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Pracoviště: Neurology Department Faculty of Medicine Mazand...

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Článek

Disease Activity in Pregnant and Postpartum Women With Multiple Sclerosis Receiving Ocrelizumab or Other Disease-Modifying Therapies

Yeh, Wei Z
Autor Yeh, Wei Z ORCID From the Department of Neuroscience (W.Z.Y., A.V.D.W., H.B., V.G.J.), School of Translational Medicine, Monash University Department of Neurology (W.Z.Y., A.V.D.W., O.G.S., H.B., V.G.J.), Alfred Health, Melbourne Department of Neurology (O.G.S., K.B.), Box Hill Hospital Department of Neurosciences (O.G.S., K.B.), Eastern Health Clinical School, Monash University, Box Hill Neuroimmunology Centre (T.K.), Department of Neurology, Royal Melbourne Hospital CORe (T.K.), Department of Medicine, University of Melbourne, Australia Amiri Hospital (R.A.), Sharq, Kuwait Perron Institute for Neurological and Translational Science (A.G.K., M.J.F.-P., W.M.C.), University of Western Australia, Nedlands Centre for Molecular Medicine and Innovative Therapeutics (A.G.K., M.J.F.-P.), Murdoch University, Perth Sir Charles Gairdner Hospital (A.G.K., W.M.C.), QEIIMC, Nedlands University of Newcastle (J.L.-S.), Newcastle Hunter New England Health (J.L.-S.), John Hunter Hospital, New South Wales, Australia Karadeniz Technical University (C.B.), Medical Faculty, Trabzon Izmir University of Economics (S.O.), Medical Point Hospital, Izmir, Turkey University Hospital Center Zagreb (M.H.) University of Zagreb (M.H.), School of Medicine, Croatia Monash Health (N.A.J.) Department of Medicine (N.A.J.), School of Clinical Sciences, Monash University, Melbourne, Australia CHUM and Universite de Montreal (A.P., M.G., P.D.), Canada Neurology Department (S.M.B.), Faculty of Medicine, Mazandaran University of Medical Sciences, Iran University of New South Wales (Suzanne Hodgkinson), Sydney, Australia Cliniques Universitaires Saint-Luc (V.V.P.), Brussels Université Catholique de Louvain (V.V.P.) Universitary Hospital Ghent (G.L.) Department of Neurology (B.W.), Antwerp University Hospital, Edegem Translational Neurosciences Research Group (B.W.), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium CSSS Saint-Jérôme (J.P.), Saint-Jerome, Canada Department of Neuroscience (M.F.), Neurology Unit-MS Center, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy Department of Biotechnological and Applied Clinical Sciences (M.F.), University of L'Aquila, Italy Groene Hart Ziekenhuis (K.D.G.), Gouda, Netherlands Charles University in Prague and General University Hospital (D.H., E.K.H.), Prague, Czech Republic Yeditepe University Kosuyolu Hospital (R.K.), Neurological Sciences, Istanbul, Turkey Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania UOS Sclerosi Multipla (F.P.), AOU Policlinico "G Rodloico-San Marco", University of Catania, Italy University of Queensland (P.A.M.), Brisbane Royal Brisbane and Women's Hospital (P.A.M.), Australia Centro Sclerosi Multipla (D.M.), UOC Neurologia, Azienda Ospedaliera per l'Emergenza Cannizzaro, Catania, Italy Koc University (A.A.), Istanbul, Turkey Nemocnice Jihlava (Radek Ampapa), Jihlava, Czech Republic Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Avellino, Italy Zuyderland Medical Center (O.H.H.G.), Sittard-Geleen School for Mental Health and Neuroscience (O.H.H.G.), Maastricht University, The Netherlands Centro Hospitalar Universitario de Sao Joao (M.J.S.) Faculty of Health Sciences (M.J.S.), University Fernando Pessoa, Porto, Portugal Royal Victoria Hospital (Stella Hughes), Belfast, United Kingdom Department of Neurology (R.G., S.M.), Research laboratory LR18SP03, Clinical investigation Center Neurosciences and Mental Health, Razi Hospital Faculty of Medicine of Tunis (R.G., S.M.), University of Tunis El Manar, Tunis, Tunisia Austin Health (R.A.M.), Melbourne, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Azienda Sanitaria Unica Regionale Marche - AV3 (E.C.), Macerata, Italy Sultan Qaboos University (A.A.-A.), Al-Khodh, Oman Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey St. Michael's Hospital (J.O.), Toronto, Canada and F. Hoffmann-La Roche Ltd (E.M.-L.R., S.G., N.P.), Basel, Switzerland
Van Der Walt, Anneke
Autor Van Der Walt, Anneke ORCID From the Department of Neuroscience (W.Z.Y., A.V.D.W., H.B., V.G.J.), School of Translational Medicine, Monash University Department of Neurology (W.Z.Y., A.V.D.W., O.G.S., H.B., V.G.J.), Alfred Health, Melbourne Department of Neurology (O.G.S., K.B.), Box Hill Hospital Department of Neurosciences (O.G.S., K.B.), Eastern Health Clinical School, Monash University, Box Hill Neuroimmunology Centre (T.K.), Department of Neurology, Royal Melbourne Hospital CORe (T.K.), Department of Medicine, University of Melbourne, Australia Amiri Hospital (R.A.), Sharq, Kuwait Perron Institute for Neurological and Translational Science (A.G.K., M.J.F.-P., W.M.C.), University of Western Australia, Nedlands Centre for Molecular Medicine and Innovative Therapeutics (A.G.K., M.J.F.-P.), Murdoch University, Perth Sir Charles Gairdner Hospital (A.G.K., W.M.C.), QEIIMC, Nedlands University of Newcastle (J.L.-S.), Newcastle Hunter New England Health (J.L.