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Autor
Arora, Natasha 1 Chen, Marcus 1 Denham, Ian 1 Dupin, Nicolas 1 Forsyth, R Allyn 1 Giacani, Lorenzo 1 Grange, Philippe A 1 Grillová, Linda 1 Mechaly, Ariel E 1 Mikalová, Lenka 1 Niesnerová, Anežka 1 Noda, Angel A 1 Nováková, Markéta 1 Oppelt, Jan 1 Picardeau, Mathieu 1 Pospíšilová, Petra 1 Strnadel, Radim 1 Weston, Christopher 1 Čejková, Darina 1 Šmajs, David 1
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Pracoviště
Biology of Spirochetes Unit Institut ... 1 CEITEC Central European Institute of ... 1 Department of Biology Faculty of Medi... 1 Department of Biology Faculty of Medi... 1 Department of Dermatovenerology Unive... 1 Department of Immunology Veterinary R... 1 Department of Medicine Division of Al... 1 Department of Mycology Bacteriology I... 1 Faculté de Médecine Laboratoire de De... 1 Faculté de Médecine Laboratoire de De... 1 GeneticPrime Dx Inc La Jolla CA Unite... 1 GeneticPrime Dx Inc La Jolla CA Unite... 1 Melbourne Sexual Health Centre Alfred... 1 Melbourne Sexual Health Centre Alfred... 1 Plateforme de Cristallographie Instit... 1 Zurich Institute of Forensic Medicine... 1
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Autor
Arora, Natasha 1 Chen, Marcus 1 Denham, Ian 1 Dupin, Nicolas 1 Forsyth, R Allyn 1 Giacani, Lorenzo 1 Grange, Philippe A 1 Grillová, Linda 1 Mechaly, Ariel E 1 Mikalová, Lenka 1 Niesnerová, Anežka 1 Noda, Angel A 1 Nováková, Markéta 1 Oppelt, Jan 1 Picardeau, Mathieu 1 Pospíšilová, Petra 1 Strnadel, Radim 1 Weston, Christopher 1 Čejková, Darina 1 Šmajs, David 1
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Pracoviště
Biology of Spirochetes Unit Institut ... 1 CEITEC Central European Institute of ... 1 Department of Biology Faculty of Medi... 1 Department of Biology Faculty of Medi... 1 Department of Dermatovenerology Unive... 1 Department of Immunology Veterinary R... 1 Department of Medicine Division of Al... 1 Department of Mycology Bacteriology I... 1 Faculté de Médecine Laboratoire de De... 1 Faculté de Médecine Laboratoire de De... 1 GeneticPrime Dx Inc La Jolla CA Unite... 1 GeneticPrime Dx Inc La Jolla CA Unite... 1 Melbourne Sexual Health Centre Alfred... 1 Melbourne Sexual Health Centre Alfred... 1 Plateforme de Cristallographie Instit... 1 Zurich Institute of Forensic Medicine... 1
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PubMed
31417509
DOI
10.3389/fmicb.2019.01691
Knihovny.cz E-zdroje
Syphilis, caused by Treponema pallidum subsp. pallidum (TPA), remains an important public health problem with an increasing worldwide prevalence. Despite recent advances in in vitro cultivation, genetic variability of this pathogen during infection is poorly understood. Here, we present contemporary and geographically diverse complete treponemal genome sequences isolated directly from patients using a methyl-directed enrichment prior to sequencing. This approach reveals that approximately 50% of the genetic diversity found in TPA is driven by inter- and/or intra-strain recombination events, particularly in strains belonging to one of the defined genetic groups of syphilis treponemes: Nichols-like strains. Recombinant loci were found to encode putative outer-membrane proteins and the recombination variability was almost exclusively found in regions predicted to be at the host-pathogen interface. Genetic recombination has been considered to be a rare event in treponemes, yet our study unexpectedly showed that it occurs at a significant level and may have important impacts in the biology of this pathogen, especially as these events occur primarily in the outer membrane proteins. This study reveals the existence of strains with different repertoires of surface-exposed antigens circulating in the current human population, which should be taken into account during syphilis vaccine development.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.