The ability to manipulate the structure and function of promising systems via external stimuli is emerging with the development of reconfigurable and programmable multifunctional materials. Increasing antifungal and antitumor activity requires novel, effective treatments to be diligently sought. In this work, the synthesis, characterization, and in vitro biological screening of pure α-Ag2WO4, irradiated with electrons and with non-focused and focused femtosecond laser beams are reported. We demonstrate, for the first time, that Ag nanoparticles/α-Ag2WO4 composite displays potent antifungal and antitumor activity. This composite had an extreme low inhibition concentration against Candida albicans, cause the modulation of α-Ag2WO4 perform the fungicidal activity more efficient. For tumor activity, it was found that the composite showed a high selectivity against the cancer cells (MB49), thus depleting the populations of cancer cells by necrosis and apoptosis, without the healthy cells (BALB/3T3) being affected.

• MeSH
• Antifungal Agents pharmacology   MeSH
• Apoptosis MeSH
• BALB 3T3 Cells MeSH
• Candida albicans drug effects   MeSH
• Electrons * MeSH
• Metal Nanoparticles administration & dosage   chemistry   radiation effects   MeSH
• Humans MeSH
• Mice MeSH
• Tumor Cells, Cultured MeSH
• Urinary Bladder Neoplasms drug therapy   pathology   MeSH
• Oxides chemistry   radiation effects   MeSH
• Cell Proliferation MeSH
• Antineoplastic Agents pharmacology   MeSH
• Silver chemistry   radiation effects   MeSH
• Tungsten chemistry   radiation effects   MeSH
• Xenograft Model Antitumor Assays MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Mice MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH