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Autor
Kroemer, Guido 2 Abdelkader, Nejma 1 Aranda, Fernando 1 Bloy, Norma 1 Bossut, Noelie 1 Buqué, Aitziber 1 Castoldi, Francesca 1 Chen, Guo 1 Codogno, Patrice 1 Cremer, Isabelle 1 Dupont, Nicolas 1 Durand, Sylvere 1 Eggermont, Alexander 1 Enot, David P 1 Fridman, Wolf Hervé 1 Fucikova, Jitka 1 Galluzzi, Lorenzo 1 Galon, Jérôme 1 Kroemer, Romano 1 Lachkar, Sylvie 1
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Pracoviště
Equipe 11 labellisée par la Ligue Nat... 2 Gustave Roussy Cancer Campus Villejui... 2 INSERM U1138 Paris France 2 Metabolomics and Cell Biology Platfor... 2 Pôle de Biologie Hôpital Européen Geo... 2 Université Paris Descartes Paris 5 So... 2 BioTechMed Graz Humboldtstraße 50 801... 1 CNRS UMR8253 Paris France 1 Departamento de Biología Fundamental ... 1 Department of Basic Sciences Faculty ... 1 Department of Biochemistry Sargodha M... 1 Department of Cell Biology and Molecu... 1 Department of Women's and Children's ... 1 Dept of Immunology 2nd Faculty of Med... 1 Equipe 13 Centre de Recherche des Cor... 1 Group of Immune receptors of the Inna... 1 INSERM U1015 CICBT507 Villejuif France 1 INSERM U1151 Paris France 1 INSERM U970 Paris France 1 Institut Necker Enfants Malades Paris... 1
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Autor
Kroemer, Guido 2 Abdelkader, Nejma 1 Aranda, Fernando 1 Bloy, Norma 1 Bossut, Noelie 1 Buqué, Aitziber 1 Castoldi, Francesca 1 Chen, Guo 1 Codogno, Patrice 1 Cremer, Isabelle 1 Dupont, Nicolas 1 Durand, Sylvere 1 Eggermont, Alexander 1 Enot, David P 1 Fridman, Wolf Hervé 1 Fucikova, Jitka 1 Galluzzi, Lorenzo 1 Galon, Jérôme 1 Kroemer, Romano 1 Lachkar, Sylvie 1
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Pracoviště
Equipe 11 labellisée par la Ligue Nat... 2 Gustave Roussy Cancer Campus Villejui... 2 INSERM U1138 Paris France 2 Metabolomics and Cell Biology Platfor... 2 Pôle de Biologie Hôpital Européen Geo... 2 Université Paris Descartes Paris 5 So... 2 BioTechMed Graz Humboldtstraße 50 801... 1 CNRS UMR8253 Paris France 1 Departamento de Biología Fundamental ... 1 Department of Basic Sciences Faculty ... 1 Department of Biochemistry Sargodha M... 1 Department of Cell Biology and Molecu... 1 Department of Women's and Children's ... 1 Dept of Immunology 2nd Faculty of Med... 1 Equipe 13 Centre de Recherche des Cor... 1 Group of Immune receptors of the Inna... 1 INSERM U1015 CICBT507 Villejuif France 1 INSERM U1151 Paris France 1 INSERM U970 Paris France 1 Institut Necker Enfants Malades Paris... 1
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Pietrocola, Federico
Autor Pietrocola, Federico Gustave Roussy Cancer Campus, Villejuif, France INSERM, U1138, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France Université Pierre et Marie Curie, Paris, France
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Castoldi, Francesca
Autor Castoldi, Francesca Gustave Roussy Cancer Campus, Villejuif, France INSERM, U1138, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France Université Pierre et Marie Curie, Paris, France Université Paris-Sud/Paris XI, Faculté de Médecine, Kremlin-Bicêtre, France, Paris, France Sotio a.c., Prague, Czech Republic
- Markaki, Maria
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Lachkar, Sylvie
Autor Lachkar, Sylvie Gustave Roussy Cancer Campus, Villejuif, France INSERM, U1138, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France Université Pierre et Marie Curie, Paris, France
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Chen, Guo
Autor Chen, Guo Gustave Roussy Cancer Campus, Villejuif, France INSERM, U1138, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France Université Pierre et Marie Curie, Paris, France
- Enot, David P
- Durand, Sylvere
- Bossut, Noelie
- Tong, Mingming
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Malik, Shoaib A
Autor Malik, Shoaib A Gustave Roussy Cancer Campus, Villejuif, France INSERM, U1138, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France Université Pierre et Marie Curie, Paris, France Department of Biochemistry, Sargodha Medical College, Sargodha, Pakistan
