Mammalian female gametes frequently suffer from numerical chromosomal aberrations, the main cause of miscarriages and severe developmental defects. The underlying mechanisms responsible for the development of aneuploidy in oocytes are still not completely understood and remain a subject of extensive research. From studies focused on prevalence of aneuploidy in mouse oocytes, it has become obvious that reported rates of aneuploidy are strongly dependent on the method used for chromosome counting. In addition, it seems likely that differences between mouse strains could influence the frequency of aneuploidy as well; however, up till now, such a comparison has not been available. Therefore, in our study, we measured the levels of aneuploidy which has resulted from missegregation in meiosis I, in oocytes of three commonly used mouse strains-CD-1, C3H/HeJ, and C57BL/6. Our results revealed that, although the overall chromosomal numerical aberration rates were similar in all three strains, a different number of oocytes in each strain contained prematurely segregated sister chromatids (PSSC). This indicates that a predisposition for this type of chromosome segregation error in oocyte meiosis I is dependent on genetic background.
- MeSH
- aneuploidie MeSH
- chromatidy genetika MeSH
- meióza genetika MeSH
- myši inbrední C3H MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- oocyty cytologie MeSH
- počet buněk MeSH
- polární tělísko metabolismus MeSH
- segregace chromozomů genetika MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Klíčová slova
- kontrolní bod sestavení dělicího vřeténka,
- MeSH
- aneuploidie * MeSH
- buněčný cyklus MeSH
- chromatidy MeSH
- chromozomální poruchy MeSH
- dělení bunečného jádra MeSH
- lidé MeSH
- oocyty * fyziologie MeSH
- oogeneze MeSH
- Check Tag
- lidé MeSH
