A new tacrine based cholinesterase inhibitor, N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine (1), was designed and synthesized to interact with specific regions of human acetylcholinesterase and human butyrylcholinesterase. Its inhibitory ability towards cholinesterases was determined and compared to tacrine (THA) and 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA). The assessment of IC50 values revealed 1 as a weak inhibitor of both tested enzymes.

• MeSH
• Acridines chemical synthesis   chemistry   pharmacology   MeSH
• Alzheimer Disease drug therapy   enzymology   MeSH
• Butyrylcholinesterase chemistry   pharmacology   MeSH
• Cholinesterase Inhibitors chemical synthesis   chemistry   pharmacology   MeSH
• Cholinesterases chemistry   MeSH
• Heterocyclic Compounds, 3-Ring chemical synthesis   chemistry   pharmacology   MeSH
• Humans MeSH
• Drug Evaluation, Preclinical MeSH
• Tacrine chemistry   pharmacology   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Comparative Study MeSH