N-Myc Proto-Oncogene Protein [protoonkogen n-myc]
- Terms
-
BHLHE37 Protein
Class E Basic Helix-Loop-Helix Protein 37
MYCN Protein
N-Myc Protein
NMYC Protein
A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.
- DUI
- D000071447 MeSH Browser
- CUI
- M000614703
- Previous indexing
- Nuclear Proteins (2002-2016); Oncogene Proteins (2002-2016); Proto-Oncogene Proteins (2012-2016)
- History note
- 2017
- Public note
- 2017
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors 1
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics 7
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 4
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 1
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
MYCN protein, human Chemical MeSH Browser
MYCN protein, mouse Chemical MeSH Browser
Mycn protein, rat Chemical MeSH Browser