STAT Transcription Factors [transkripční faktory STAT]

topical
23
Terms

STAT (Signal Transducers and Activators of Transcription) Proteins

Persistent link   https://www.medvik.cz/link/D050791
Definition

A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.

Annotation
general; prefer specifics
DUI
D050791 MeSH Browser
CUI
M0477894
History note
2006
Public note
2006

Allowable subheadings

AD
administration & dosage 0
AE
adverse effects 0
AG
agonists 0
AN
analysis 0
AI
antagonists & inhibitors 1
BI
biosynthesis 0
BL
blood 0
CF
cerebrospinal fluid 0
CS
chemical synthesis 0
CH
chemistry 0
CL
classification 0
DF
deficiency 0
DE
drug effects 2
EC
economics 0
GE
genetics 2
HI
history 0
IM
immunology 2
IP
isolation & purification 0
ME
metabolism 12
PK
pharmacokinetics 0
PD
pharmacology 0
PH
physiology 0
PO
poisoning 0
RE
radiation effects 0
ST
standards 0
SD
supply & distribution 0
TU
therapeutic use 0
TO
toxicity 0
UL
ultrastructure 0
UR
urine 0

D Chemicals and Drugs
D12 Amino Acids, Peptides, and Proteins 16
D12.644 Peptides 1 380
D12.644.360 Intracellular Signaling Peptides and Proteins 174
D12.644.360.024 Adaptor Proteins, Signal Transducing 176
D12.644.360.024.050 14-3-3 Proteins 75
D12.644.360.024.065 A Kinase Anchor Proteins 1
D12.644.360.024.082 Angiomotins 1
D12.644.360.024.098 Arrestins 6
D12.644.360.024.131 CARD Signaling Adaptor Proteins 7
D12.644.360.024.264 Caveolin 1 14
D12.644.360.024.272 Caveolin 2 1
D12.644.360.024.280 Cortactin 1
D12.644.360.024.282 Crk-Associated Substrate Protein 7
D12.644.360.024.285 Death Domain Receptor Signaling Adaptor Proteins 5
D12.644.360.024.287 Discs Large Homolog 1 Protein
D12.644.360.024.288 Dishevelled Proteins 18
D12.644.360.024.290 GRB2 Adaptor Protein 3
D12.644.360.024.299 GRB7 Adaptor Protein
D12.644.360.024.300 GRB10 Adaptor Protein
D12.644.360.024.301 Insulin Receptor Substrate Proteins 6
D12.644.360.024.302 Interferon Regulatory Factors 11
D12.644.360.024.303 Interferon-Stimulated Gene Factor 3
D12.644.360.024.306 Kelch-Like ECH-Associated Protein 1 9
D12.644.360.024.309 Mediator Complex 5
D12.644.360.024.310 mTOR Associated Protein, LST8 Homolog
D12.644.360.024.311 Myeloid Differentiation Factor 88 16
D12.644.360.024.313 Nod Signaling Adaptor Proteins 1
D12.644.360.024.314 Nuclear Receptor Coactivators 6
D12.644.360.024.315 Nuclear Receptor Interacting Protein 1 3
D12.644.360.024.316 Paxillin 5
D12.644.360.024.318 PII Nitrogen Regulatory Proteins
D12.644.360.024.319 Protein Inhibitors of Activated STAT 3
D12.644.360.024.320 Proto-Oncogene Proteins c-crk 1
D12.644.360.024.321 Proto-Oncogene Proteins c-vav 4
D12.644.360.024.322 Rabphilin-3A
D12.644.360.024.323 Rapamycin-Insensitive Companion of mTOR Protein 2
D12.644.360.024.324 Regulatory-Associated Protein of mTOR
D12.644.360.024.328 Retinoblastoma Binding Proteins 3
D12.644.360.024.329 Sequestosome-1 Protein 3
D12.644.360.024.330 Shc Signaling Adaptor Proteins
D12.644.360.024.332 Signaling Lymphocytic Activation Molecule Associated Protein
D12.644.360.024.334 Smad Proteins 14
D12.644.360.024.342 STAT Transcription Factors 23
D12.644.360.024.342.100 STAT1 Transcription Factor 24
D12.644.360.024.342.200 STAT2 Transcription Factor 1
D12.644.360.024.342.300 STAT3 Transcription Factor 79
D12.644.360.024.342.400 STAT4 Transcription Factor 2
D12.644.360.024.342.500 STAT5 Transcription Factor 17