-S.), John Hunter Hospital, New South Wales, Australia Karadeniz Technical University (C.B.), Medical Faculty, Trabzon Izmir University of Economics (S.O.), Medical Point Hospital, Izmir, Turkey University Hospital Center Zagreb (M.H.) University of Zagreb (M.H.), School of Medicine, Croatia Monash Health (N.A.J.) Department of Medicine (N.A.J.), School of Clinical Sciences, Monash University, Melbourne, Australia CHUM and Universite de Montreal (A.P., M.G., P.D.), Canada Neurology Department (S.M.B.), Faculty of Medicine, Mazandaran University of Medical Sciences, Iran University of New South Wales (Suzanne Hodgkinson), Sydney, Australia Cliniques Universitaires Saint-Luc (V.V.P.), Brussels Université Catholique de Louvain (V.V.P.) Universitary Hospital Ghent (G.L.) Department of Neurology (B.W.), Antwerp University Hospital, Edegem Translational Neurosciences Research Group (B.W.), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium CSSS Saint-Jérôme (J.P.), Saint-Jerome, Canada Department of Neuroscience (M.F.), Neurology Unit-MS Center, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy Department of Biotechnological and Applied Clinical Sciences (M.F.), University of L'Aquila, Italy Groene Hart Ziekenhuis (K.D.G.), Gouda, Netherlands Charles University in Prague and General University Hospital (D.H., E.K.H.), Prague, Czech Republic Yeditepe University Kosuyolu Hospital (R.K.), Neurological Sciences, Istanbul, Turkey Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania UOS Sclerosi Multipla (F.P.), AOU Policlinico "G Rodloico-San Marco", University of Catania, Italy University of Queensland (P.A.M.), Brisbane Royal Brisbane and Women's Hospital (P.A.M.), Australia Centro Sclerosi Multipla (D.M.), UOC Neurologia, Azienda Ospedaliera per l'Emergenza Cannizzaro, Catania, Italy Koc University (A.A.), Istanbul, Turkey Nemocnice Jihlava (Radek Ampapa), Jihlava, Czech Republic Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Avellino, Italy Zuyderland Medical Center (O.H.H.G.), Sittard-Geleen School for Mental Health and Neuroscience (O.H.H.G.), Maastricht University, The Netherlands Centro Hospitalar Universitario de Sao Joao (M.J.S.) Faculty of Health Sciences (M.J.S.), University Fernando Pessoa, Porto, Portugal Royal Victoria Hospital (Stella Hughes), Belfast, United Kingdom Department of Neurology (R.G., S.M.), Research laboratory LR18SP03, Clinical investigation Center Neurosciences and Mental Health, Razi Hospital Faculty of Medicine of Tunis (R.G., S.M.), University of Tunis El Manar, Tunis, Tunisia Austin Health (R.A.M.), Melbourne, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Azienda Sanitaria Unica Regionale Marche - AV3 (E.C.), Macerata, Italy Sultan Qaboos University (A.A.-A.), Al-Khodh, Oman Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey St. Michael's Hospital (J.O.), Toronto, Canada and F. Hoffmann-La Roche Ltd (E.M.-L.R., S.G., N.P.), Basel, Switzerland
Skibina, Olga G
Autor Skibina, Olga G ORCID From the Department of Neuroscience (W.Z.Y., A.V.D.W., H.B., V.G.J.), School of Translational Medicine, Monash University Department of Neurology (W.Z.Y., A.V.D.W., O.G.S., H.B., V.G.J.), Alfred Health, Melbourne Department of Neurology (O.G.S., K.B.), Box Hill Hospital Department of Neurosciences (O.G.S., K.B.), Eastern Health Clinical School, Monash University, Box Hill Neuroimmunology Centre (T.K.), Department of Neurology, Royal Melbourne Hospital CORe (T.K.), Department of Medicine, University of Melbourne, Australia Amiri Hospital (R.A.), Sharq, Kuwait Perron Institute for Neurological and Translational Science (A.G.K., M.J.F.-P., W.M.C.), University of Western Australia, Nedlands Centre for Molecular Medicine and Innovative Therapeutics (A.G.K., M.J.F.-P.), Murdoch University, Perth Sir Charles Gairdner Hospital (A.G.K., W.M.C.), QEIIMC, Nedlands University of Newcastle (J.L.-S.), Newcastle Hunter New England Health (J.L.-S.), John Hunter Hospital, New South Wales, Australia Karadeniz Technical University (C.B.), Medical Faculty, Trabzon Izmir University of Economics (S.O.), Medical Point Hospital, Izmir, Turkey University Hospital Center Zagreb (M.H.) University of Zagreb (M.H.), School of Medicine, Croatia Monash Health (N.A.J.) Department of Medicine (N.A.J.), School of Clinical Sciences, Monash University, Melbourne, Australia CHUM and Universite de Montreal (A.P., M.G., P.D.), Canada Neurology Department (S.M.B.), Faculty of Medicine, Mazandaran University of Medical Sciences, Iran University of New South Wales (Suzanne Hodgkinson), Sydney, Australia Cliniques Universitaires Saint-Luc (V.V.P.), Brussels Université Catholique de Louvain (V.V.P.) Universitary Hospital Ghent (G.L.) Department of Neurology (B.W.), Antwerp University Hospital, Edegem Translational Neurosciences Research Group (B.W.), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium CSSS Saint-Jérôme (J.P.), Saint-Jerome, Canada Department of Neuroscience (M.F.), Neurology Unit-MS Center, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy Department of Biotechnological and Applied Clinical Sciences (M.F.), University of L'Aquila, Italy Groene Hart Ziekenhuis (K.D.G.), Gouda, Netherlands Charles University in Prague and General University Hospital (D.H., E.K.H.), Prague, Czech Republic Yeditepe University Kosuyolu Hospital (R.K.), Neurological Sciences, Istanbul, Turkey Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania UOS Sclerosi Multipla (F.P.), AOU Policlinico "G Rodloico-San Marco", University of Catania, Italy University of Queensland (P.A.M.), Brisbane Royal Brisbane and Women's Hospital (P.A.M.), Australia Centro Sclerosi Multipla (D.M.), UOC Neurologia, Azienda Ospedaliera per l'Emergenza Cannizzaro, Catania, Italy Koc University (A.A.), Istanbul, Turkey Nemocnice Jihlava (Radek Ampapa), Jihlava, Czech Republic Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Avellino, Italy Zuyderland Medical Center (O.H.H.G.), Sittard-Geleen School for Mental Health and Neuroscience (O.H.H.G.), Maastricht University, The Netherlands Centro Hospitalar Universitario de Sao Joao (M.J.S.) Faculty of Health Sciences (M.J.S.), University Fernando Pessoa, Porto, Portugal Royal Victoria Hospital (Stella Hughes), Belfast, United Kingdom Department of Neurology (R.G., S.M.), Research laboratory LR18SP03, Clinical investigation Center Neurosciences and Mental Health, Razi Hospital Faculty of Medicine of Tunis (R.G., S.M.), University of Tunis El Manar, Tunis, Tunisia Austin Health (R.A.M.), Melbourne, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Azienda Sanitaria Unica Regionale Marche - AV3 (E.C.), Macerata, Italy Sultan Qaboos University (A.A.-A.), Al-Khodh, Oman Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey St. Michael's Hospital (J.O.), Toronto, Canada and F. Hoffmann-La Roche Ltd (E.M.-L.R., S.G., N.P.), Basel, Switzerland
Kalincik, Tomas
Autor Autorita ORCID From the Department of Neuroscience (W.Z.Y., A.V.D.W., H.B., V.G.J.), School of Translational Medicine, Monash University Department of Neurology (W.Z.Y., A.V.D.W., O.G.S., H.B., V.G.J.), Alfred Health, Melbourne Department of Neurology (O.G.S., K.B.), Box Hill Hospital Department of Neurosciences (O.G.S., K.B.), Eastern Health Clinical School, Monash University, Box Hill Neuroimmunology Centre (T.K.), Department of Neurology, Royal Melbourne Hospital CORe (T.K.), Department of Medicine, University of Melbourne, Australia Amiri Hospital (R.A.), Sharq, Kuwait Perron Institute for Neurological and Translational Science (A.G.K., M.J.F.-P., W.M.C.), University of Western Australia, Nedlands Centre for Molecular Medicine and Innovative Therapeutics (A.G.K., M.J.F.-P.), Murdoch University, Perth Sir Charles Gairdner Hospital (A.G.K., W.M.C.), QEIIMC, Nedlands University of Newcastle (J.L.-S.), Newcastle Hunter New England Health (J.L.-S.), John Hunter Hospital, New South Wales, Australia Karadeniz Technical University (C.B.), Medical Faculty, Trabzon Izmir University of Economics (S.O.), Medical Point Hospital, Izmir, Turkey University Hospital Center Zagreb (M.H.) University of Zagreb (M.H.), School of Medicine, Croatia Monash Health (N.A.J.) Department of Medicine (N.A.J.), School of Clinical Sciences, Monash University, Melbourne, Australia CHUM and Universite de Montreal (A.P., M.G., P.D.), Canada Neurology Department (S.M.B.), Faculty of Medicine, Mazandaran University of Medical Sciences, Iran University of New South Wales (Suzanne Hodgkinson), Sydney, Australia Cliniques Universitaires Saint-Luc (V.V.P.), Brussels Université Catholique de Louvain (V.V.P.) Universitary Hospital Ghent (G.L.) Department of Neurology (B.W.), Antwerp University Hospital, Edegem Translational Neurosciences Research Group (B.W.), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium CSSS Saint-Jérôme (J.P.), Saint-Jerome, Canada Department of Neuroscience (M.F.), Neurology Unit-MS Center, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy Department of Biotechnological and Applied Clinical Sciences (M.F.), University of L'Aquila, Italy Groene Hart Ziekenhuis (K.D.G.), Gouda, Netherlands Charles University in Prague and General University Hospital (D.H., E.K.H.), Prague, Czech Republic Yeditepe University Kosuyolu Hospital (R.K.), Neurological Sciences, Istanbul, Turkey Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania UOS Sclerosi Multipla (F.P.), AOU Policlinico "G Rodloico-San Marco", University of Catania, Italy University of Queensland (P.A.M.), Brisbane Royal Brisbane and Women's Hospital (P.A.M.), Australia Centro Sclerosi Multipla (D.M.), UOC Neurologia, Azienda Ospedaliera per l'Emergenza Cannizzaro, Catania, Italy Koc University (A.A.), Istanbul, Turkey Nemocnice Jihlava (Radek Ampapa), Jihlava, Czech Republic Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Avellino, Italy Zuyderland Medical Center (O.H.H.G.), Sittard-Geleen School for Mental Health and Neuroscience (O.H.H.G.), Maastricht University, The Netherlands Centro Hospitalar Universitario de Sao Joao (M.J.S.) Faculty of Health Sciences (M.J.S.), University Fernando Pessoa, Porto, Portugal Royal Victoria Hospital (Stella Hughes), Belfast, United Kingdom Department of Neurology (R.G., S.M.), Research laboratory LR18SP03, Clinical investigation Center Neurosciences and Mental Health, Razi Hospital Faculty of Medicine of Tunis (R.G., S.M.), University of Tunis El Manar, Tunis, Tunisia Austin Health (R.A.M.), Melbourne, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Azienda Sanitaria Unica Regionale Marche - AV3 (E.C.), Macerata, Italy Sultan Qaboos University (A.A.-A.), Al-Khodh, Oman Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey St. Michael's Hospital (J.O.), Toronto, Canada and F. Hoffmann-La Roche Ltd (E.M.-L.R., S.G., N.P.), Basel, Switzerland
Alroughani, Raed
