protein RUNX1T1 [RUNX1 Translocation Partner 1 Protein]

tematický
Termíny

Eight Twenty One Protein
RUNX1T1 Protein

Perzistentní odkaz   https://www.medvik.cz/link/D000075142
Definice

A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.

DUI
D000075142 MeSH Prohlížeč
CUI
M000629597
Předchozí užití
Transcription Factors (2008-2017); DNA-Binding Proteins (1993-2017); Proto-Oncogene Proteins (1993-2017)
Historická pozn.
2018
Veřejná pozn.
2018

Povolená podhesla

AG
agonisté 0
AN
analýza 0
AI
antagonisté a inhibitory 0
AD
aplikace a dávkování 0
BI
biosyntéza 0
CS
chemická syntéza 0
CH
chemie 0
HI
dějiny 0
EC
ekonomika 0
PK
farmakokinetika 0
PD
farmakologie 0
PH
fyziologie 0
GE
genetika 0
IM
imunologie 0
IP
izolace a purifikace 0
CL
klasifikace 0
BL
krev 0
ME
metabolismus 0
UR
moč 0
CF
mozkomíšní mok 0
DF
nedostatek 0
ST
normy 0
PO
otrava 0
AE
škodlivé účinky 0
TU
terapeutické užití 0
TO
toxicita 0
DE
účinky léků 0
RE
účinky záření 0
UL
ultrastruktura 0
SD
zásobování a distribuce 0

D Chemikálie a léčiva
D12 aminokyseliny, peptidy a proteiny 16
D12.776 proteiny 2 575
D12.776.624 nádorové proteiny 411
D12.776.624.664 onkogenní proteiny 125
D12.776.624.664.700 protoonkogenní proteiny 263
D12.776.624.664.700.013 tyrozinkinasový receptor AXL
D12.776.624.664.700.025 protein BCL2L11 5
D12.776.624.664.700.037 tyrosinkinasa c-Mer 2
D12.776.624.664.700.049 chemokin CXCL1 7
D12.776.624.664.700.100 cyklin D1 86
D12.776.624.664.700.110 fibroblastový růstový faktor 4 2
D12.776.624.664.700.112 fibroblastový růstový faktor 6
D12.776.624.664.700.114 tyrosinkinasa 3 podobná fms 49
D12.776.624.664.700.117 Janus kinasa 2 79
D12.776.624.664.700.119 protein KRIT1
D12.776.624.664.700.120 KLF6 1
D12.776.624.664.700.123 lipokalin-2 21
D12.776.624.664.700.128 tyrosinkinasa p56(lck), specifická pro lymfocyty 10
D12.776.624.664.700.129 protein MDS1 and EVI1 complex locus 2
D12.776.624.664.700.130 homolog 2 proteinu MutS 17
D12.776.624.664.700.148 protoonkogenní protein MLL 39
D12.776.624.664.700.158 protoonkogen n-myc 9
D12.776.624.664.700.163 pre-B-buněčný leukemický transkripční faktor 1 2
D12.776.624.664.700.165 protein bcl-3
D12.776.624.664.700.166 protoonkogen Mas 2
D12.776.624.664.700.167 protoonkogenní proteiny c-abl 7
D12.776.624.664.700.168 protoonkogenní proteiny c-akt 116
D12.776.624.664.700.169 protoonkogenní proteiny c-bcl-2 147
D12.776.624.664.700.170 protoonkogenní proteiny c-bcl-6 3
D12.776.624.664.700.171 protoonkogenní proteiny c-bcr 19
D12.776.624.664.700.172 protoonkogenní proteiny c-cbl 5
D12.776.624.664.700.174 protoonkogenní proteiny c-crk 1
D12.776.624.664.700.175 protoonkogenní proteiny c-ets 19
D12.776.624.664.700.177 protoonkogenní proteiny c-fes
D12.776.624.664.700.179 protoonkogenní proteiny c-fos 61
D12.776.624.664.700.180 protoonkogenní proteiny c-fyn 4
D12.776.624.664.700.181 protoonkogenní proteiny c-hck 1
D12.776.624.664.700.182 protoonkogenní proteiny c-jun 17
D12.776.624.664.700.183 protoonkogenní proteiny c-kit 77
D12.776.624.664.700.184 protoonkogenní proteiny c-maf 1
D12.776.624.664.700.185 protoonkogenní proteiny c-mdm2 65
D12.776.624.664.700.186 protoonkogenní proteiny c-met 30
D12.776.624.664.700.187 protoonkogenní proteiny c-mos 2
D12.776.624.664.700.188 protoonkogenní proteiny c-myb 30
D12.776.624.664.700.189 protoonkogenní proteiny c-myc 66
D12.776.624.664.700.191 protoonkogenní proteiny c-pim-1 1
D12.776.624.664.700.192 protoonkogenní proteiny c-rel 2
D12.776.624.664.700.194 protoonkogenní proteiny c-ret 42
D12.776.624.664.700.195 protoonkogenní proteiny c-sis 3
D12.776.624.664.700.198 protoonkogenní proteiny c-vav 4
D12.776.624.664.700.199 protoonkogenní proteiny c-yes 1
D12.776.624.664.700.200 protoonkogenní proteiny p21(ras) 71
D12.776.624.664.700.202 protoonkogenní proteiny pp60(c-src) 7
D12.776.624.664.700.204 raf kinasy 70
D12.776.624.664.700.642 receptor erbB-2 584
D12.776.624.664.700.790 receptor erbB-3 9
D12.776.624.664.700.791 receptor ErbB-4
D12.776.624.664.700.792 receptor fibroblastových růstových faktorů, typ 3 27
D12.776.624.664.700.800 receptor faktoru stimulujícího kolonie makrofágů 1
D12.776.624.664.700.815 receptor Notch4
D12.776.624.664.700.830 receptory thyreoidních hormonů 40
D12.776.624.664.700.913 protein EWS vázající RNA 15
D12.776.624.664.700.915 protein FUS vázající RNA 6
D12.776.624.664.700.936 protein RUNX1T1
D12.776.624.664.700.957 stathmin 4
D12.776.624.664.700.960 transkripční faktor TAL1
D12.776.624.664.700.962 protein Wnt 5a 5
D12.776.624.664.700.967 protein Wnt1 4
D12.776.624.664.700.978 protein Wnt2
D12.776.624.664.700.989 protein Gli1 7
D12.776.930 transkripční faktory 727
D12.776.930.780 represorové proteiny 189
D12.776.930.780.625 korepresorové proteiny 6
D12.776.930.780.625.186 sirotčí receptor DAX-1 3
D12.776.930.780.625.374 korepresor 1 jaderného receptoru 2
D12.776.930.780.625.400 korepresor 2 jaderného receptoru 4
D12.776.930.780.625.575 protein RUNX1T1
D12.776.930.780.625.750 histondeacetylasa Sin3 a korepresorový komplex

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