D12.644.360.024.342.600 STAT6 Transcription Factor 13
D12.644.360.024.374 Suppressor of Cytokine Signaling Proteins 11
D12.644.360.024.437 Syntenins 2
D12.644.360.024.469 Transcriptional Coactivator with PDZ-Binding Motif Proteins 1
D12.644.360.024.500 Tumor Necrosis Factor Receptor-Associated Peptides and Proteins 4
D12.644.360.024.750 YAP-Signaling Proteins 5
D12.776 Proteins 2 575
D12.776.157 Carrier Proteins 546
D12.776.157.057 Adaptor Proteins, Signal Transducing 176
D12.776.157.057.001 5-Lipoxygenase-Activating Proteins 1
D12.776.157.057.002 14-3-3 Proteins 75
D12.776.157.057.003 A Kinase Anchor Proteins 1
D12.776.157.057.005 Arrestins 6
D12.776.157.057.006 CARD Signaling Adaptor Proteins 7
D12.776.157.057.010 Caveolin 1 14
D12.776.157.057.012 Caveolin 2 1
D12.776.157.057.014 Cortactin 1
D12.776.157.057.016 Crk-Associated Substrate Protein 7
D12.776.157.057.018 Death Domain Receptor Signaling Adaptor Proteins 5
D12.776.157.057.023 Discs Large Homolog 1 Protein
D12.776.157.057.028 Dishevelled Proteins 18
D12.776.157.057.039 GRB10 Adaptor Protein
D12.776.157.057.041 GRB2 Adaptor Protein 3
D12.776.157.057.043 GRB7 Adaptor Protein
D12.776.157.057.045 Insulin Receptor Substrate Proteins 6
D12.776.157.057.050 Interferon Regulatory Factors 11
D12.776.157.057.061 Interferon-Stimulated Gene Factor 3
D12.776.157.057.067 Kelch-Like ECH-Associated Protein 1 9
D12.776.157.057.072 Mediator Complex 5
D12.776.157.057.073 mTOR Associated Protein, LST8 Homolog
D12.776.157.057.074 Myeloid Differentiation Factor 88 16
D12.776.157.057.078 Nod Signaling Adaptor Proteins 1
D12.776.157.057.080 Nuclear Receptor Coactivators 6
D12.776.157.057.086 Nuclear Receptor Interacting Protein 1 3
D12.776.157.057.092 Paxillin 5
D12.776.157.057.110 PII Nitrogen Regulatory Proteins
D12.776.157.057.124 Protein Inhibitors of Activated STAT 3
D12.776.157.057.139 Proto-Oncogene Proteins c-crk 1
D12.776.157.057.144 Proto-Oncogene Proteins c-vav 4
D12.776.157.057.150 Rabphilin-3A
D12.776.157.057.155 Rapamycin-Insensitive Companion of mTOR Protein 2
D12.776.157.057.157 Regulatory-Associated Protein of mTOR
D12.776.157.057.158 Retinoblastoma Binding Proteins 3
D12.776.157.057.160 Sequestosome-1 Protein 3
D12.776.157.057.162 Shc Signaling Adaptor Proteins
D12.776.157.057.166 Signaling Lymphocytic Activation Molecule Associated Protein
D12.776.157.057.170 Smad Proteins 14
D12.776.157.057.186 STAT Transcription Factors 23
D12.776.157.057.186.100 STAT1 Transcription Factor 24
D12.776.157.057.186.200 STAT2 Transcription Factor 1
D12.776.157.057.186.300 STAT3 Transcription Factor 79
D12.776.157.057.186.400 STAT4 Transcription Factor 2
D12.776.157.057.186.500 STAT5 Transcription Factor 17
D12.776.157.057.186.600 STAT6 Transcription Factor 13
D12.776.157.057.249 Suppressor of Cytokine Signaling Proteins 11
D12.776.157.057.374 Syntenins 2
D12.776.157.057.437 Transcriptional Coactivator with PDZ-Binding Motif Proteins 1
D12.776.157.057.500 Tumor Necrosis Factor Receptor-Associated Peptides and Proteins 4
D12.776.157.057.750 YAP-Signaling Proteins 5
D12.776.476 Intracellular Signaling Peptides and Proteins 174
D12.776.476.024 Adaptor Proteins, Signal Transducing 176
D12.776.476.024.034 5-Lipoxygenase-Activating Proteins 1
D12.776.476.024.050 14-3-3 Proteins 75
D12.776.476.024.069 A Kinase Anchor Proteins 1
D12.776.476.024.087 Angiomotins 1
D12.776.476.024.104 Arrestins 6
