An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.

DUI

D016590 MeSH Browser

CUI

M0025305

CAS

9,15-Cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3alpha,4alpha,5alpha,17alpha)-

Previous indexing

Antiviral Agents (1966-1991); Diterpenes (1974-1991); DNA Polymerases/antagonists & inhibitors (1977-1991)

History note

92; was APHIDICOLIN (NM) 1974-91

Online note

use APHIDICOLIN (NM) to search APHIDICOLIN 1980-91

Public note

92; APHIDICOLIN was indexed under DITERPENES 1974-91