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Autor
Argalacsova, Sona 1 Bielcikova, Zuzana 1 Borecka, Marianna 1 Brychta, Milan 1 Chodacka, Martina 1 Cmejlova, Vlastimila 1 Janatova, Marketa 1 Kleibl, Zdenek 1 Kleiblova, Petra 1 Konopasek, Bohuslav 1 Kotlas, Jaroslav 1 Kozevnikovova, Renata 1 Krizova, Ludmila 1 Lhotova, Klara 1 Mateju, Martin 1 Miskarova, Lenka 1 Novotny, Jan 1 Petruzelka, Lubos 1 Smejkalova-Musilova, Denisa 1 Sochor, Marek 1
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Department of Oncology 1st Faculty of... 1 Department of Oncology 1st Faculty of... 1 Department of Oncology 2nd Faculty of... 1 Department of Oncology Chomutov Hospi... 1 Department of Oncology Masaryk Hospit... 1 Department of Oncology Medicon Roskot... 1 Department of Oncology Vzdusna 1360 6... 1 Department of Radiotherapy and Oncolo... 1 Department of Surgery Sunderby Hospit... 1 Institute of Biochemistry and Experim... 1 Institute of Biology and Medical Gene... 1 Institute of Biology and Medical Gene... 1 Institute of Radiation Oncology 1st F... 1
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Autor
Argalacsova, Sona 1 Bielcikova, Zuzana 1 Borecka, Marianna 1 Brychta, Milan 1 Chodacka, Martina 1 Cmejlova, Vlastimila 1 Janatova, Marketa 1 Kleibl, Zdenek 1 Kleiblova, Petra 1 Konopasek, Bohuslav 1 Kotlas, Jaroslav 1 Kozevnikovova, Renata 1 Krizova, Ludmila 1 Lhotova, Klara 1 Mateju, Martin 1 Miskarova, Lenka 1 Novotny, Jan 1 Petruzelka, Lubos 1 Smejkalova-Musilova, Denisa 1 Sochor, Marek 1
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Pracoviště
Department of Oncology 1st Faculty of... 1 Department of Oncology 1st Faculty of... 1 Department of Oncology 2nd Faculty of... 1 Department of Oncology Chomutov Hospi... 1 Department of Oncology Masaryk Hospit... 1 Department of Oncology Medicon Roskot... 1 Department of Oncology Vzdusna 1360 6... 1 Department of Radiotherapy and Oncolo... 1 Department of Surgery Sunderby Hospit... 1 Institute of Biochemistry and Experim... 1 Institute of Biology and Medical Gene... 1 Institute of Biology and Medical Gene... 1 Institute of Radiation Oncology 1st F... 1
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Zdroj
Free Medical Journals od 2009
PubMed Central od 2009
Europe PubMed Central od 2009
ProQuest Central od 2009-01-01
Open Access Digital Library od 2009-01-01
Open Access Digital Library od 2009-01-01
ROAD: Directory of Open Access Scholarly Resources od 2009
PubMed
31141992
DOI
10.3390/cancers11060738
Knihovny.cz E-zdroje
Breast cancer (BC) prognosis in BRCA1 and BRCA2 mutation carriers has been reported contradictorily, and the significance of variables influencing prognosis in sporadic BC is not established in BC patients with hereditary BRCA1/BRCA2 mutations. In this retrospective cohort study, we analyzed the effect of clinicopathological characteristics on BC prognosis (disease-free survival [DFS] and disease-specific survival [DSS]) in hereditary BRCA1/BRCA2 mutation carriers. We enrolled 234 BRCA1/BRCA2 mutation carriers and 899 non-carriers, of whom 191 carriers and 680 non-carriers, with complete data, were available for survival analyses. We found that patients with ER-positive tumors developed disease recurrence 2.3-times more likely when they carried a BRCA1/BRCA2 mutation (23/60; 38.3% ER-positive carriers vs. 74/445; 16.6% ER-positive non-carriers; p < 0.001). ER-positive mutation carriers also had a 3.4-times higher risk of death due to BC compared with ER-positive non-carriers (13/60; 21.7% vs. 28/445; 6.3%; p < 0.001). Moreover, prognosis in ER-negative BRCA1/BRCA2 mutation carriers was comparable with that in ER-positive non-carriers. Our study demonstrates that ER-positivity worsens BC prognosis in BRCA1/BRCA2 mutation carriers, while prognosis for carriers with ER-negative tumors (including early-onset) is significantly better and comparable with that in ER-positive, older BC non-carriers. These observations indicate that BRCA1/BRCA2 mutation carriers with ER-positive BC represent high-risk patients.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.