Separase [separasa]

topical
1
Terms

separáza

Persistent link   https://www.medvik.cz/link/D064247
Definition

Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.

DUI
D064247 MeSH Browser
CUI
M0580540
Previous indexing
Cell Cycle Proteins (1999-2013); Endopeptidases (1999-2013)
History note
2014
Public note
2014; was indexed under ENDOPEPTIDASES and CELL CYCLE PROTEINS 1999-2013

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics 1
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 1
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 551
D08.811.277 Hydrolases 475
D08.811.277.656 Peptide Hydrolases 560
D08.811.277.656.262 Cysteine Proteases 12
D08.811.277.656.262.500 Cysteine Endopeptidases 44
D08.811.277.656.262.500.096 Bromelains 37
D08.811.277.656.262.500.108 3C Viral Proteases 1
D08.811.277.656.262.500.120 Calpain 23
D08.811.277.656.262.500.126 Caspases 158
D08.811.277.656.262.500.133 Cathepsin B 46
D08.811.277.656.262.500.146 Cathepsin F
D08.811.277.656.262.500.153 Cathepsin H 1
D08.811.277.656.262.500.156 Cathepsin K 13
D08.811.277.656.262.500.157 Cathepsin L 11
D08.811.277.656.262.500.158 Cathepsin W
D08.811.277.656.262.500.160 Chymopapain
D08.811.277.656.262.500.350 Ficain
D08.811.277.656.262.500.468 Gingipain Cysteine Endopeptidases
D08.811.277.656.262.500.585 Papain 39
D08.811.277.656.262.500.792 Separase 1
D08.811.277.656.262.500.896 Viral Papain-like Proteases
D08.811.277.656.300 Endopeptidases 211
D08.811.277.656.300.200 Cysteine Endopeptidases 44
D08.811.277.656.300.200.096 Bromelains 37
D08.811.277.656.300.200.120 Calpain 23
D08.811.277.656.300.200.126 Caspases 158
D08.811.277.656.300.200.133 Cathepsin B 46
D08.811.277.656.300.200.146 Cathepsin F
D08.811.277.656.300.200.153 Cathepsin H 1
D08.811.277.656.300.200.156 Cathepsin K 13
D08.811.277.656.300.200.157 Cathepsin L 11
D08.811.277.656.300.200.158 Cathepsin W
D08.811.277.656.300.200.160 Chymopapain
D08.811.277.656.300.200.350 Ficain
D08.811.277.656.300.200.585 Papain 39
D08.811.277.656.300.200.792 Separase 1
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 581
D12.776.167 Cell Cycle Proteins 330
D12.776.167.024 Anaphase-Promoting Complex-Cyclosome 12
D12.776.167.049 Aurora Kinases 4
D12.776.167.100 cdc25 Phosphatases 28
D12.776.167.150 Cellular Apoptosis Susceptibility Protein 4
D12.776.167.163 Cohesins
D12.776.167.175 Cullin Proteins 7
D12.776.167.187 Cyclin-Dependent Kinase Inhibitor Proteins 44
D12.776.167.200 Cyclin-Dependent Kinases 231
D12.776.167.218 Cyclins 112
D12.776.167.242 F-Box-WD Repeat-Containing Protein 7 3
D12.776.167.254 GADD45 Proteins
D12.776.167.265 Geminin 1
D12.776.167.313 Mad2 Proteins 1
D12.776.167.409 Minichromosome Maintenance Proteins 4
D12.776.167.457 NIMA-Related Kinases 4
D12.776.167.469 Polo-like Kinases
D12.776.167.481 S100 Calcium Binding Protein A6 2
D12.776.167.504 Securin 1
D12.776.167.552 Separase 1
D12.776.167.564 Structural Maintenance of Chromosome Protein 1
D12.776.167.576 Survivin 6
D12.776.167.600 Tumor Suppressor Protein p14ARF 4
D12.776.167.800 Valosin Containing Protein 3

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