The aim of our study was to develop a model producing obese mice in early adulthood (4-6 weeks) based on their over-nutrition during fetal and early postnatal development. The fertilized dams of the parental generation were fed the standard diet supplemented with high-energy nutritional product Ensure Plus during gestation and lactation. Delivered weanlings were then fed with standard or supplemented diet and assessed for body fat deposits using EchoMRI at the time of early and late adulthood. Maternal over-feeding during the period before weaning had the most significant effect on obesity development in the filial generation. In weanlings, significantly higher body fat deposits and average body weight were recorded. Later, further significant increase in percentage of body fat in both male and female mice was observed. Withdrawal of the Ensure Plus supplement caused a decrease in the percentage of body fat in part of the filial generation. In offspring fed the standard diet, higher fat deposits persisted till the time of late adulthood. We conclude that this diet-induced obesity model might be used in exploration of the effects of elevated body fat on physiological functions of various organ systems during juvenile and early adulthood periods of life of a human being.

• MeSH
• koně MeSH
• lidé MeSH
• modely nemocí na zvířatech * MeSH
• myši inbrední ICR MeSH
• myši MeSH
• nadměrná výživa komplikace   metabolismus   MeSH
• náhodné rozdělení MeSH
• obezita chemicky indukované   etiologie   metabolismus   MeSH
• skupinový efekt MeSH
• těhotenství MeSH
• tuková tkáň metabolismus   MeSH
• věkové faktory MeSH
• vitamin K aplikace a dávkování   škodlivé účinky   MeSH
• zpožděný efekt prenatální expozice chemicky indukované   etiologie   metabolismus   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• myši MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH