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Autor: Pieper, Tom

3 záznamů v Medvik Filtry

Článek

Outcome of Epilepsy Surgery in MRI-Negative Patients Without Histopathologic Abnormalities in the Resected Tissue

Sanders, Maurits W
Autor Sanders, Maurits W ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Van der Wolf, Iskander
Autor Van der Wolf, Iskander ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Jansen, Floor E
Autor Jansen, Floor E ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Aronica, Eleonora
Autor Aronica, Eleonora ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Helmstaedter, Christoph
Autor Helmstaedter, Christoph ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Racz, Attila
Autor Racz, Attila ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Surges, Rainer
Autor Surges, Rainer ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Grote, Alexander
Autor Grote, Alexander ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Becker, Albert J
Autor Becker, Albert J ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Rheims, Sylvain
Autor Rheims, Sylvain ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany

Neurology. 2024 ; 102 (4) : e208007. [pub] 20240130

ISSN 1526-632X
Medvik
Zdroj

BACKGROUND AND OBJECTIVE: Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared with lesional patients. In this study, we aimed to characterize a large group of patients with focal epilepsy who underwent epilepsy surgery despite a normal MRI and had no lesion on histopathology. Determinants of their postoperative seizure outcomes were further studied. METHODS: We designed an observational multicenter cohort study of MRI-negative and histopathology-negative patients who were derived from the European Epilepsy Brain Bank and underwent epilepsy surgery between 2000 and 2012 in 34 epilepsy surgery centers within Europe. We collected data on clinical characteristics, presurgical assessment, including genetic testing, surgery characteristics, postoperative outcome, and treatment regimen. RESULTS: Of the 217 included patients, 40% were seizure-free (Engel I) 2 years after surgery and one-third of patients remained seizure-free after 5 years. Temporal lobe surgery (adjusted odds ratio [AOR]: 2.62; 95% CI 1.19-5.76), shorter epilepsy duration (AOR for duration: 0.94; 95% CI 0.89-0.99), and completely normal histopathologic findings-versus nonspecific reactive gliosis-(AOR: 4.69; 95% CI 1.79-11.27) were significantly associated with favorable seizure outcome at 2 years after surgery. Of patients who underwent invasive monitoring, only 35% reached seizure freedom at 2 years. Patients with parietal lobe resections had lowest seizure freedom rates (12.5%). Among temporal lobe surgery patients, there was a trend toward favorable outcome if hippocampectomy was part of the resection strategy (OR: 2.94; 95% CI 0.98-8.80). Genetic testing was only sporadically performed. DISCUSSION: This study shows that seizure freedom can be reached in 40% of nonlesional patients with both normal MRI and histopathology findings. In particular, nonlesional temporal lobe epilepsy should be regarded as a relatively favorable group, with almost half of patients achieving seizure freedom at 2 years after surgery-even more if the hippocampus is resected-compared with only 1 in 5 nonlesional patients who underwent extratemporal surgery. Patients with an electroclinically identified focus, who are nonlesional, will be a promising group for advanced molecular-genetic analysis of brain tissue specimens to identify new brain somatic epilepsy genes or epilepsy-associated molecular pathways.

MeSH
elektroencefalografie MeSH
epilepsie parciální * diagnostické zobrazování chirurgie MeSH
epilepsie temporálního laloku * chirurgie MeSH
epilepsie * diagnostické zobrazování chirurgie MeSH
kohortové studie MeSH
lidé MeSH
magnetická rezonanční tomografie MeSH
retrospektivní studie MeSH
výsledek terapie MeSH
záchvaty MeSH
Check Tag
lidé MeSH
Publikační typ
časopisecké články MeSH
multicentrická studie MeSH
pozorovací studie MeSH

Článek online

Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

The New England journal of medicine. 2017 ; 377 (17) : 1648-1656.

N Engl J Med
ISSN 1533-4406
Medvik
Zdroj

BACKGROUND: Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. METHODS: We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%). RESULTS: The onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4% of the patients (88.7% of cases were in adults), tumors (mainly ganglioglioma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia was the most common type, 52.7% of cases of which were in children). No histopathological diagnosis could be established for 7.7% of the patients. CONCLUSIONS: In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.).

MeSH
databáze jako téma MeSH
dítě MeSH
dospělí MeSH
epilepsie etiologie patologie chirurgie MeSH
hipokampus patologie MeSH
lidé MeSH
malformace mozkové kůry komplikace patologie MeSH
mozek patologie MeSH
nádory mozku komplikace patologie MeSH
spánkový lalok patologie MeSH
věk při počátku nemoci MeSH
věkové faktory MeSH
Check Tag
dítě MeSH
dospělí MeSH
lidé MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
Geografické názvy
Evropa MeSH

Článek online

Different presurgical characteristics and seizure outcomes in children with focal cortical dysplasia type I or II

Epilepsia. 2009 ; 50 (1) : 125-137.

Medvik
Zdroj

PURPOSE: Cortical dysplasia (FCD) is a frequent cause of epilepsy in childhood. Two major pathological variants are distinguished, FCD type I and II. The aim of the study was to characterize differences between FCD type I and II with respect to imaging and EEG findings, clinical and neuropsychological presentations, and surgical outcome. METHODS: Forty children with refractory epilepsy and histopathologically confirmed FCD were retrospectively analyzed. FCD type I was identified in 24 and FCD type II in 16 patients. RESULTS: Characteristic MRI abnormalities in FCD type I included subtle white matter signal changes and regional reduction of the white matter volume. Typical MRI findings in FCD type II were increased cortical thickness, transmantle sign, gray-white matter junction blurring, fluid-attenuated inversion recovery (FLAIR) and proton density (PD) gray matter signal changes as well as T1w, and PD white matter signal changes. Continuous EEG slowing was significantly more common in patients with FCD type I. Children with FCD type I presented with lower levels of intelligence and were suffering more often from maladaptive behavior and behavioral disorders. Surgical outcome was significantly worse in the FCD type I group (seizure freedom was achieved in 21% FCD type I patients and in 75% FCD type II subjects, p < 0.001). CONCLUSIONS: Clinically important differences were found in children with distinct histopathological subtypes of FCD. Due to prominent neuropsychological deficits and worse seizure outcome, treatment strategies in FCD type I are more challenging than previously reported and these children should be recognized and specifically addressed within the incoherent group of patients with malformative brain disorders.

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