NLK
Cell Press Free Archives
od 2012
Directory of Open Access Journals
od 2012
Free Medical Journals
od 2012
Freely Accessible Science Journals
od 2012-01-26
Open Access Digital Library
od 2012-01-26
Open Access Digital Library
od 2012-01-01
Elsevier Open Access Journals
od 2012-01-26
PubMed
29490275
DOI
10.1016/j.celrep.2018.02.024
Knihovny.cz E-zdroje
The age-associated deterioration in cellular and organismal functions associates with dysregulation of nutrient-sensing pathways and disabled autophagy. The reactivation of autophagic flux may prevent or ameliorate age-related metabolic dysfunctions. Non-toxic compounds endowed with the capacity to reduce the overall levels of protein acetylation and to induce autophagy have been categorized as caloric restriction mimetics (CRMs). Here, we show that aspirin or its active metabolite salicylate induce autophagy by virtue of their capacity to inhibit the acetyltransferase activity of EP300. While salicylate readily stimulates autophagic flux in control cells, it fails to further increase autophagy levels in EP300-deficient cells, as well as in cells in which endogenous EP300 has been replaced by salicylate-resistant EP300 mutants. Accordingly, the pro-autophagic activity of aspirin and salicylate on the nematode Caenorhabditis elegans is lost when the expression of the EP300 ortholog cpb-1 is reduced. Altogether, these findings identify aspirin as an evolutionary conserved CRM.
- MeSH
- acetylkoenzym A metabolismus MeSH
- Aspirin farmakologie MeSH
- autofagie účinky léků genetika MeSH
- kalorická restrikce * MeSH
- lidé MeSH
- metabolom účinky léků MeSH
- metabolomika MeSH
- myši inbrední C57BL MeSH
- nádorové buněčné linie MeSH
- protein p300 asociovaný s E1A metabolismus MeSH
- zvířata MeSH
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- lidé MeSH
- zvířata MeSH
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- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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Buqué, Aitziber
Autor Buqué, Aitziber INSERM, U1138, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Université Pierre et Marie Curie/Paris VI, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Gustave Roussy Cancer Campus, Villejuif, France
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Bloy, Norma
Autor Bloy, Norma INSERM, U1138, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Université Pierre et Marie Curie/Paris VI, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Gustave Roussy Cancer Campus, Villejuif, France
- Aranda, Fernando
- Cremer, Isabelle
- Eggermont, Alexander
- Fridman, Wolf Hervé
- Fucikova, Jitka
- Galon, Jérôme
- Spisek, Radek
- Tartour, Eric
NLK
PubMed Central
od 2012
Europe PubMed Central
od 2012 do Před 1 rokem
ROAD: Directory of Open Access Scholarly Resources
od 2012
PubMed
27471617
DOI
10.1080/2162402x.2016.1149674
Knihovny.cz E-zdroje
Progressing malignancies establish robust immunosuppressive networks that operate both systemically and locally. In particular, as tumors escape immunosurveillance, they recruit increasing amounts of myeloid and lymphoid cells that exert pronounced immunosuppressive effects. These cells not only prevent the natural recognition of growing neoplasms by the immune system, but also inhibit anticancer immune responses elicited by chemo-, radio- and immuno therapeutic interventions. Throughout the past decade, multiple strategies have been devised to counteract the accumulation or activation of tumor-infiltrating immunosuppressive cells for therapeutic purposes. Here, we review recent preclinical and clinical advances on the use of small molecules that target the immunological tumor microenvironment for cancer therapy. These agents include inhibitors of indoleamine 2,3-dioxigenase 1 (IDO1), prostaglandin E2, and specific cytokine receptors, as well as modulators of intratumoral purinergic signaling and arginine metabolism.
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
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