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Autor
Albanes, Demetrius 1 Aleksandrova, Krasimira 1 Banbury, Barbara 1 Berndt, Sonja I 1 Brenner, Hermann 1 Buchanan, Daniel D 1 Bueno-de-Mesquita, Bas 1 Campbell, Peter T 1 Castellví-Bel, Sergi 1 Chan, Andrew T 1 Chang-Claude, Jenny 1 Dimou, Niki 1 Ellingjord-Dale, Merete 1 Figueiredo, Jane C 1 Gallinger, Steven J 1 Giles, Graham G 1 Giovannucci, Edward 1 Gruber, Stephen B 1 Gsur, Andrea 1 Gunter, Marc J 1
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Pracoviště
Behavioral and Epidemiology Research ... 1 Bristol Medical School Department of ... 1 CESP Fac de médecine Univ Paris Sud F... 1 CESP Fac de médecine Univ Paris Sud F... 1 CIBER de Epidemiología y Salud Públic... 1 CIBER de Epidemiología y Salud Públic... 1 CIBER de Epidemiología y Salud Públic... 1 Cancer Epidemiology Unit Nuffield Dep... 1 Cancer Risk Factors and Life Style Ep... 1 Center for Gastrointestinal Biology a... 1 Centre for Epidemiology and Biostatis... 1 Centre for Epidemiology and Biostatis... 1 Centre for Epidemiology and Biostatis... 1 Centre for Epidemiology and Biostatis... 1 Centre for Epidemiology and Biostatis... 1 Centre for Epidemiology and Biostatis... 1 Clinical Genetics Service Department ... 1 Department of Clinical Genetics Karol... 1 Department of Community Medicine and ... 1 Department of Epidemiology Harvard T ... 1
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Autor
Albanes, Demetrius 1 Aleksandrova, Krasimira 1 Banbury, Barbara 1 Berndt, Sonja I 1 Brenner, Hermann 1 Buchanan, Daniel D 1 Bueno-de-Mesquita, Bas 1 Campbell, Peter T 1 Castellví-Bel, Sergi 1 Chan, Andrew T 1 Chang-Claude, Jenny 1 Dimou, Niki 1 Ellingjord-Dale, Merete 1 Figueiredo, Jane C 1 Gallinger, Steven J 1 Giles, Graham G 1 Giovannucci, Edward 1 Gruber, Stephen B 1 Gsur, Andrea 1 Gunter, Marc J 1
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Pracoviště
Behavioral and Epidemiology Research ... 1 Bristol Medical School Department of ... 1 CESP Fac de médecine Univ Paris Sud F... 1 CESP Fac de médecine Univ Paris Sud F... 1 CIBER de Epidemiología y Salud Públic... 1 CIBER de Epidemiología y Salud Públic... 1 CIBER de Epidemiología y Salud Públic... 1 Cancer Epidemiology Unit Nuffield Dep... 1 Cancer Risk Factors and Life Style Ep... 1 Center for Gastrointestinal Biology a... 1 Centre for Epidemiology and Biostatis... 1 Centre for Epidemiology and Biostatis... 1 Centre for Epidemiology and Biostatis... 1 Centre for Epidemiology and Biostatis... 1 Centre for Epidemiology and Biostatis... 1 Centre for Epidemiology and Biostatis... 1 Clinical Genetics Service Department ... 1 Department of Clinical Genetics Karol... 1 Department of Community Medicine and ... 1 Department of Epidemiology Harvard T ... 1
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- Papadimitriou, Nikos
- Dimou, Niki
- Tsilidis, Konstantinos K
- Banbury, Barbara
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Martin, Richard M
Autor Martin, Richard M MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Bristol Medical School, Department of Population Health Sciences, University of Bristol, Bristol, UK. National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK
- Lewis, Sarah J
- Kazmi, Nabila
- Robinson, Timothy M
- Albanes, Demetrius
- Aleksandrova, Krasimira
Free Medical Journals od 2010
Nature Open Access od 2010-12-01
PubMed Central od 2012
Europe PubMed Central od 2012
ProQuest Central od 2010-01-01
Open Access Digital Library od 2015-01-01
Open Access Digital Library od 2015-01-01
Medline Complete (EBSCOhost) od 2012-11-01
Health & Medicine (ProQuest) od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources od 2010
PubMed
32001714
DOI
10.1038/s41467-020-14389-8
Knihovny.cz E-zdroje
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.
- MeSH
- akcelerometrie MeSH
- cvičení * MeSH
- genetická predispozice k nemoci * MeSH
- jednonukleotidový polymorfismus genetika MeSH
- kolorektální nádory genetika MeSH
- lidé MeSH
- mendelovská randomizace * MeSH
- nádory prsu genetika MeSH
- odds ratio MeSH
- rizikové faktory MeSH
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- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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