BACKGROUND: Cardiac magnetic resonance (CMR) plays a major diagnostic role in acute myocarditis (AM) in children as biopsy is rarely performed in this age group. Contribution of standard echocardiography (ECHO) is limited in AM, but speckle tracking echocardiography (STE) quantitatively characterizes myocardial function, with good sensitivity for detecting subclinical left ventricular (LV) dysfunction and regional kinetics disorders beyond the site of inflammation. This work aimed to evaluate the diagnostic potential of STE as compared with CMR findings in pediatric patients with AM. METHODS: The study was conducted during 2022-2023. Troponin, electrocardiography, ECHO with STE, and CMR with early and late enhancement were performed on each patient. Affected heart segments were analyzed by both STE and CMR, and the correlation of the two methods was assessed. RESULTS: During the study period, 20 children were diagnosed with AM [14 boys, 6 girls; mean age 12 years (median 14)]. On ECHO, three patients had a deviation in LV biometry, and four patients had a mild systolic function disorder. STE showed at least one affected cardiac segment in all patients, most often the inferolateral segment (16/20; 80%). Of the 20 patients, STE showed a reduction in LV global longitudinal strain in 13 (65%) patients. In all patients, CMR identified an inflammatory focus, most frequently inferolateral (15/20; 75%). The strongest accordance between STE and CMR was observed for the involvement of anterolateral segments (k = 0.88) and the weakest for inferoseptal damage (k = 0.4). CONCLUSIONS: STE can provide important diagnostic information in pediatric patients with AM. This modality supports the detection of early regional edema and subclinical myocardial dysfunction and can determine the impairment severity. STE is non-invasive and repeatable without the need for special patient preparation or for general anesthesia.
- Publikační typ
- časopisecké články MeSH
- MeSH
- alely MeSH
- atopická dermatitida genetika MeSH
- bronchiální astma genetika MeSH
- celoroční alergická rýma genetika MeSH
- finanční podpora výzkumu jako téma MeSH
- lidé MeSH
- polymorfismus genetický MeSH
- případové studie organizací MeSH
- transportní proteiny genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- srovnávací studie MeSH
- MeSH
- alergie enzymologie epidemiologie genetika MeSH
- dítě MeSH
- hormony kůry nadledvin terapeutické užití MeSH
- lidé MeSH
- mladiství MeSH
- polymorfismus genetický MeSH
- synthasa oxidu dusnatého genetika MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- Geografické názvy
- Česká republika MeSH
- MeSH
- bronchopulmonální dysplazie farmakoterapie prevence a kontrola MeSH
- budesonid aplikace a dávkování MeSH
- dexamethason aplikace a dávkování MeSH
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- systémy cílené aplikace léků statistika a číselné údaje MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- MeSH
- pyl MeSH
- Geografické názvy
- Česká republika MeSH
- Slovenská republika MeSH
