BACKGROUND: A 27-year-old man was referred to an oncology department following right orchiectomy for a stage I testicular seminoma at high risk for recurrence. He presented 6 weeks after the orchiectomy with an atrophic left testis, fatigue and a history of infertility. INVESTIGATIONS: Measurement of serum levels of urea, electrolytes, liver enzymes, bilirubin, human chorionic gonadotropin, alpha-fetoprotein, lactate dehydrogenase, testosterone and luteinizing hormone, full blood count, and left testicular biopsy. DIAGNOSIS: Tubular atrophy of the left testis with islands of intratubular germ cell neoplasia (ITGCN), and hypergonadotropic hypogonadism. MANAGEMENT: The patient received adjuvant chemotherapy as a single dose of carboplatin for the seminoma at high risk for recurrence, and testosterone replacement for the hypergonadotropic hypogonadism. Radiotherapy to the ITGCN-bearing solitary testis or a second orchiectomy was offered to prevent the progression of ITGCN into an invasive germ cell tumor. After exploring his options with regards to fertility treatment, the patient chose to undergo second orchiectomy with a subsequent, unsuccessful, attempt at sperm retrieval. At 20 months after diagnosis of his initial seminoma the patient showed no sign of recurrence.
- MeSH
- androgeny terapeutické užití MeSH
- antitumorózní látky terapeutické užití MeSH
- atrofie MeSH
- dospělí MeSH
- germinální a embryonální nádory patologie MeSH
- hypogonadismus diagnóza terapie MeSH
- karboplatina terapeutické užití MeSH
- lidé MeSH
- mnohočetné primární nádory patologie terapie MeSH
- orchiektomie MeSH
- semenotvorné kanálky patologie MeSH
- seminom chirurgie patologie MeSH
- testikulární nádory chirurgie patologie MeSH
- testis patologie chirurgie MeSH
- testosteron terapeutické užití MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