Autor Alroughani, Raed ORCID From the Department of Neuroscience (W.Z.Y., A.V.D.W., H.B., V.G.J.), School of Translational Medicine, Monash University Department of Neurology (W.Z.Y., A.V.D.W., O.G.S., H.B., V.G.J.), Alfred Health, Melbourne Department of Neurology (O.G.S., K.B.), Box Hill Hospital Department of Neurosciences (O.G.S., K.B.), Eastern Health Clinical School, Monash University, Box Hill Neuroimmunology Centre (T.K.), Department of Neurology, Royal Melbourne Hospital CORe (T.K.), Department of Medicine, University of Melbourne, Australia Amiri Hospital (R.A.), Sharq, Kuwait Perron Institute for Neurological and Translational Science (A.G.K., M.J.F.-P., W.M.C.), University of Western Australia, Nedlands Centre for Molecular Medicine and Innovative Therapeutics (A.G.K., M.J.F.-P.), Murdoch University, Perth Sir Charles Gairdner Hospital (A.G.K., W.M.C.), QEIIMC, Nedlands University of Newcastle (J.L.-S.), Newcastle Hunter New England Health (J.L.-S.), John Hunter Hospital, New South Wales, Australia Karadeniz Technical University (C.B.), Medical Faculty, Trabzon Izmir University of Economics (S.O.), Medical Point Hospital, Izmir, Turkey University Hospital Center Zagreb (M.H.) University of Zagreb (M.H.), School of Medicine, Croatia Monash Health (N.A.J.) Department of Medicine (N.A.J.), School of Clinical Sciences, Monash University, Melbourne, Australia CHUM and Universite de Montreal (A.P., M.G., P.D.), Canada Neurology Department (S.M.B.), Faculty of Medicine, Mazandaran University of Medical Sciences, Iran University of New South Wales (Suzanne Hodgkinson), Sydney, Australia Cliniques Universitaires Saint-Luc (V.V.P.), Brussels Université Catholique de Louvain (V.V.P.) Universitary Hospital Ghent (G.L.) Department of Neurology (B.W.), Antwerp University Hospital, Edegem Translational Neurosciences Research Group (B.W.), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium CSSS Saint-Jérôme (J.P.), Saint-Jerome, Canada Department of Neuroscience (M.F.), Neurology Unit-MS Center, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy Department of Biotechnological and Applied Clinical Sciences (M.F.), University of L'Aquila, Italy Groene Hart Ziekenhuis (K.D.G.), Gouda, Netherlands Charles University in Prague and General University Hospital (D.H., E.K.H.), Prague, Czech Republic Yeditepe University Kosuyolu Hospital (R.K.), Neurological Sciences, Istanbul, Turkey Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania UOS Sclerosi Multipla (F.P.), AOU Policlinico "G Rodloico-San Marco", University of Catania, Italy University of Queensland (P.A.M.), Brisbane Royal Brisbane and Women's Hospital (P.A.M.), Australia Centro Sclerosi Multipla (D.M.), UOC Neurologia, Azienda Ospedaliera per l'Emergenza Cannizzaro, Catania, Italy Koc University (A.A.), Istanbul, Turkey Nemocnice Jihlava (Radek Ampapa), Jihlava, Czech Republic Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Avellino, Italy Zuyderland Medical Center (O.H.H.G.), Sittard-Geleen School for Mental Health and Neuroscience (O.H.H.G.), Maastricht University, The Netherlands Centro Hospitalar Universitario de Sao Joao (M.J.S.) Faculty of Health Sciences (M.J.S.), University Fernando Pessoa, Porto, Portugal Royal Victoria Hospital (Stella Hughes), Belfast, United Kingdom Department of Neurology (R.G., S.M.), Research laboratory LR18SP03, Clinical investigation Center Neurosciences and Mental Health, Razi Hospital Faculty of Medicine of Tunis (R.G., S.M.), University of Tunis El Manar, Tunis, Tunisia Austin Health (R.A.M.), Melbourne, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Azienda Sanitaria Unica Regionale Marche - AV3 (E.C.), Macerata, Italy Sultan Qaboos University (A.A.-A.), Al-Khodh, Oman Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey St. Michael's Hospital (J.O.), Toronto, Canada and F. Hoffmann-La Roche Ltd (E.M.-L.R., S.G., N.P.), Basel, Switzerland
Kermode, Allan G
Autor Kermode, Allan G ORCID From the Department of Neuroscience (W.Z.Y., A.V.D.W., H.B., V.G.J.), School of Translational Medicine, Monash University Department of Neurology (W.Z.Y., A.V.D.W., O.G.S., H.B., V.G.J.), Alfred Health, Melbourne Department of Neurology (O.G.S., K.B.), Box Hill Hospital Department of Neurosciences (O.G.S., K.B.), Eastern Health Clinical School, Monash University, Box Hill Neuroimmunology Centre (T.K.), Department of Neurology, Royal Melbourne Hospital CORe (T.K.), Department of Medicine, University of Melbourne, Australia Amiri Hospital (R.A.), Sharq, Kuwait Perron Institute for Neurological and Translational Science (A.G.K., M.J.F.-P., W.M.C.), University of Western Australia, Nedlands Centre for Molecular Medicine and Innovative Therapeutics (A.G.K., M.J.F.-P.), Murdoch University, Perth Sir Charles Gairdner Hospital (A.G.K., W.M.C.), QEIIMC, Nedlands University of Newcastle (J.L.-S.), Newcastle Hunter New England Health (J.L.