N-Myc Proto-Oncogene Protein [protoonkogen n-myc]
topical
9
- Terms
-
BHLHE37 Protein
Class E Basic Helix-Loop-Helix Protein 37
MYCN Protein
N-Myc Protein
NMYC Protein
Persistent link
https://www.medvik.cz/link/D000071447
Definition
A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.
- DUI
- D000071447 MeSH Browser
- CUI
- M000614703
- Previous indexing
- Nuclear Proteins (2002-2016); Oncogene Proteins (2002-2016); Proto-Oncogene Proteins (2012-2016)
- History note
- 2017
- Public note
- 2017
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 0
- AG
- agonists 0
- AN
- analysis 0
- AI
- antagonists & inhibitors 1
- BI
- biosynthesis 0
- BL
- blood 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 0
- CL
- classification 0
- DF
- deficiency 0
- DE
- drug effects 0
- EC
- economics 0
- GE
- genetics 7
- HI
- history 0
- IM
- immunology 0
- IP
- isolation & purification 0
- ME
- metabolism 4
- PK
- pharmacokinetics 0
- PD
- pharmacology 0
- PH
- physiology 0
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 1
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 0
...
Occurrences in Medvik records
D
Chemicals and Drugs
D12.776.260.103.500.875
Transcription Factor 3
D12.776.260.108.092.875
Transcription Factor 3
D12.776.624.664.700.013
Axl Receptor Tyrosine Kinase
D12.776.624.664.700.112
Fibroblast Growth Factor 6
D12.776.624.664.700.119
KRIT1 Protein
D12.776.624.664.700.165
B-Cell Lymphoma 3 Protein
D12.776.624.664.700.177
Proto-Oncogene Proteins c-fes
D12.776.624.664.700.791
Receptor, ErbB-4
D12.776.624.664.700.815
Receptor, Notch4
D12.776.624.664.700.936
RUNX1 Translocation Partner 1 Protein
D12.776.624.664.700.960
T-Cell Acute Lymphocytic Leukemia Protein 1
D12.776.624.664.700.978
Wnt2 Protein
D12.776.930.125.500.875
Transcription Factor 3
D12.776.930.127.092.875
Transcription Factor 3