D12.776.476.024.139 CARD Signaling Adaptor Proteins 7
D12.776.476.024.280 Caveolin 1 14
D12.776.476.024.295 Caveolin 2 1
D12.776.476.024.311 Cortactin 1
D12.776.476.024.316 Crk-Associated Substrate Protein 7
D12.776.476.024.320 Death Domain Receptor Signaling Adaptor Proteins 5
D12.776.476.024.325 Discs Large Homolog 1 Protein
D12.776.476.024.330 Dishevelled Proteins 18
D12.776.476.024.377 GRB2 Adaptor Protein 3
D12.776.476.024.379 GRB7 Adaptor Protein
D12.776.476.024.380 GRB10 Adaptor Protein
D12.776.476.024.381 Homer Scaffolding Proteins 1
D12.776.476.024.382 Insulin Receptor Substrate Proteins 6
D12.776.476.024.385 Interferon Regulatory Factors 11
D12.776.476.024.386 Interferon-Stimulated Gene Factor 3
D12.776.476.024.387 Kelch-Like ECH-Associated Protein 1 9
D12.776.476.024.388 Mediator Complex 5
D12.776.476.024.389 mTOR Associated Protein, LST8 Homolog
D12.776.476.024.390 Myeloid Differentiation Factor 88 16
D12.776.476.024.391 Nod Signaling Adaptor Proteins 1
D12.776.476.024.394 Nuclear Receptor Coactivators 6
D12.776.476.024.396 Nuclear Receptor Interacting Protein 1 3
D12.776.476.024.397 Paxillin 5
D12.776.476.024.400 PII Nitrogen Regulatory Proteins
D12.776.476.024.402 Protein Inhibitors of Activated STAT 3
D12.776.476.024.404 Proto-Oncogene Proteins c-crk 1
D12.776.476.024.407 Proto-Oncogene Proteins c-vav 4
D12.776.476.024.409 Rabphilin-3A
D12.776.476.024.411 Rapamycin-Insensitive Companion of mTOR Protein 2
D12.776.476.024.414 Receptor Activity-Modifying Proteins 1
D12.776.476.024.419 Regulatory-Associated Protein of mTOR
D12.776.476.024.420 Retinoblastoma Binding Proteins 3
D12.776.476.024.422 Sequestosome-1 Protein 3
D12.776.476.024.424 Shc Signaling Adaptor Proteins
D12.776.476.024.426 Signaling Lymphocytic Activation Molecule Associated Protein
D12.776.476.024.428 Smad Proteins 14
D12.776.476.024.430 STAT Transcription Factors 23
D12.776.476.024.430.100 STAT1 Transcription Factor 24
D12.776.476.024.430.200 STAT2 Transcription Factor 1
D12.776.476.024.430.300 STAT3 Transcription Factor 79
D12.776.476.024.430.400 STAT4 Transcription Factor 2
D12.776.476.024.430.500 STAT5 Transcription Factor 17
D12.776.476.024.430.600 STAT6 Transcription Factor 13
D12.776.476.024.437 Suppressor of Cytokine Signaling Proteins 11
D12.776.476.024.468 Syntenins 2
D12.776.476.024.484 Transcriptional Coactivator with PDZ-Binding Motif Proteins 1
D12.776.476.024.500 Tumor Necrosis Factor Receptor-Associated Peptides and Proteins 4
D12.776.476.024.750 YAP-Signaling Proteins 5
D12.776.930 Transcription Factors 727
D12.776.930.100 Adenovirus E1A Proteins 5
D12.776.930.110 Adenovirus E1B Proteins 3
D12.776.930.120 Antennapedia Homeodomain Protein 1
D12.776.930.123 AIRE Protein 2
D12.776.930.125 Basic Helix-Loop-Helix Transcription Factors 61
D12.776.930.127 Basic-Leucine Zipper Transcription Factors 18
D12.776.930.130 beta Catenin 97
D12.776.930.137 BRCA1 Protein 101
D12.776.930.146 CDX2 Transcription Factor 3
D12.776.930.155 Core Binding Factors 3
D12.776.930.160 COUP Transcription Factors
D12.776.930.165 Cyclic AMP Receptor Protein 2
D12.776.930.211 E2F Transcription Factors 16
D12.776.930.213 Early Growth Response Transcription Factors 1
D12.776.930.215 Elongin
D12.776.930.216 Erythroid-Specific DNA-Binding Factors 1
D12.776.930.312 Fushi Tarazu Transcription Factors
D12.776.930.313 G-Box Binding Factors
