RUNX1 Translocation Partner 1 Protein [protein RUNX1T1]
topical
- Terms
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Eight Twenty One Protein
RUNX1T1 Protein
Persistent link
https://www.medvik.cz/link/D000075142
Definition
A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.
- DUI
- D000075142 MeSH Browser
- CUI
- M000629597
- Previous indexing
- Transcription Factors (2008-2017); DNA-Binding Proteins (1993-2017); Proto-Oncogene Proteins (1993-2017)
- History note
- 2018
- Public note
- 2018
Allowable subheadings
- AD
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- cerebrospinal fluid 0
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- chemical synthesis 0
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- chemistry 0
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- drug effects 0
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- economics 0
- GE
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- immunology 0
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- isolation & purification 0
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- metabolism 0
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- pharmacology 0
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Occurrences in Medvik records
D
Chemicals and Drugs
D12.776.624.664.700.013
Axl Receptor Tyrosine Kinase
D12.776.624.664.700.112
Fibroblast Growth Factor 6
D12.776.624.664.700.119
KRIT1 Protein
D12.776.624.664.700.165
B-Cell Lymphoma 3 Protein
D12.776.624.664.700.177
Proto-Oncogene Proteins c-fes
D12.776.624.664.700.791
Receptor, ErbB-4
D12.776.624.664.700.815
Receptor, Notch4
D12.776.624.664.700.936
RUNX1 Translocation Partner 1 Protein
D12.776.624.664.700.960
T-Cell Acute Lymphocytic Leukemia Protein 1
D12.776.624.664.700.978
Wnt2 Protein
D12.776.930.780.625.575
RUNX1 Translocation Partner 1 Protein
D12.776.930.780.625.750
Sin3 Histone Deacetylase and Corepressor Complex