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Autor
Al-Rasadi, Khalid 1 Barter, Philip J 1 Baum, Seth J 1 Catapano, Alberico L 1 Chapman, M John 1 Cuchel, Marina A 1 Defesche, Joep C 1 Folco, Emanuela 1 Freiberger, Tomas 1 Genest, Jacques 1 Gidding, Samuel S 1 Harada-Shiba, Mariko 1 Hegele, Robert A 1 Hovingh, G Kees 1 Humphries, Steve E 1 Jackson, Ann S 1 Mata, Pedro 1 Moriarty, Patrick M 1 Raal, Frederick J 1 Ray, Kausik K 1
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Pracoviště
Atherosclerosis and Lipoprotein Apher... 1 Centre for Cardiovascular Genetics In... 1 Department of Internal Medicine Erasm... 1 Department of Medicine and Robarts Re... 1 Department of Pharmacological and Bio... 1 Division of Translational Medicine an... 1 European Association for Cardiovascul... 1 Faculty of Health Sciences University... 1 Fundación Hipercolesterolemia Familia... 1 IRCCS Multimedica Milan Italy 1 International Atherosclerosis Society... 1 International Atherosclerosis Society... 1 Lipid Clinic Heart Institute Universi... 1 Lipid Disorders Clinic Royal Perth Ho... 1 McGill University Health Center Royal... 1 Molecular Genetics Lab Centre for Car... 1 National Cerebral and Cardiovascular ... 1 Nemours Cardiac Center A 1 DuPont Hos... 1 Osaka University Graduate School of M... 1 Pitié Sâlpetrière University Hospital... 1
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Autor
Al-Rasadi, Khalid 1 Barter, Philip J 1 Baum, Seth J 1 Catapano, Alberico L 1 Chapman, M John 1 Cuchel, Marina A 1 Defesche, Joep C 1 Folco, Emanuela 1 Freiberger, Tomas 1 Genest, Jacques 1 Gidding, Samuel S 1 Harada-Shiba, Mariko 1 Hegele, Robert A 1 Hovingh, G Kees 1 Humphries, Steve E 1 Jackson, Ann S 1 Mata, Pedro 1 Moriarty, Patrick M 1 Raal, Frederick J 1 Ray, Kausik K 1
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Pracoviště
Atherosclerosis and Lipoprotein Apher... 1 Centre for Cardiovascular Genetics In... 1 Department of Internal Medicine Erasm... 1 Department of Medicine and Robarts Re... 1 Department of Pharmacological and Bio... 1 Division of Translational Medicine an... 1 European Association for Cardiovascul... 1 Faculty of Health Sciences University... 1 Fundación Hipercolesterolemia Familia... 1 IRCCS Multimedica Milan Italy 1 International Atherosclerosis Society... 1 International Atherosclerosis Society... 1 Lipid Clinic Heart Institute Universi... 1 Lipid Disorders Clinic Royal Perth Ho... 1 McGill University Health Center Royal... 1 Molecular Genetics Lab Centre for Car... 1 National Cerebral and Cardiovascular ... 1 Nemours Cardiac Center A 1 DuPont Hos... 1 Osaka University Graduate School of M... 1 Pitié Sâlpetrière University Hospital... 1
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Familial hypercholesterolaemia is common in individuals who had a myocardial infarction at a young age. As many as one in 200 people could have heterozygous familial hypercholesterolaemia, and up to one in 300 000 individuals could be homozygous. The phenotypes of heterozygous and homozygous familial hypercholesterolaemia overlap considerably; the response to treatment is also heterogeneous. In this Review, we aim to define a phenotype for severe familial hypercholesterolaemia and identify people at highest risk for cardiovascular disease, based on the concentration of LDL cholesterol in blood and individuals' responsiveness to conventional lipid-lowering treatment. We assess the importance of molecular characterisation and define the role of other cardiovascular risk factors and advanced subclinical coronary atherosclerosis in risk stratification. Individuals with severe familial hypercholesterolaemia might benefit in particular from early and more aggressive cholesterol-lowering treatment (eg, with PCSK9 inhibitors). In addition to better tailored therapy, more precise characterisation of individuals with severe familial hypercholesterolaemia could improve resource use.
- MeSH
- hyperlipoproteinemie typ II komplikace epidemiologie terapie MeSH
- kardiovaskulární nemoci epidemiologie etiologie MeSH
- LDL-cholesterol krev MeSH
- lidé MeSH
- rizikové faktory MeSH
- směrnice pro lékařskou praxi jako téma MeSH
- společnosti lékařské MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
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