57 infants were examined at age from 0 to 15 months with congenital clefts. Operative-medical actions were conducted after the checkup of infant depending on degree of deformation. 16 practically sound infants of the similar age formed the control group. Study of cytokine levels for IL-1, TNF, IFNγ in blood serum was made using IFA method. Received results showed that increasing level of pro-inflammatory cytokines was observed under congenital cleft. Depth of broken level depends on clinical form of congenital clefts. The most deflection was observed on infants with congenital double-sided cleft lip and palate (CCLP-2). The noted changes on condition of cytokine status on infants with congenital cleft lip and palate led to qualifying the secondary immunodeficient condition, requiring undertaking immunomodulating actions.
- MeSH
- biochemická analýza krve * MeSH
- cytokiny fyziologie MeSH
- imunitní systém - jevy fyziologie MeSH
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- rozštěp patra * chirurgie imunologie MeSH
- rozštěp rtu * chirurgie imunologie MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
The material on registration of malformation has been studied in Bukhara region for 2010. Out of 159 infants, born with different intrauterine anomalies the 16.35% (26) were found with the cleft lip and palate in different variants. After the complex examination by specialists (surgeon, pediatrician, orthopedist, otolaryngologist, psychoneurologist) operative treatment was conducted depending on degree of the defect. The study of the condition of immune system in infants was conducted after operative treatment. The examined were divided into 2 groups - infants without postoperative complications and infants with postoperative complications. We studied the quantitative determination of lymphocytes with phenotype CD3, CD4, CD8, CD16, concentration IgG, IgA IgM, phagocytic activity of neutrophils and the level of CIA. It was found that in infants with congenital cleft lip and palate exist the deflections on the condition of immune system, which were more denominated in infants with postoperative complications.
- MeSH
- biochemická analýza krve * MeSH
- imunitní systém - jevy MeSH
- imunitní systém MeSH
- imunoglobulinové izotypy MeSH
- imunokomplex MeSH
- lidé MeSH
- novorozenec MeSH
- pooperační komplikace MeSH
- rozštěp patra chirurgie MeSH
- rozštěp rtu chirurgie MeSH
- vrozené, dědičné a novorozenecké nemoci a abnormality * chirurgie imunologie MeSH
- Check Tag
- lidé MeSH
- novorozenec MeSH