-S.), John Hunter Hospital, New South Wales, Australia Karadeniz Technical University (C.B.), Medical Faculty, Trabzon Izmir University of Economics (S.O.), Medical Point Hospital, Izmir, Turkey University Hospital Center Zagreb (M.H.) University of Zagreb (M.H.), School of Medicine, Croatia Monash Health (N.A.J.) Department of Medicine (N.A.J.), School of Clinical Sciences, Monash University, Melbourne, Australia CHUM and Universite de Montreal (A.P., M.G., P.D.), Canada Neurology Department (S.M.B.), Faculty of Medicine, Mazandaran University of Medical Sciences, Iran University of New South Wales (Suzanne Hodgkinson), Sydney, Australia Cliniques Universitaires Saint-Luc (V.V.P.), Brussels Université Catholique de Louvain (V.V.P.) Universitary Hospital Ghent (G.L.) Department of Neurology (B.W.), Antwerp University Hospital, Edegem Translational Neurosciences Research Group (B.W.), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium CSSS Saint-Jérôme (J.P.), Saint-Jerome, Canada Department of Neuroscience (M.F.), Neurology Unit-MS Center, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy Department of Biotechnological and Applied Clinical Sciences (M.F.), University of L'Aquila, Italy Groene Hart Ziekenhuis (K.D.G.), Gouda, Netherlands Charles University in Prague and General University Hospital (D.H., E.K.H.), Prague, Czech Republic Yeditepe University Kosuyolu Hospital (R.K.), Neurological Sciences, Istanbul, Turkey Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania UOS Sclerosi Multipla (F.P.), AOU Policlinico "G Rodloico-San Marco", University of Catania, Italy University of Queensland (P.A.M.), Brisbane Royal Brisbane and Women's Hospital (P.A.M.), Australia Centro Sclerosi Multipla (D.M.), UOC Neurologia, Azienda Ospedaliera per l'Emergenza Cannizzaro, Catania, Italy Koc University (A.A.), Istanbul, Turkey Nemocnice Jihlava (Radek Ampapa), Jihlava, Czech Republic Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Avellino, Italy Zuyderland Medical Center (O.H.H.G.), Sittard-Geleen School for Mental Health and Neuroscience (O.H.H.G.), Maastricht University, The Netherlands Centro Hospitalar Universitario de Sao Joao (M.J.S.) Faculty of Health Sciences (M.J.S.), University Fernando Pessoa, Porto, Portugal Royal Victoria Hospital (Stella Hughes), Belfast, United Kingdom Department of Neurology (R.G., S.M.), Research laboratory LR18SP03, Clinical investigation Center Neurosciences and Mental Health, Razi Hospital Faculty of Medicine of Tunis (R.G., S.M.), University of Tunis El Manar, Tunis, Tunisia Austin Health (R.A.M.), Melbourne, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Azienda Sanitaria Unica Regionale Marche - AV3 (E.C.), Macerata, Italy Sultan Qaboos University (A.A.-A.), Al-Khodh, Oman Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey St. Michael's Hospital (J.O.), Toronto, Canada and F. Hoffmann-La Roche Ltd (E.M.-L.R., S.G., N.P.), Basel, Switzerland
Fabis-Pedrini, Marzena J
Autor Fabis-Pedrini, Marzena J From the Department of Neuroscience (W.Z.Y., A.V.D.W., H.B., V.G.J.), School of Translational Medicine, Monash University Department of Neurology (W.Z.Y., A.V.D.W., O.G.S., H.B., V.G.J.), Alfred Health, Melbourne Department of Neurology (O.G.S., K.B.), Box Hill Hospital Department of Neurosciences (O.G.S., K.B.), Eastern Health Clinical School, Monash University, Box Hill Neuroimmunology Centre (T.K.), Department of Neurology, Royal Melbourne Hospital CORe (T.K.), Department of Medicine, University of Melbourne, Australia Amiri Hospital (R.A.), Sharq, Kuwait Perron Institute for Neurological and Translational Science (A.G.K., M.J.F.-P., W.M.C.), University of Western Australia, Nedlands Centre for Molecular Medicine and Innovative Therapeutics (A.G.K., M.J.F.-P.), Murdoch University, Perth Sir Charles Gairdner Hospital (A.G.K., W.M.C.), QEIIMC, Nedlands University of Newcastle (J.L.-S.), Newcastle Hunter New England Health (J.L.-S.), John Hunter Hospital, New South Wales, Australia Karadeniz Technical University (C.B.), Medical Faculty, Trabzon Izmir University of Economics (S.O.), Medical Point Hospital, Izmir, Turkey University Hospital Center Zagreb (M.H.) University of Zagreb (M.H.), School of Medicine, Croatia Monash Health (N.A.J.) Department of Medicine (N.A.J.), School of Clinical Sciences, Monash University, Melbourne, Australia CHUM and Universite de Montreal (A.P., M.G., P.D.), Canada Neurology Department (S.M.B.), Faculty of Medicine, Mazandaran University of Medical Sciences, Iran University of New South Wales (Suzanne Hodgkinson), Sydney, Australia Cliniques Universitaires Saint-Luc (V.V.P.), Brussels Université Catholique de Louvain (V.V.P.) Universitary Hospital Ghent (G.L.) Department of Neurology (B.W.), Antwerp University Hospital, Edegem Translational Neurosciences Research Group (B.W.), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium CSSS Saint-Jérôme (J.P.), Saint-Jerome, Canada Department of Neuroscience (M.F.), Neurology Unit-MS Center, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy Department of Biotechnological and Applied Clinical Sciences (M.F.), University of L'Aquila, Italy Groene Hart Ziekenhuis (K.D.G.), Gouda, Netherlands Charles University in Prague and General University Hospital (D.H., E.K.H.), Prague, Czech Republic Yeditepe University Kosuyolu Hospital (R.K.), Neurological Sciences, Istanbul, Turkey Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania UOS Sclerosi Multipla (F.P.), AOU Policlinico "G Rodloico-San Marco", University of Catania, Italy University of Queensland (P.A.M.), Brisbane Royal Brisbane and Women's Hospital (P.A.M.), Australia Centro Sclerosi Multipla (D.M.), UOC Neurologia, Azienda Ospedaliera per l'Emergenza Cannizzaro, Catania, Italy Koc University (A.A.), Istanbul, Turkey Nemocnice Jihlava (Radek Ampapa), Jihlava, Czech Republic Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Avellino, Italy Zuyderland Medical Center (O.H.H.G.), Sittard-Geleen School for Mental Health and Neuroscience (O.H.H.G.), Maastricht University, The Netherlands Centro Hospitalar Universitario de Sao Joao (M.J.S.) Faculty of Health Sciences (M.J.S.), University Fernando Pessoa, Porto, Portugal Royal Victoria Hospital (Stella Hughes), Belfast, United Kingdom Department of Neurology (R.G., S.M.), Research laboratory LR18SP03, Clinical investigation Center Neurosciences and Mental Health, Razi Hospital Faculty of Medicine of Tunis (R.G., S.M.), University of Tunis El Manar, Tunis, Tunisia Austin Health (R.A.M.), Melbourne, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Azienda Sanitaria Unica Regionale Marche - AV3 (E.C.), Macerata, Italy Sultan Qaboos University (A.A.-A.), Al-Khodh, Oman Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey St. Michael's Hospital (J.O.), Toronto, Canada and F. Hoffmann-La Roche Ltd (E.M.-L.R., S.G., N.P.), Basel, Switzerland
Carroll, William M
Autor Carroll, William M ORCID From the Department of Neuroscience (W.Z.Y., A.V.D.W., H.B., V.G.J.), School of Translational Medicine, Monash University Department of Neurology (W.Z.Y., A.V.D.W., O.G.S., H.B., V.G.J.), Alfred Health, Melbourne Department of Neurology (O.G.S., K.B.), Box Hill Hospital Department of Neurosciences (O.G.S., K.B.), Eastern Health Clinical School, Monash University, Box Hill Neuroimmunology Centre (T.K.), Department of Neurology, Royal Melbourne Hospital CORe (T.K.), Department of Medicine, University of Melbourne, Australia Amiri Hospital (R.A.), Sharq, Kuwait Perron Institute for Neurological and Translational Science (A.G.K., M.J.F.-P., W.M.C.), University of Western Australia, Nedlands Centre for Molecular Medicine and Innovative Therapeutics (A.G.K., M.J.F.-P.), Murdoch University, Perth Sir Charles Gairdner Hospital (A.G.K., W.M.C.), QEIIMC, Nedlands University of Newcastle (J.L.-S.), Newcastle Hunter New England Health (J.L.-S.), John Hunter Hospital, New South Wales, Australia Karadeniz Technical University (C.B.), Medical Faculty, Trabzon Izmir University of Economics (S.O.), Medical Point Hospital, Izmir, Turkey University Hospital Center Zagreb (M.H.) University of Zagreb (M.H.), School of Medicine, Croatia Monash Health (N.A.J.) Department of Medicine (N.A.J.), School of Clinical Sciences, Monash University, Melbourne, Australia CHUM and Universite de Montreal (A.P., M.G., P.D.), Canada Neurology Department (S.M.B.), Faculty of Medicine, Mazandaran University of Medical Sciences, Iran University of New South Wales (Suzanne Hodgkinson), Sydney, Australia Cliniques Universitaires Saint-Luc (V.V.P.), Brussels Université Catholique de Louvain (V.V.P.) Universitary Hospital Ghent (G.L.) Department of Neurology (B.W.), Antwerp University Hospital, Edegem Translational Neurosciences Research Group (B.W.), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium CSSS Saint-Jérôme (J.P.), Saint-Jerome, Canada Department of Neuroscience (M.F.), Neurology Unit-MS Center, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy Department of Biotechnological and Applied Clinical Sciences (M.F.), University of L'Aquila, Italy Groene Hart Ziekenhuis (K.D.G.), Gouda, Netherlands Charles University in Prague and General University Hospital (D.H., E.K.H.), Prague, Czech Republic Yeditepe University Kosuyolu Hospital (R.K.), Neurological Sciences, Istanbul, Turkey Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania UOS Sclerosi Multipla (F.P.), AOU Policlinico "G Rodloico-San Marco", University of Catania, Italy University of Queensland (P.A.M.), Brisbane Royal Brisbane and Women's Hospital (P.A.M.), Australia Centro Sclerosi Multipla (D.M.), UOC Neurologia, Azienda Ospedaliera per l'Emergenza Cannizzaro, Catania, Italy Koc University (A.A.), Istanbul, Turkey Nemocnice Jihlava (Radek Ampapa), Jihlava, Czech Republic Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Avellino, Italy Zuyderland Medical Center (O.H.H.G.), Sittard-Geleen School for Mental Health and Neuroscience (O.H.H.G.), Maastricht University, The Netherlands Centro Hospitalar Universitario de Sao Joao (M.J.S.) Faculty of Health Sciences (M.J.S.), University Fernando Pessoa, Porto, Portugal Royal Victoria Hospital (Stella Hughes), Belfast, United Kingdom Department of Neurology (R.G., S.M.), Research laboratory LR18SP03, Clinical investigation Center Neurosciences and Mental Health, Razi Hospital Faculty of Medicine of Tunis (R.G., S.M.), University of Tunis El Manar, Tunis, Tunisia Austin Health (R.A.M.), Melbourne, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Azienda Sanitaria Unica Regionale Marche - AV3 (E.C.), Macerata, Italy Sultan Qaboos University (A.A.-A.), Al-Khodh, Oman Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey St. Michael's Hospital (J.O.), Toronto, Canada and F. Hoffmann-La Roche Ltd (E.M.-L.R., S.G., N.P.), Basel, Switzerland
Lechner-Scott, Jeannette
