Introduction: The present study aimed to investigate the association between the five-factor personality model (FFM), physical fitness, and physical activity (PA), and the effect of firefighting skills training on physical condition in firefighter recruits. Methods: Data on 58 newly-recruited firefighters from the CELSPAC–FIREexpo human biomonitoring study were used. The sampling protocol was structured in the entry phase testing on the 5th week of training, and final testing on the 10th week of training. During the testing, participants filled out the International Physical Activity Questionnaire (IPAQ) and the Revised NEO Personality Inventory, and underwent analysis of body composition using Dual energy X-Ray Absorptiometry (DXA), a physical work capacity test (PWC 170), a muscular strength test (one repetition maximum bench press (1RM BP) and squat (1RM S)) and the measurement of body weight and height to calculate body mass index (BMI). Associations between study parameters were determined using the Spearman correlation. Results: Extraversion (E) was positively associated with time spent in vigorous physical activity (VPA) and Openness to Experience (O) was negatively associated with time spent sitting. Openness to Experience was also positively associated with BMI and lean mass differences between entry and output measurements. Furthermore, 1 RM S significantly increased during the training program. Conclusion: The observed association between personality from FFM and PA levels in the present study was lower than in the general population reported by other studies. The positive association between E and VPA suggests that using FFM and the relationship between personality and physical fitness as one of the criteria for the selection of suitable recruits may be beneficial.

INTRODUCTION: Benzotriazoles and benzothiazoles (BTs) are high-production volume chemicals as well as widely distributed emerging pollutants with potential health risk. However, information about human exposure to BTs and associated health outcomes is limited. OBJECTIVE: We aimed to characterise exposure to BTs among Czech men, including possible occupational exposure among firefighters, its predictors, and its associations with liver function, serum lipids and oxidative stress. METHODS: 165 participants (including 110 firefighters) provided urine and blood samples that were used to quantify the urinary levels of 8 BTs (high-performance liquid chromatography-tandem mass spectrometry), and 4 liver enzymes, cholesterol, low-density lipoprotein, and 8-hydroxy-2'-deoxyguanosine. Linear regression was used to assess associations with population characteristics and biomarkers of liver function, serum lipids and oxidative stress. Regression models were adjusted for potential confounding variables and false discovery rate procedure was applied to account for multiplicity. RESULTS: The BTs ranged from undetected up to 46.8 ng/mL. 2-hydroxy-benzothiazole was the most predominant compound (detection frequency 83%; median 1.95 ng/mL). 1-methyl-benzotriazole (1M-BTR) was measured in human samples for the first time, with a detection frequency 77% and median 1.75 ng/mL. Professional firefighters had lower urinary 1M-BTR compared to non-firefighters. Urinary 1M-BTR was associated with levels of γ-glutamyl transferase (β = - 17.54%; 95% CI: - 26.127, - 7.962). CONCLUSION: This is the first study to investigate BT exposure in Central Europe, including potentially exposed firefighters. The findings showed a high prevalence of BTs in the study population, the relevance of 1M-BTR as a new biomarker of exposure, and an urgent need for further research into associated adverse health outcomes.

• MeSH
• 8-hydroxy-2'-deoxyguanosin moč   krev   MeSH
• benzothiazoly * MeSH
• biologické markery * krev   moč   MeSH
• cholesterol krev   MeSH
• deoxyguanosin analogy a deriváty   moč   krev   MeSH
• dospělí MeSH
• hasiči MeSH
• játra účinky léků   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lipidy krev   MeSH
• oxidační stres * účinky léků   MeSH
• pracovní expozice * analýza   MeSH
• triazoly * MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH

INTRODUCTION: Firefighting is one of the most hazardous occupations due to exposure to per- and polyfluoroalkyl substances (PFAS) and polycyclic aromatic hydrocarbons (PAHs). Such exposure is suspected to affect the cardiometabolic profile, e.g., liver function and serum lipids. However, only a few studies have investigated the impact of this specific exposure among firefighters. METHODS: Men included in the CELSPAC-FIREexpo study were professional firefighters (n = 52), newly recruited firefighters in training (n = 58), and controls (n = 54). They completed exposure questionnaires and provided 1-3 samples of urine and blood during the 11-week study period to allow assessment of their exposure to PFAS (6 compounds) and PAHs (6 compounds), and to determine biomarkers of liver function (alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and total bilirubin (BIL)) and levels of serum lipids (total cholesterol (CHOL), low-density lipoprotein cholesterol (LDL) and triglycerides (TG)). The associations between biomarkers were investigated both cross-sectionally using multiple linear regression (MLR) and Bayesian weighted quantile sum (BWQS) regression and prospectively using MLR. The models were adjusted for potential confounders and false discovery rate correction was applied to account for multiplicity. RESULTS: A positive association between exposure to PFAS and PAH mixture and BIL (β = 28.6%, 95% CrI = 14.6-45.7%) was observed by the BWQS model. When the study population was stratified, in professional firefighters and controls the mixture showed a positive association with CHOL (β = 29.5%, CrI = 10.3-53.6%) and LDL (β = 26.7%, CrI = 8.3-48.5%). No statistically significant associations with individual compounds were detected using MLR. CONCLUSIONS: This study investigated the associations between exposure to PFAS and PAHs and biomarkers of cardiometabolic health in the Czech men, including firefighters. The results suggest that higher exposure to a mixture of these compounds is associated with an increase in BIL and the alteration of serum lipids, which can result in an unfavourable cardiometabolic profile.

• MeSH
• Bayesova věta MeSH
• biologické markery moč   MeSH
• fluorokarbony * MeSH
• hasiči * MeSH
• játra chemie   MeSH
• kardiovaskulární nemoci * MeSH
• lidé MeSH
• lipidy MeSH
• polycyklické aromatické uhlovodíky * moč   MeSH
• pracovní expozice * analýza   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH