Tripartite Motif-Containing Protein 28 [protein TRIM28]

topical
Terms

TRIM28 protein

 

TRIM28 Protein

Persistent link   https://www.medvik.cz/link/D000076183
Definition

A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.

DUI
D000076183 MeSH Browser
CUI
M000632418
Previous indexing
Repressor Proteins (2004-2017)
History note
2018
Public note
2018

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 551
D08.811.464 Ligases 33
D08.811.464.938 Ubiquitin-Protein Ligase Complexes 25
D08.811.464.938.750 Ubiquitin-Protein Ligases 81
D08.811.464.938.750.092 Anaphase-Promoting Complex-Cyclosome 12
D08.811.464.938.750.186 Fanconi Anemia Complementation Group L Protein 2
D08.811.464.938.750.210 Inhibitor of Apoptosis Proteins 29
D08.811.464.938.750.233 Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein 1
D08.811.464.938.750.257 Nedd4 Ubiquitin Protein Ligases
D08.811.464.938.750.280 Polycomb Repressive Complex 1 6
D08.811.464.938.750.374 Proto-Oncogene Proteins c-cbl 6
D08.811.464.938.750.562 Proto-Oncogene Proteins c-mdm2 65
D08.811.464.938.750.656 Receptors, Autocrine Motility Factor 1
D08.811.464.938.750.703 Seven in Absentia Proteins
D08.811.464.938.750.750 SKP Cullin F-Box Protein Ligases 14
D08.811.464.938.750.782 Tripartite Motif-Containing Protein 28
D08.811.464.938.750.813 Tumor Necrosis Factor alpha-Induced Protein 3 2
D08.811.464.938.750.875 Von Hippel-Lindau Tumor Suppressor Protein 31
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 581
D12.776.260 DNA-Binding Proteins 561
D12.776.260.703 Repressor Proteins 189
D12.776.260.703.099 AraC Transcription Factor
D12.776.260.703.200 COUP Transcription Factor II 1
D12.776.260.703.400 ETS Translocation Variant 6 Protein 1
D12.776.260.703.600 Lac Repressors 2
D12.776.260.703.650 Positive Regulatory Domain I-Binding Factor 1 2
D12.776.260.703.675 Tripartite Motif-Containing Protein 28
D12.776.260.703.700 Zinc Finger E-box Binding Homeobox 2 3
D12.776.260.703.800 Zinc Finger E-box-Binding Homeobox 1 6
D12.776.260.703.900 Zinc Finger Protein Gli3
D12.776.930 Transcription Factors 733
D12.776.930.780 Repressor Proteins 189
D12.776.930.780.500 AraC Transcription Factor
D12.776.930.780.563 CCCTC-Binding Factor 2
D12.776.930.780.625 Co-Repressor Proteins 6
D12.776.930.780.750 COUP Transcription Factor II 1
D12.776.930.780.766 ETS Translocation Variant 6 Protein 1
D12.776.930.780.781 Lac Repressors 2
D12.776.930.780.890 Polycomb-Group Proteins 7
D12.776.930.780.904 Positive Regulatory Domain I-Binding Factor 1 2
D12.776.930.780.911 Tripartite Motif-Containing Protein 28
D12.776.930.780.918 Zinc Finger E-box Binding Homeobox 2 3
D12.776.930.780.945 Zinc Finger E-box-Binding Homeobox 1 6
D12.776.930.780.972 Zinc Finger Protein Gli3
D12.776.934 Tripartite Motif Proteins 2
D12.776.934.500 Promyelocytic Leukemia Protein 4
D12.776.934.750 Pyrin
D12.776.934.875 Tripartite Motif-Containing Protein 28

TRIM28 protein, human Chemical MeSH Browser

Trim28 protein, mouse Chemical MeSH Browser

Trim28 protein, rat Chemical MeSH Browser

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