696.620.682.700.982 WNK Lysine-Deficient Protein Kinase 1
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 581
D12.776.094 Autophagy-Related Proteins 7
D12.776.094.250 Autophagy-Related Protein 5 3
D12.776.094.391 Autophagy-Related Protein 12 1
D12.776.094.399 Autophagy-Related Protein 7
D12.776.094.407 Autophagy-Related Protein 8 Family 2
D12.776.094.438 Autophagy-Related Protein-1 Homolog 1
D12.776.094.500 Beclin-1 3
D12.776.094.750 Sequestosome-1 Protein 3
D12.776.476 Intracellular Signaling Peptides and Proteins 175
D12.776.476.563 Protein Serine-Threonine Kinases 273
D12.776.476.563.062 Activin Receptors 5
D12.776.476.563.074 AMP-Activated Protein Kinase Kinases 1
D12.776.476.563.085 AMP-Activated Protein Kinases 41
D12.776.476.563.097 Ataxia Telangiectasia Mutated Proteins 89
D12.776.476.563.103 Aurora Kinases 4
D12.776.476.563.108 Autophagy-Related Protein-1 Homolog 1
D12.776.476.563.109 Bone Morphogenetic Protein Receptors 3
D12.776.476.563.125 Calcium-Calmodulin-Dependent Protein Kinases 10
D12.776.476.563.140 Casein Kinases 1
D12.776.476.563.143 Checkpoint Kinase 1 20
D12.776.476.563.145 Checkpoint Kinase 2 50
D12.776.476.563.150 Cyclic Nucleotide-Regulated Protein Kinases
D12.776.476.563.250 DNA-Activated Protein Kinase 14
D12.776.476.563.275 Doublecortin-Like Kinases
D12.776.476.563.288 Dyrk Kinases
D12.776.476.563.300 eIF-2 Kinase 8
D12.776.476.563.364 G-Protein-Coupled Receptor Kinases 2
D12.776.476.563.397 Germinal Center Kinases 2
D12.776.476.563.429 Glycogen Synthase Kinases
D12.776.476.563.494 I-kappa B Kinase 9
D12.776.476.563.526 Interleukin-1 Receptor-Associated Kinases 3
D12.776.476.563.534 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 2
D12.776.476.563.542 Lim Kinases 2
D12.776.476.563.554 MAP Kinase Kinase Kinases 48
D12.776.476.563.565 Mitogen-Activated Protein Kinase Kinases 41
D12.776.476.563.567 Mitogen-Activated Protein Kinases 101
D12.776.476.563.576 Myotonin-Protein Kinase 2
D12.776.476.563.579 NF-kappaB-Inducing Kinase 1
D12.776.476.563.581 NIMA-Related Kinases 4
D12.776.476.563.586 Oncogene Protein v-akt 5
D12.776.476.563.596 p21-Activated Kinases 9
D12.776.476.563.606 Phytochrome A 2
D12.776.476.563.616 Polo-like Kinases
D12.776.476.563.626 Positive Transcriptional Elongation Factor B 4
D12.776.476.563.646 Proline-Directed Protein Kinases 1
D12.776.476.563.725 Protein Kinase C 138
D12.776.476.563.745 3-Phosphoinositide-Dependent Protein Kinases
D12.776.476.563.750 Protein Kinase D2
D12.776.476.563.755 Proto-Oncogene Proteins c-akt 120
D12.776.476.563.759 Proto-Oncogene Proteins c-bcr 19
D12.776.476.563.776 Proto-Oncogene Proteins c-pim-1 1
D12.776.476.563.783 Pyruvate Dehydrogenase Acetyl-Transferring Kinase 1
D12.776.476.563.789 Receptor, Transforming Growth Factor-beta Type I 2
D12.776.476.563.795 Receptor, Transforming Growth Factor-beta Type II
D12.776.476.563.801 Receptor-Interacting Protein Serine-Threonine Kinases 7
D12.776.476.563.814 rho-Associated Kinases 26
D12.776.476.563.862 Ribosomal Protein S6 Kinases 1
D12.776.476.563.897 Serine-Threonine Kinase 3
D12.776.476.563.931 TOR Serine-Threonine Kinases 196
D12.776.476.563.965 Vacuolar Sorting Protein VPS15
D12.776.476.563.982 WNK Lysine-Deficient Protein Kinase 1

Atg1 protein, Drosophila Chemical MeSH Browser

ULK1 protein, human Chemical MeSH Browser

ULK1 protein, rat Chemical MeSH Browser

Ulk1 protein, mouse Chemical MeSH Browser

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