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1st Dermatovenereological Clinic St A... 1 CEITEC Central European Institute of ... 1 Department of Biology Faculty of Medi... 1 Department of Dermatovenerology Unive... 1 Department of Immunology Veterinary R... 1 Department of Medicine Division of Al... 1 Functional Genomics Center Zurich Uni... 1
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1st Dermatovenereological Clinic St A... 1 CEITEC Central European Institute of ... 1 Department of Biology Faculty of Medi... 1 Department of Dermatovenerology Unive... 1 Department of Immunology Veterinary R... 1 Department of Medicine Division of Al... 1 Functional Genomics Center Zurich Uni... 1
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PubMed
30130365
DOI
10.1371/journal.pone.0202619
Knihovny.cz E-zdroje
Treponema pallidum subsp. pallidum (TPA) is the infectious agent of syphilis, a disease that infects more than 5 million people annually. Since TPA is an uncultivable bacterium, most of the information on TPA genetics comes from genome sequencing and molecular typing studies. This study presents the first complete TPA genome (without sequencing gaps) of clinical isolate (UZ1974), which was obtained directly from clinical material, without multiplication in rabbits. Whole genome sequencing was performed using a newly developed Anti-Treponemal Antibody Enrichment technique combined with previously reported Pooled Segment Genome Sequencing. We identified the UW074B genome, isolated from a sample previously propagated in rabbits, to be the closest relative of the UZ1974 genome and calculated the TPA mutation rate as 2.8 x 10(-10) per site per generation.
- MeSH
- fylogeneze MeSH
- genetická variace MeSH
- genom bakteriální genetika MeSH
- králíci MeSH
- lidé MeSH
- mutační rychlost MeSH
- sekvenční analýza DNA MeSH
- sekvenování celého genomu * MeSH
- syfilis genetika mikrobiologie MeSH
- Treponema pallidum genetika patogenita MeSH
- zvířata MeSH
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- králíci MeSH
- lidé MeSH
- zvířata MeSH
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- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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