Autor Lechner-Scott, Jeannette ORCID From the Department of Neuroscience (W.Z.Y., A.V.D.W., H.B., V.G.J.), School of Translational Medicine, Monash University Department of Neurology (W.Z.Y., A.V.D.W., O.G.S., H.B., V.G.J.), Alfred Health, Melbourne Department of Neurology (O.G.S., K.B.), Box Hill Hospital Department of Neurosciences (O.G.S., K.B.), Eastern Health Clinical School, Monash University, Box Hill Neuroimmunology Centre (T.K.), Department of Neurology, Royal Melbourne Hospital CORe (T.K.), Department of Medicine, University of Melbourne, Australia Amiri Hospital (R.A.), Sharq, Kuwait Perron Institute for Neurological and Translational Science (A.G.K., M.J.F.-P., W.M.C.), University of Western Australia, Nedlands Centre for Molecular Medicine and Innovative Therapeutics (A.G.K., M.J.F.-P.), Murdoch University, Perth Sir Charles Gairdner Hospital (A.G.K., W.M.C.), QEIIMC, Nedlands University of Newcastle (J.L.-S.), Newcastle Hunter New England Health (J.L.-S.), John Hunter Hospital, New South Wales, Australia Karadeniz Technical University (C.B.), Medical Faculty, Trabzon Izmir University of Economics (S.O.), Medical Point Hospital, Izmir, Turkey University Hospital Center Zagreb (M.H.) University of Zagreb (M.H.), School of Medicine, Croatia Monash Health (N.A.J.) Department of Medicine (N.A.J.), School of Clinical Sciences, Monash University, Melbourne, Australia CHUM and Universite de Montreal (A.P., M.G., P.D.), Canada Neurology Department (S.M.B.), Faculty of Medicine, Mazandaran University of Medical Sciences, Iran University of New South Wales (Suzanne Hodgkinson), Sydney, Australia Cliniques Universitaires Saint-Luc (V.V.P.), Brussels Université Catholique de Louvain (V.V.P.) Universitary Hospital Ghent (G.L.) Department of Neurology (B.W.), Antwerp University Hospital, Edegem Translational Neurosciences Research Group (B.W.), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium CSSS Saint-Jérôme (J.P.), Saint-Jerome, Canada Department of Neuroscience (M.F.), Neurology Unit-MS Center, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy Department of Biotechnological and Applied Clinical Sciences (M.F.), University of L'Aquila, Italy Groene Hart Ziekenhuis (K.D.G.), Gouda, Netherlands Charles University in Prague and General University Hospital (D.H., E.K.H.), Prague, Czech Republic Yeditepe University Kosuyolu Hospital (R.K.), Neurological Sciences, Istanbul, Turkey Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania UOS Sclerosi Multipla (F.P.), AOU Policlinico "G Rodloico-San Marco", University of Catania, Italy University of Queensland (P.A.M.), Brisbane Royal Brisbane and Women's Hospital (P.A.M.), Australia Centro Sclerosi Multipla (D.M.), UOC Neurologia, Azienda Ospedaliera per l'Emergenza Cannizzaro, Catania, Italy Koc University (A.A.), Istanbul, Turkey Nemocnice Jihlava (Radek Ampapa), Jihlava, Czech Republic Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Avellino, Italy Zuyderland Medical Center (O.H.H.G.), Sittard-Geleen School for Mental Health and Neuroscience (O.H.H.G.), Maastricht University, The Netherlands Centro Hospitalar Universitario de Sao Joao (M.J.S.) Faculty of Health Sciences (M.J.S.), University Fernando Pessoa, Porto, Portugal Royal Victoria Hospital (Stella Hughes), Belfast, United Kingdom Department of Neurology (R.G., S.M.), Research laboratory LR18SP03, Clinical investigation Center Neurosciences and Mental Health, Razi Hospital Faculty of Medicine of Tunis (R.G., S.M.), University of Tunis El Manar, Tunis, Tunisia Austin Health (R.A.M.), Melbourne, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Azienda Sanitaria Unica Regionale Marche - AV3 (E.C.), Macerata, Italy Sultan Qaboos University (A.A.-A.), Al-Khodh, Oman Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey St. Michael's Hospital (J.O.), Toronto, Canada and F. Hoffmann-La Roche Ltd (E.M.-L.R., S.G., N.P.), Basel, Switzerland
Boz, Cavit
Autor Boz, Cavit ORCID From the Department of Neuroscience (W.Z.Y., A.V.D.W., H.B., V.G.J.), School of Translational Medicine, Monash University Department of Neurology (W.Z.Y., A.V.D.W., O.G.S., H.B., V.G.J.), Alfred Health, Melbourne Department of Neurology (O.G.S., K.B.), Box Hill Hospital Department of Neurosciences (O.G.S., K.B.), Eastern Health Clinical School, Monash University, Box Hill Neuroimmunology Centre (T.K.), Department of Neurology, Royal Melbourne Hospital CORe (T.K.), Department of Medicine, University of Melbourne, Australia Amiri Hospital (R.A.), Sharq, Kuwait Perron Institute for Neurological and Translational Science (A.G.K., M.J.F.-P., W.M.C.), University of Western Australia, Nedlands Centre for Molecular Medicine and Innovative Therapeutics (A.G.K., M.J.F.-P.), Murdoch University, Perth Sir Charles Gairdner Hospital (A.G.K., W.M.C.), QEIIMC, Nedlands University of Newcastle (J.L.-S.), Newcastle Hunter New England Health (J.L.-S.), John Hunter Hospital, New South Wales, Australia Karadeniz Technical University (C.B.), Medical Faculty, Trabzon Izmir University of Economics (S.O.), Medical Point Hospital, Izmir, Turkey University Hospital Center Zagreb (M.H.) University of Zagreb (M.H.), School of Medicine, Croatia Monash Health (N.A.J.) Department of Medicine (N.A.J.), School of Clinical Sciences, Monash University, Melbourne, Australia CHUM and Universite de Montreal (A.P., M.G., P.D.), Canada Neurology Department (S.M.B.), Faculty of Medicine, Mazandaran University of Medical Sciences, Iran University of New South Wales (Suzanne Hodgkinson), Sydney, Australia Cliniques Universitaires Saint-Luc (V.V.P.), Brussels Université Catholique de Louvain (V.V.P.) Universitary Hospital Ghent (G.L.) Department of Neurology (B.W.), Antwerp University Hospital, Edegem Translational Neurosciences Research Group (B.W.), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium CSSS Saint-Jérôme (J.P.), Saint-Jerome, Canada Department of Neuroscience (M.F.), Neurology Unit-MS Center, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy Department of Biotechnological and Applied Clinical Sciences (M.F.), University of L'Aquila, Italy Groene Hart Ziekenhuis (K.D.G.), Gouda, Netherlands Charles University