WHO Health Evidence Network synthesis report, ISSN 2227-4316 70
xx, 58 stran : grafy
- MeSH
- chování MeSH
- duševní zdraví MeSH
- genderová identita MeSH
- kultura MeSH
- muži MeSH
- mužskost MeSH
- socioekonomické faktory MeSH
- Konspekt
- Psychologie
- NLK Obory
- psychologie, klinická psychologie
- NLK Publikační typ
- publikace WHO
Background. Research interest in ceruloplasmin (CP) has significantly increased in recent years owing to new discoveries of its properties including anti-inflammatory and anti-oxidant effects. Data on CP blood plasma level in patients with herpetic infection caused by herpes simplex virus are scarce and often contradictory. Most point to a reduction of CP in the blood plasma of patients during the exacerbation of the disease with gradually return to normal values after treatment. There is evidence of an increase in CP levels during the acute period of CRHI (chronic recurrent herpes infection) and decrease in remission. Materials and methods. The content of ceruloplasmin in blood plasma was determined by immunoturbidimetry using the test-systems “Spinreact” (Spain) and biochemical analyzer “Architect C8000”. Results. We found that in patients with severe forms of chronic recurrent herpes infection in the exacerbation period, CP levels were increased by approximately 35% relative to the control values. However in the remission period in 80% of patients, CP concentrations remained elevated and in some patients the CP level was even increased in comparison with values in the exacerbation. Such dynamics of CP were not caused by the exacerbation of concomitant diseases. Conclusion. The increased CP levels in the remission period in patients with severe forms of chronic recurrent herpes infection may have been caused by its effect as an endogenous antioxidant. No correlations of CP levels with other laboratory signs of acute inflammation were found but identified was a relation to free radical activity.
AIM: The propensity for certain individuals to develop staphylococcal recurrent furunculosis (RF) is not fully understood. But among the reasons of its development the immune system dysfunctions are described. As in the staphylococcus elimination the main role is played by neutrophils, the objective of this study was to determine nitric oxide (NO) and reactive oxygen species (ROS) production by polymo rphonuclear leukocytes (PMNs) of patients with RF and to compare them with the response of normal cells to stimulation. MATERIALS AND METHODS: The spontaneous and pyrogenal-stimulated nitric oxide production was evaluated in leukocyte cell cultures by Griess reaction, and ROS generation was determined in the stimulated and unstimulated NBT-test. RESULTS: In this study we have demonstrated that leukocytes of healthy subjects respond on stimulation by the increase of both NO and ROS production. In contrast, leukocytes of patients with RF react by depression of NO formation at stimulation, and are characterized by decrease of ROS production reserve with the increasing of spontaneous ROS generation. Described disorders are revealed in the remission period as well as at exacerbation of furunculosis. CONCLUSION: The present study suggests that leukocytes of patients with RF have stable defect of stimulated NO production increase, which can be the reason for recurrent and severe course of furunculosis.
- MeSH
- dospělí MeSH
- fagocytóza MeSH
- furunkulóza metabolismus MeSH
- kultivované buňky MeSH
- lidé středního věku MeSH
- lidé MeSH
- lipopolysacharidy farmakologie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- neutrofily metabolismus účinky léků MeSH
- oxid dusnatý biosyntéza MeSH
- reaktivní formy kyslíku metabolismus MeSH
- recidiva MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
