57 infants were examined at age from 0 to 15 months with congenital clefts. Operative-medical actions were conducted after the checkup of infant depending on degree of deformation. 16 practically sound infants of the similar age formed the control group. Study of cytokine levels for IL-1, TNF, IFNγ in blood serum was made using IFA method. Received results showed that increasing level of pro-inflammatory cytokines was observed under congenital cleft. Depth of broken level depends on clinical form of congenital clefts. The most deflection was observed on infants with congenital double-sided cleft lip and palate (CCLP-2). The noted changes on condition of cytokine status on infants with congenital cleft lip and palate led to qualifying the secondary immunodeficient condition, requiring undertaking immunomodulating actions.
- MeSH
- biochemická analýza krve * MeSH
- cytokiny fyziologie MeSH
- imunitní systém - jevy fyziologie MeSH
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- rozštěp patra * chirurgie imunologie MeSH
- rozštěp rtu * chirurgie imunologie MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
