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Autor
Amant, Frederic 1 Arts, Martijn S J P 1 Bronsert, Peter 1 Bulten, Johan 1 Bussink, Johan 1 Colas, Eva 1 Gil-Moreno, Antonio 1 Haldorsen, Ingfrid S 1 Hirschfeld, Marc 1 Huvila, Jutta 1 Jandakova, Eva 1 Koskas, Martin 1 Krakstad, Camilla 1 Küsters-Vandevelde, Heidi V N 1 Mancebo, Gemma 1 Massuger, Leon F A G 1 Matias-Guiu, Xavier 1 Minar, Lubos 1 Peters, Johan P 1 Pijnenborg, Johanna M A 1
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Biomedical Research Group in Gynecolo... 1 Biomedical Research Group in Gynecolo... 1 Centre for Cancer Biomarkers Departme... 1 Department of Gynecology and Obstetri... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Oncology KU Leuven Leuv... 1 Department of Pathology Canisius Wilh... 1 Department of Pathology Ghent Univers... 1 Department of Pathology Radboud Unive... 1 Department of Pathology University of... 1 Department of Pathology and Molecular... 1 Department of Radiation Oncology Radb... 1 Institute of Pathology Faculty of Med... 1 Institute of Pathology University Med... 1
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Autor
Amant, Frederic 1 Arts, Martijn S J P 1 Bronsert, Peter 1 Bulten, Johan 1 Bussink, Johan 1 Colas, Eva 1 Gil-Moreno, Antonio 1 Haldorsen, Ingfrid S 1 Hirschfeld, Marc 1 Huvila, Jutta 1 Jandakova, Eva 1 Koskas, Martin 1 Krakstad, Camilla 1 Küsters-Vandevelde, Heidi V N 1 Mancebo, Gemma 1 Massuger, Leon F A G 1 Matias-Guiu, Xavier 1 Minar, Lubos 1 Peters, Johan P 1 Pijnenborg, Johanna M A 1
- Organizace
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Biomedical Research Group in Gynecolo... 1 Biomedical Research Group in Gynecolo... 1 Centre for Cancer Biomarkers Departme... 1 Department of Gynecology and Obstetri... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Oncology KU Leuven Leuv... 1 Department of Pathology Canisius Wilh... 1 Department of Pathology Ghent Univers... 1 Department of Pathology Radboud Unive... 1 Department of Pathology University of... 1 Department of Pathology and Molecular... 1 Department of Radiation Oncology Radb... 1 Institute of Pathology Faculty of Med... 1 Institute of Pathology University Med... 1
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Reijnen, Casper
Autor Reijnen, Casper Department of Obstetrics and Gynaecology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Casper.reijnen@radboudumc.nl. Department of Obstetrics and Gynaecology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands. Casper.reijnen@radboudumc.nl
- van Weelden, Willem Jan
- Arts, Martijn S J P
- Peters, Johan P
- Rijken, Paul F
- van de Vijver, Koen
- Santacana, Maria
- Bronsert, Peter
- Bulten, Johan
- Hirschfeld, Marc
NLK
Free Medical Journals
od 1947 do Před 1 rokem
Freely Accessible Journals
od 1947 do Před 1 rokem
PubMed Central
od 1947 do Před 1 rokem
Europe PubMed Central
od 1947 do Před 1 rokem
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1947-01-01
Open Access Digital Library
od 1999-01-01
Nursing & Allied Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
31011231
DOI
10.1038/s41416-019-0461-2
Knihovny.cz E-zdroje
BACKGROUND: Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. METHODS: Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed according to the Weidner method. Correlations with disease-specific survival (DSS), disease-free survival (DFS) and distant disease-free survival (DDFS) were calculated using Kaplan-Meier curves and Cox regression analysis. RESULTS: Sixty-three (16.4%) of 385 ECs showed positive CAIX expression with high vascular density. These ECs had a reduced DSS compared to tumours with either hypoxia or high vascular density (log-rank p = 0.002). Multivariable analysis showed that hypoxic tumours with high vascular density had a reduced DSS (hazard ratio [HR] 3.71, p = 0.002), DDFS (HR 2.68, p = 0.009) and a trend for reduced DFS (HR 1.87, p = 0.054). CONCLUSIONS: This study has shown that adverse outcome in hypoxic ECs is seen in the presence of high vascular density, suggesting an important role of angiogenesis in the metastatic process of hypoxic EC. Differential adjuvant treatment might be indicated for these patients.
- MeSH
- dospělí MeSH
- hypoxie buňky MeSH
- karboanhydrasa IX analýza MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory endometria krevní zásobení mortalita patologie MeSH
- patologická angiogeneze MeSH
- senioři nad 80 let MeSH
- senioři MeSH
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- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
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