The Purpose of present study was to investigate the effect of riboflavin/ultraviolet-A-induced collagen cross-linking (CXL) on central cornea, limbus and intraocular pressure (IOP). This was an animal experimental study. The right corneas of 10 rabbits were ultraviolet-A irradiated (3 mW/cm2 for 30 minutes) after de-epithelialization and instillation of 0.1% riboflavin / 20% Dextran drops. Left corneas served as controls. Samples were examined histologically one month postoperatively. Before and after treatment, IOP measurements were recorded bilaterally. At central cornea of eyes underwent CXL keratocyte repopulation, normal arrangement of collagen fibres and a statistically significant change in fibres diameter were detected, compared to controls. At limbus area, there were not any significant histological differences after CXL. There was no statistically significant difference between pre- and postoperative IOP in all eyes.
- MeSH
- fotosenzibilizující látky farmakologie MeSH
- kolagen chemie ultrastruktura MeSH
- králíci MeSH
- limbus corneae účinky léků účinky záření chirurgie ultrastruktura MeSH
- nitrooční tlak * účinky léků účinky záření MeSH
- reagencia zkříženě vázaná farmakologie MeSH
- riboflavin farmakologie MeSH
- rohovka účinky léků účinky záření chirurgie ultrastruktura MeSH
- ultrafialové záření * MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
