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Center for Developmental Biology and ... 1 Department of Biomedical Sciences Uni... 1 Department of Biophysics 2nd Faculty ... 1 Department of Medical Surgical and Ex... 1 Department of Medicine Surgery and Ph... 1 Fraunhofer Institute for Biomedical E... 1 Laboratory of Molecular Biology and S... 1 R and D Laboratory Center InoCure s r... 1 University Centre for Energy Efficien... 1
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Pracoviště
Center for Developmental Biology and ... 1 Department of Biomedical Sciences Uni... 1 Department of Biophysics 2nd Faculty ... 1 Department of Medical Surgical and Ex... 1 Department of Medicine Surgery and Ph... 1 Fraunhofer Institute for Biomedical E... 1 Laboratory of Molecular Biology and S... 1 R and D Laboratory Center InoCure s r... 1 University Centre for Energy Efficien... 1
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- Serra, Diletta
- Garroni, Giuseppe
- Cruciani, Sara
- Coradduzza, Donatella
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Pashchenko, Aleksei
Autor Pashchenko, Aleksei ORCID Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy Department of Biophysics, Second Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague, Czech Republic University Centre for Energy Efficient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43 Bustehrad, Czech Republic
- Amler, Evzen
- Pintore, Giorgio
- Satta, Rosanna
- Montesu, Maria Antonietta
- Kohl, Yvonne
Free Medical Journals od 2000
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PubMed
38339184
DOI
10.3390/ijms25031908
Knihovny.cz E-zdroje
The skin is the primary tissue affected by wounds and aging, significantly impacting its protective function. Natural products are widely used in cosmetics, representing a new approach to preventing age-related damage. Nanomedicine combines nanotechnology and traditional treatments to create innovative drugs. The main targets of nanotechnological approaches are wound healing, regeneration, and rejuvenation of skin tissue. The skin barrier is not easily permeable, and the creation of modern nanodevices is a way to improve the passive penetration of substances. In this study, Helichrysum italicum oil (HO) was combined with different types of electrospun nanofibers to study their protective activity on the skin and to evaluate their future application for topical treatments. In the present research, we used biodegradable polymers, including polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), which were characterized by a scanning electron microscope (SEM). All results show a positive trend in cell proliferation and viability of human skin stem cells (SSCs) and BJ fibroblasts pre-treated with combined nanofibers and then exposed to UV stress. Gene expression analysis revealed the activation of a molecular rejuvenation program in SSCs treated with functionalized nanofibers before UV exposure. Understanding the mechanisms involved in skin changes during aging allows for the future application of nanomaterials combined with HO directly to the patients.
- MeSH
- biologické přípravky * farmakologie MeSH
- hojení ran MeSH
- kůže MeSH
- lidé MeSH
- nanovlákna * MeSH
- polyvinylalkohol MeSH
- stárnutí kůže * MeSH
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