- Publikační typ
- abstrakt z konference MeSH
AIM: Monitoring of anthracycline-induced cardiotoxicity with electrocardiography (ECG) and comparing ECG changes with findings on echocardiography (ECHO). METHODS: A total of 26 adult acute leukemia patients (mean age 46.2 -/+ 12.4 years, 15 males) treated with 2-6 cycles of anthracycline-based chemotherapy (CT) were studied. Cardiac evaluation was performed at the baseline (before CT), after first CT, after last CT (cumulative anthracycline dose 464.3 -/+ 117.5 mg/m2) and circa 6 months after CT. Time ECG parameters, QRS voltage, presence of repolarization changes, arrhythmias and other abnormalities were evaluated. RESULTS: During treatment and follow-up, we found a statistical significant QTc interval prolongation - 414.7 -/+ 16.0 ms (before CT), 419.6 -/+ 21.6 ms (after first CT), 428.0 -/+ 16.2 ms (after last CT) and 430.1 -/+ 18.4 ms (6 months after CT). Significant QTc interval prolongation (> 450 ms) occurred in 3 patients after first CT, in 4 patients after last CT and in 5 patients within 6 months after CT. Significant total QRS voltage lowering in the limb leads (> 1.0 mV versus before CT) occurred in 3 patients after first CT, in 5 patients after last CT and in 6 patients within 6 months after CT. We found a statistically significant correlation between decreased QRS voltage, QTc interval prolongation and left ventricular (LV) dysfunction on ECHO. Repolarization changes associated with oncology treatment were present in 9 patients within 6 months after CT. CONCLUSION: Anthracycline treatment is associated with changes in electrical activity of the myocardium. Prolonged QTc interval represents a risk for development of malignant ventricular arrhythmias. Decreased QRS voltage and prolonged QTc interval after anthracycline treatment could correlate with LV dysfunction on ECHO. Further studies will be needed to prove whether these ECG changes could serve as an accessible and non-invasive screening method indicating LV dysfunction after anthracycline treatment.
- MeSH
- antitumorózní látky škodlivé účinky MeSH
- antracykliny škodlivé účinky MeSH
- dospělí MeSH
- echokardiografie MeSH
- elektrokardiografie MeSH
- leukemie farmakoterapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- protokoly antitumorózní kombinované chemoterapie škodlivé účinky MeSH
- srdce účinky léků MeSH
- srdeční arytmie diagnóza chemicky indukované MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- klinické zkoušky MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
Počet diabetiků každoročně stoupá, proto jistě stoupá i počet diabetiků navštěvujících kožní ambulance. Tento článek z pohledu diabetologa poukazuje na zvláštnosti kožních infekcí u diabetiků ve snaze zvýšit účinnost dermatologické léčby s ohledem na přidružené metabolické a patofyziologické souvislosti. Speciální pozornost je věnována diagnostice a léčbě infekce u syndromu diabetické nohy, protože jen časná a komplexní léčba může být úspěšná.
A number of diabetic patients grows every year. That is the reason why the number of diabetic patients visiting dermatology clinic grows as well. This article points out specific features of skin infection in diabetics in an effort to increase efficiency of dermatology treatment. A special attention is paid to the problem of diagnosis and treatment of diabetic foot infection, since only early and complex treatment may be successful.
