In this study we analyzed the effects of melatonin (Mel, 1 mg/kg ip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations.
- MeSH
- Antidepressive Agents administration & dosage pharmacology MeSH
- Antioxidants administration & dosage pharmacology MeSH
- Apoptosis drug effects MeSH
- Olfactory Bulb surgery MeSH
- Behavior, Animal drug effects MeSH
- Glutathione metabolism MeSH
- Glutathione Peroxidase metabolism MeSH
- Injections, Intraperitoneal MeSH
- Caspase 3 metabolism MeSH
- Rats MeSH
- L-Lactate Dehydrogenase metabolism MeSH
- Melatonin administration & dosage pharmacology MeSH
- Brain metabolism pathology drug effects MeSH
- Oxidative Stress drug effects MeSH
- Lipid Peroxidation drug effects MeSH
- Swimming MeSH
- Motor Activity drug effects MeSH
- Rats, Wistar MeSH
- Superoxide Dismutase metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
