A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.

Annotation

/ defic = VON WILLEBRAND DISEASE or specific type of Von Willebrand Disease

DUI

D014841 MeSH Browser

CUI

M0022850

Previous indexing

Blood Platelets (1966-1974); Blood Coagulation Factors (1966-1974); von Willebrand's Disease (1966-1975)

History note

86(76); was see under BLOOD COAGULATION FACTORS 1976-85; FACTOR VIII RELATED ANTIGEN, previously in the Supplementary Chemical File, was mapped to both FACTOR VIII & ANTIGENS 1977-89

Online note

use FACTOR VIII & ANTIGENS to search FACTOR VIII RELATED ANTIGEN 1977-89

Public note

86; was see under BLOOD COAGULATION FACTORS 1976-85