von Willebrand Factor [von Willebrandův faktor]
- Terms
-
ristocetin kofaktor
vWF
-
Factor VIII-Related Antigen
Factor VIIIR-Ag
Factor VIIIR-RCo
Plasma Factor VIII Complex
Ristocetin Cofactor
Ristocetin-Willebrand Factor
von Willebrand Protein
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
- Annotation
- / defic = VON WILLEBRAND DISEASE or specific type of Von Willebrand Disease
- DUI
- D014841 MeSH Browser
- CUI
- M0022850
- Previous indexing
- Blood Platelets (1966-1974); Blood Coagulation Factors (1966-1974); von Willebrand's Disease (1966-1975)
- History note
- 86(76); was see under BLOOD COAGULATION FACTORS 1976-85; FACTOR VIII RELATED ANTIGEN, previously in the Supplementary Chemical File, was mapped to both FACTOR VIII & ANTIGENS 1977-89
- Online note
- use FACTOR VIII & ANTIGENS to search FACTOR VIII RELATED ANTIGEN 1977-89
- Public note
- 86; was see under BLOOD COAGULATION FACTORS 1976-85
Allowable subheadings
- AD
- administration & dosage 8
- AE
- adverse effects 3
- AG
- agonists
- AA
- analogs & derivatives
- AN
- analysis 25
- AI
- antagonists & inhibitors 2
- BI
- biosynthesis 2
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 5
- CL
- classification
- DE
- drug effects 3
- EC
- economics
- GE
- genetics 17
- HI
- history
- IM
- immunology 5
- IP
- isolation & purification 3
- ME
- metabolism 20
- PK
- pharmacokinetics 1
- PD
- pharmacology 2
- PH
- physiology 10
- PO
- poisoning
- RE
- radiation effects
- ST
- standards 1
- SD
- supply & distribution
- TU
- therapeutic use 19
- TO
- toxicity 1
- UL
- ultrastructure
- UR
- urine
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