D12.776.930.314 GATA Transcription Factors 2
D12.776.930.315 Goosecoid Protein 2
D12.776.930.317 Heat Shock Transcription Factors 1
D12.776.930.318 Hepatocyte Nuclear Factors 5
D12.776.930.320 Homeobox Protein PITX2
D12.776.930.321 Homeobox Protein Nkx-2.2
D12.776.930.324 Homeobox Protein Nkx-2.5 1
D12.776.930.325 Host Cell Factor C1 2
D12.776.930.326 I-kappa B Proteins 5
D12.776.930.327 Immunoglobulin J Recombination Signal Sequence-Binding Protein
D12.776.930.329 Inhibitor of Differentiation Proteins 2
D12.776.930.332 Interferon Regulatory Factors 11
D12.776.930.354 Interferon-Stimulated Gene Factor 3
D12.776.930.375 Kruppel-Like Transcription Factors 26
D12.776.930.386 Leucine-Responsive Regulatory Protein
D12.776.930.397 MADS Domain Proteins 3
D12.776.930.419 MDS1 and EVI1 Complex Locus Protein 2
D12.776.930.440 MSX1 Transcription Factor 8
D12.776.930.462 Myeloid Ecotropic Viral Integration Site 1 Protein 1
D12.776.930.483 Myeloid-Lymphoid Leukemia Protein 39
D12.776.930.542 Nanog Homeobox Protein 3
D12.776.930.600 NF-kappa B 215
D12.776.930.608 NFATC Transcription Factors 13
D12.776.930.612 NFI Transcription Factors 6
D12.776.930.616 Nuclear Factor 90 Proteins
D12.776.930.617 Nuclear Receptor Coactivators 6
D12.776.930.618 Nuclear Respiratory Factors
D12.776.930.640 Onecut Transcription Factors
D12.776.930.645 Orphan Nuclear Receptors 2
D12.776.930.650 Otx Transcription Factors 4
D12.776.930.680 p300-CBP Transcription Factors 5
D12.776.930.700 Paired Box Transcription Factors 21
D12.776.930.705 Peroxisome Proliferator-Activated Receptors 54
D12.776.930.710 POU Domain Factors 4
D12.776.930.712 Pre-B-Cell Leukemia Transcription Factor 1 2
D12.776.930.713 Promyelocytic Leukemia Protein 4
D12.776.930.714 B-Cell Lymphoma 3 Protein
D12.776.930.715 Proto-Oncogene Proteins c-bcl-6 3
D12.776.930.720 Proto-Oncogene Proteins c-ets 19
D12.776.930.725 Proto-Oncogene Proteins c-myb 30
D12.776.930.730 Proto-Oncogene Proteins c-rel 2
D12.776.930.760 Receptors, Aryl Hydrocarbon 133
D12.776.930.770 Receptors, Notch 20
D12.776.930.775 Receptors, Retinoic Acid 42
D12.776.930.778 Receptors, Steroid 143
D12.776.930.780 Repressor Proteins 189
D12.776.930.785 Rho Factor 12
D12.776.930.800 Sigma Factor 55
D12.776.930.806 Smad Proteins 14
D12.776.930.809 SMARCB1 Protein 15
D12.776.930.815 Snail Family Transcription Factors 4
D12.776.930.823 SOX Transcription Factors 1
D12.776.930.840 STAT Transcription Factors 23
D12.776.930.840.100 STAT1 Transcription Factor 24
D12.776.930.840.200 STAT2 Transcription Factor 1
D12.776.930.840.300 STAT3 Transcription Factor 79
D12.776.930.840.400 STAT4 Transcription Factor 2
D12.776.930.840.500 STAT5 Transcription Factor 17
D12.776.930.840.600 STAT6 Transcription Factor 13
D12.776.930.850 T-Box Domain Proteins 14
D12.776.930.875 TCF Transcription Factors 3
D12.776.930.882 TEA Domain Transcription Factors 3
D12.776.930.888 Thyroid Nuclear Factor 1
D12.776.930.900 Trans-Activators 110
D12.776.930.907 Transcription Factor AP-2 1
D12.776.930.908 Transcription Factor DP1 10
D12.776.930.919 Transcription Factor MTF-1
D12.776.930.930 Transcription Factors, General 1
D12.776.930.955 Transcriptional Elongation Factors 8
D12.776.930.960 Tristetraprolin 2
D12.776.930.969 Tumor Protein p73 6
D12.776.930.977 Winged-Helix Transcription Factors

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