protoonkogen n-myc [N-Myc Proto-Oncogene Protein]

tematický
9
Termíny

BHLHE37 Protein
Class E Basic Helix-Loop-Helix Protein 37
MYCN Protein
N-Myc Protein
NMYC Protein

Perzistentní odkaz   https://www.medvik.cz/link/D000071447
Definice

A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.

DUI
D000071447 MeSH Prohlížeč
CUI
M000614703
Předchozí užití
Nuclear Proteins (2002-2016); Oncogene Proteins (2002-2016); Proto-Oncogene Proteins (2012-2016)
Historická pozn.
2017
Veřejná pozn.
2017

D Chemikálie a léčiva
D12.776 proteiny 2 575
D12.776.260 DNA vazebné proteiny 556
D12.776.260.103.500 transkripční faktory BHLH-Zip 31
D12.776.260.103.500.625 protoonkogen n-myc 9
D12.776.260.103.500.750 proteiny SREBP 2
D12.776.260.103.500.875 transkripční faktor 3
D12.776.260.108.092 transkripční faktory BHLH-Zip 31
D12.776.260.108.092.625 protoonkogen n-myc 9
D12.776.260.108.092.750 proteiny SREBP 2
D12.776.260.108.092.875 transkripční faktor 3
D12.776.260.108.092.937 transkripční faktor 4 6
D12.776.624 nádorové proteiny 411
D12.776.624.664 onkogenní proteiny 125
D12.776.624.664.700 protoonkogenní proteiny 263
D12.776.624.664.700.013 tyrozinkinasový receptor AXL
D12.776.624.664.700.025 protein BCL2L11 5
D12.776.624.664.700.037 tyrosinkinasa c-Mer 2
D12.776.624.664.700.049 chemokin CXCL1 7
D12.776.624.664.700.100 cyklin D1 86
D12.776.624.664.700.110 fibroblastový růstový faktor 4 2
D12.776.624.664.700.112 fibroblastový růstový faktor 6
D12.776.624.664.700.114 tyrosinkinasa 3 podobná fms 49
D12.776.624.664.700.117 Janus kinasa 2 79
D12.776.624.664.700.119 protein KRIT1
D12.776.624.664.700.120 KLF6 1
D12.776.624.664.700.123 lipokalin-2 21
D12.776.624.664.700.129 protein MDS1 and EVI1 complex locus 2
D12.776.624.664.700.130 homolog 2 proteinu MutS 17
D12.776.624.664.700.148 protoonkogenní protein MLL 39
D12.776.624.664.700.158 protoonkogen n-myc 9
D12.776.624.664.700.165 protein bcl-3
D12.776.624.664.700.166 protoonkogen Mas 2
D12.776.624.664.700.167 protoonkogenní proteiny c-abl 7
D12.776.624.664.700.168 protoonkogenní proteiny c-akt 116
D12.776.624.664.700.169 protoonkogenní proteiny c-bcl-2 147
D12.776.624.664.700.170 protoonkogenní proteiny c-bcl-6 3
D12.776.624.664.700.171 protoonkogenní proteiny c-bcr 19
D12.776.624.664.700.172 protoonkogenní proteiny c-cbl 5
D12.776.624.664.700.174 protoonkogenní proteiny c-crk 1
D12.776.624.664.700.175 protoonkogenní proteiny c-ets 19
D12.776.624.664.700.177 protoonkogenní proteiny c-fes
D12.776.624.664.700.179 protoonkogenní proteiny c-fos 61
D12.776.624.664.700.180 protoonkogenní proteiny c-fyn 4
D12.776.624.664.700.181 protoonkogenní proteiny c-hck 1
D12.776.624.664.700.182 protoonkogenní proteiny c-jun 17
D12.776.624.664.700.183 protoonkogenní proteiny c-kit 77
D12.776.624.664.700.184 protoonkogenní proteiny c-maf 1
D12.776.624.664.700.185 protoonkogenní proteiny c-mdm2 65
D12.776.624.664.700.186 protoonkogenní proteiny c-met 30
D12.776.624.664.700.187 protoonkogenní proteiny c-mos 2
D12.776.624.664.700.188 protoonkogenní proteiny c-myb 30
D12.776.624.664.700.189 protoonkogenní proteiny c-myc 66
D12.776.624.664.700.191 protoonkogenní proteiny c-pim-1 1
D12.776.624.664.700.192 protoonkogenní proteiny c-rel 2
D12.776.624.664.700.194 protoonkogenní proteiny c-ret 42
D12.776.624.664.700.195 protoonkogenní proteiny c-sis 3
D12.776.624.664.700.198 protoonkogenní proteiny c-vav 4
D12.776.624.664.700.199 protoonkogenní proteiny c-yes 1
D12.776.624.664.700.200 protoonkogenní proteiny p21(ras) 71
D12.776.624.664.700.202 protoonkogenní proteiny pp60(c-src) 7
D12.776.624.664.700.204 raf kinasy 70
D12.776.624.664.700.642 receptor erbB-2 584
D12.776.624.664.700.790 receptor erbB-3 9
D12.776.624.664.700.791 receptor ErbB-4
D12.776.624.664.700.815 receptor Notch4
D12.776.624.664.700.830 receptory thyreoidních hormonů 40
D12.776.624.664.700.913 protein EWS vázající RNA 15
D12.776.624.664.700.915 protein FUS vázající RNA 6
D12.776.624.664.700.936 protein RUNX1T1
D12.776.624.664.700.957 stathmin 4
D12.776.624.664.700.960 transkripční faktor TAL1
D12.776.624.664.700.962 protein Wnt 5a 5
D12.776.624.664.700.967 protein Wnt1 4
D12.776.624.664.700.978 protein Wnt2
D12.776.624.664.700.989 protein Gli1 7
D12.776.930 transkripční faktory 727
D12.776.930.125.500 transkripční faktory BHLH-Zip 31
D12.776.930.125.500.563 protoonkogen n-myc 9
D12.776.930.125.500.625 koaktivátor 1 jaderných receptorů 4
D12.776.930.125.500.750 proteiny SREBP 2
D12.776.930.125.500.875 transkripční faktor 3
D12.776.930.125.500.937 transkripční faktor 4 6
D12.776.930.127.092 transkripční faktory BHLH-Zip 31
D12.776.930.127.092.625 protoonkogen n-myc 9
D12.776.930.127.092.750 proteiny SREBP 2
D12.776.930.127.092.875 transkripční faktor 3