NADPH Oxidases [NADPH-oxidasy]
- Terms
-
NAD(P)H-oxidasa
NAD(P)H-oxidáza
NADPH-oxidasa
NADPH-oxidáza
NADPH-oxidázy
-
NAD(P)H oxidase
NAD(P)H Oxidases
NADPH Oxidase
Nox Proteins
A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.
- DUI
- D019255 MeSH Browser
- CUI
- M0028676
- Previous indexing
- NADH, NADPH Oxidoreductases (1979-1996); NADP (1972-1980); Oxidoreductases (1972-1978)
- History note
- 2018 (1997)
- Public note
- 2018; see NADPH OXIDASE 1997-2017; NAD(P)H OXIDASE was indexed under NADH, NADPH OXIDOREDUCTASES 2000-2005; NADPH OXIDASE was indexed under NADH, NADPH OXIDOREDUCTASES 1979-1996, NADP 1972-1980 & OXIDOREDUCTASES 1972-1978
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects 1
- AN
- analysis
- AI
- antagonists & inhibitors 6
- BI
- biosynthesis 2
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects 1
- EC
- economics
- GE
- genetics 12
- HI
- history
- IM
- immunology 4
- IP
- isolation & purification
- ME
- metabolism 22
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology 6
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
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CYBA protein, human Chemical MeSH Browser
Cyba protein, mouse Chemical MeSH Browser
Cyba protein, rat Chemical MeSH Browser
NADPH-oxidase, Arabidopsis Chemical MeSH Browser
NCF2 protein, human Chemical MeSH Browser
NCF4 protein, human Chemical MeSH Browser
Ncf2 protein, mouse Chemical MeSH Browser
Nox protein, Drosophila Chemical MeSH Browser
Nox3 protein, human Chemical MeSH Browser
Nox3 protein, mouse Chemical MeSH Browser
Nox3 protein, rat Chemical MeSH Browser
RBOHH protein, Arabidopsis Chemical MeSH Browser
RBOHJ protein, Arabidopsis Chemical MeSH Browser
RbohF protein, Arabidopsis Chemical MeSH Browser
Rhd2 protein, Arabidopsis Chemical MeSH Browser
cytochrome b558 Chemical MeSH Browser
dual oxidase Udx1, sea urchin Chemical MeSH Browser
dual oxidase, Drosophila Chemical MeSH Browser
duox protein, zebrafish Chemical MeSH Browser
neutrophil cytosolic factor 1 Chemical MeSH Browser
respiratory burst oxidase 1, tomato Chemical MeSH Browser
superoxide-forming enzyme Chemical MeSH Browser