- MeSH
- frambézie epidemiologie mikrobiologie veterinární MeSH
- fylogeneze MeSH
- lidé MeSH
- nemoci primátů epidemiologie mikrobiologie MeSH
- primáti MeSH
- Treponema pallidum genetika izolace a purifikace fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- dopisy MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- subsaharská Afrika MeSH
BACKGROUND: Recently, the World Health Organization launched a campaign to eradicate the tropical disease yaws, caused by the bacterium Treponema pallidum subsp. pertenue; however, for decades researchers have questioned whether flies act as a vector for the pathogen that could facilitate transmission. METHODS: A total of 207 fly specimens were trapped in areas of Africa in which T. pallidum-induced skin ulcerations are common in wild baboons; 88 flies from Tarangire National Park and 119 from Lake Manyara National Park in Tanzania were analyzed by PCR for the presence of T. pallidum DNA. FINDINGS: We report that in the two study areas, T. pallidum DNA was found in 17-24% of wild-caught flies of the order Diptera. Treponemal DNA sequences obtained from many of the flies match sequences derived from nearby baboon T. pallidum strains, and one of the fly species with an especially high prevalence of T. pallidum DNA, Musca sorbens, has previously been shown to transmit yaws in an experimental setting. INTERPRETATION: Our results raise the possibility that flies play a role in yaws transmission; further research is warranted, given how important understanding transmission is for the eradication of this disfiguring disease.
- MeSH
- bakteriální geny MeSH
- Diptera klasifikace mikrobiologie MeSH
- DNA bakterií * MeSH
- ekosystém * MeSH
- fylogeneze MeSH
- hmyz - vektory mikrobiologie MeSH
- mikrobiologie životního prostředí MeSH
- Papio mikrobiologie MeSH
- sekvenční analýza DNA MeSH
- Treponema genetika MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Afrika MeSH
- Tanzanie MeSH
