A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.

DUI

D000074290 MeSH Prohlížeč

CUI

M000625941

Předchozí užití

DNA-Binding Proteins (1990-2017); Transcription Factors (1990-2017); Kruppel-Like Transcription Factors (2006-2017); Nerve Tissue Proteins (2006-2017)

Historická pozn.

2018

Veřejná pozn.

2018