Zinc Finger Protein Gli3 [protein Gli3 s motivem zinkových prstů]
- Terms
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protein zinkových prstů Gli3
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GLI-Kruppel Family Member 3 Protein
Glioma-Associated Oncogene Family Zinc Finger 3 Protein
A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.
- DUI
- D000074290 MeSH Browser
- CUI
- M000625941
- Previous indexing
- DNA-Binding Proteins (1990-2017); Transcription Factors (1990-2017); Kruppel-Like Transcription Factors (2006-2017); Nerve Tissue Proteins (2006-2017)
- History note
- 2018
- Public note
- 2018
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
GLI3 protein, Xenopus Chemical MeSH Browser
GLI3 protein, human Chemical MeSH Browser
GLI3 protein, rat Chemical MeSH Browser
Gli3 protein, mouse Chemical MeSH Browser
Gli3 protein, zebrafish Chemical MeSH Browser