in Prague and General University Hospital (D.H., E.K.H.), Prague, Czech Republic Yeditepe University Kosuyolu Hospital (R.K.), Neurological Sciences, Istanbul, Turkey Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania UOS Sclerosi Multipla (F.P.), AOU Policlinico "G Rodloico-San Marco", University of Catania, Italy University of Queensland (P.A.M.), Brisbane Royal Brisbane and Women's Hospital (P.A.M.), Australia Centro Sclerosi Multipla (D.M.), UOC Neurologia, Azienda Ospedaliera per l'Emergenza Cannizzaro, Catania, Italy Koc University (A.A.), Istanbul, Turkey Nemocnice Jihlava (Radek Ampapa), Jihlava, Czech Republic Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Avellino, Italy Zuyderland Medical Center (O.H.H.G.), Sittard-Geleen School for Mental Health and Neuroscience (O.H.H.G.), Maastricht University, The Netherlands Centro Hospitalar Universitario de Sao Joao (M.J.S.) Faculty of Health Sciences (M.J.S.), University Fernando Pessoa, Porto, Portugal Royal Victoria Hospital (Stella Hughes), Belfast, United Kingdom Department of Neurology (R.G., S.M.), Research laboratory LR18SP03, Clinical investigation Center Neurosciences and Mental Health, Razi Hospital Faculty of Medicine of Tunis (R.G., S.M.), University of Tunis El Manar, Tunis, Tunisia Austin Health (R.A.M.), Melbourne, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Azienda Sanitaria Unica Regionale Marche - AV3 (E.C.), Macerata, Italy Sultan Qaboos University (A.A.-A.), Al-Khodh, Oman Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey St. Michael's Hospital (J.O.), Toronto, Canada and F. Hoffmann-La Roche Ltd (E.M.-L.R., S.G., N.P.), Basel, Switzerland

Neurology® neuroimmunology & neuroinflammation. 2024 ; 11 (6) : e200328. [pub] 20241023

Neurol Neuroimmunol Neuroinflamm
ISSN 2332-7812
Medvik
Zdroj

BACKGROUND AND OBJECTIVES: Women with multiple sclerosis (MS) are at risk of disease reactivation in the early postpartum period. Ocrelizumab (OCR) is an anti-CD20 therapy highly effective at reducing MS disease activity. Data remain limited regarding use of disease-modifying therapies (DMTs), including OCR, and disease activity during peripregnancy periods. METHODS: We performed a retrospective cohort study using data from the MSBase Registry including pregnancies conceived after December 31, 2010, from women aged 18 years and older, with relapsing-remitting MS or clinically isolated syndrome. Women were classified by preconception exposure to DMTs, including OCR, rituximab (RTX), natalizumab (NAT), stratified into active (NAT-A; continued ≥28 weeks of gestation, restarted ≤1 month postpartum) or conservative (NAT-C; continued ≤4 weeks of gestation, restarted >1 month postpartum) strategies, dimethyl fumarate (DMF) or low-efficacy DMTs (interferon-beta, glatiramer acetate). Annualized relapse rates (ARRs) were calculated for 12-month prepregnancy, pregnancy, and 6-month postpartum periods. RESULTS: A total of 2,009 live births from 1,744 women were analyzed, including 73 live births from 69 women treated with preconception OCR. For OCR, no within-pregnancy relapse was observed and 3 women (4.1%) experienced 1 relapse in the postpartum period (ARR 0.09 [95% CI 0.02-0.27]). For NAT-A, 3 (3.7%) of 82 women relapsed during pregnancy (0.05 [0.01-0.15]) and 4 (4.9%) relapsed during postpartum (0.10 [0.03-0.26]). However, for NAT-C, 13 (15.9%) of 82 women relapsed within pregnancy (0.32 [0.20-0.51]) and 25 (30.5%) relapsed during postpartum (0.74 [0.50-1.06]). In the low-efficacy DMT group, 101 (7.6%) of 1,329 women experienced within-pregnancy relapse (0.12 [0.10-0.14]), followed by an increase in postpartum relapse activity with 234 women (17.6%) relapsing (0.43 [0.38-0.48]). This was similarly seen in the DMF group with 13 (7.9%) of 164 women experiencing within-pregnancy relapse (0.12 [0.06-0.20]) and 25 (15.2%) of 164 relapsing postpartum (0.39 [0.26-0.57]). Our RTX cohort had 0 of 24 women experiencing within-pregnancy relapse and 3 (12.5%) of 24 experiencing postpartum relapse. DISCUSSION: Women treated with OCR or NAT-A were observed to have low relapse rates during pregnancy and postpartum. NAT-C was associated with increased risk of relapses. There was no within-pregnancy relapse in our RTX cohort, although we caution overinterpretation due to our sample size. An effective DMT strategy with a favorable safety profile for the mother and infant should be discussed and implemented well in advance of planning a family. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that for women with relapsing-remitting MS or clinically isolated syndrome who become pregnant, ocrelizumab, rituximab, and natalizumab (continued ≥28 weeks of gestation and restarted ≤1 month postpartum) were associated with reduced risk of relapses, compared with other therapeutic strategies.

MeSH
dospělí MeSH
humanizované monoklonální protilátky * farmakologie aplikace a dávkování MeSH
imunologické faktory * farmakologie aplikace a dávkování MeSH
komplikace těhotenství * farmakoterapie MeSH
lidé MeSH
mladý dospělý MeSH
poporodní období * MeSH
registrace MeSH
relabující-remitující roztroušená skleróza farmakoterapie MeSH
retrospektivní studie MeSH
roztroušená skleróza farmakoterapie MeSH
těhotenství MeSH
Check Tag
dospělí MeSH
lidé MeSH
mladý dospělý MeSH
těhotenství MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH

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