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Autor
Agathangelidis, Andreas 1 Anagnostopoulos, Achilles 1 Belessi, Chrysoula 1 Boudjogra, Myriam 1 Campo, Elias 1 Davi, Frederic 1 Francová, Hana 1 Ghia, Paolo 1 Groenen, Patricia 1 Hadzidimitriou, Anastasia 1 Karypidou, Maria 1 Lopez, Alba Navarro 1 Marantidou, Fotini 1 Papadaki, Theodora 1 Papadopoulos, Giorgos 1 Ponzoni, Maurilio 1 Pospíšilová, Šárka 1 Pott, Christiane 1 Rosenquist, Richard 1 Stalika, Evangelia 1
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Pracoviště
2 Medizinische Klinik und Poliklinik ... 1 Biological Hematology Service Hopital... 1 Department of Immunology Genetics and... 1 Department of Internal Medicine Hemat... 1 Department of Pathology Radboud Unive... 1 Hematology Department Nikea General H... 1 Hematology Department and HCT Unit G ... 1 Hematopathology Department Evangelism... 1 Information Technologies Institute CE... 1 Insititut d'investigacions biomèdique... 1 Institute of Applied Biosciences CERT... 1 Laboratory of B cell Neoplasia and Ly... 1 Pathology Unit and Unit of Lymphoid M... 1
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Autor
Agathangelidis, Andreas 1 Anagnostopoulos, Achilles 1 Belessi, Chrysoula 1 Boudjogra, Myriam 1 Campo, Elias 1 Davi, Frederic 1 Francová, Hana 1 Ghia, Paolo 1 Groenen, Patricia 1 Hadzidimitriou, Anastasia 1 Karypidou, Maria 1 Lopez, Alba Navarro 1 Marantidou, Fotini 1 Papadaki, Theodora 1 Papadopoulos, Giorgos 1 Ponzoni, Maurilio 1 Pospíšilová, Šárka 1 Pott, Christiane 1 Rosenquist, Richard 1 Stalika, Evangelia 1
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Pracoviště
2 Medizinische Klinik und Poliklinik ... 1 Biological Hematology Service Hopital... 1 Department of Immunology Genetics and... 1 Department of Internal Medicine Hemat... 1 Department of Pathology Radboud Unive... 1 Hematology Department Nikea General H... 1 Hematology Department and HCT Unit G ... 1 Hematopathology Department Evangelism... 1 Information Technologies Institute CE... 1 Insititut d'investigacions biomèdique... 1 Institute of Applied Biosciences CERT... 1 Laboratory of B cell Neoplasia and Ly... 1 Pathology Unit and Unit of Lymphoid M... 1
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Xochelli, Aliki
Autor Xochelli, Aliki Institute of Applied Biosciences, CERTH, Center for Research and Technology Hellas, Thessaloniki, Greece Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
- Sutton, Lesley-Ann
- Agathangelidis, Andreas
- Stalika, Evangelia
- Karypidou, Maria
- Marantidou, Fotini
- Lopez, Alba Navarro
- Papadopoulos, Giorgos
- Šupíková, Jana
- Groenen, Patricia
Digitální knihovna NLK
Plný text - Článek
Zdroj
NLK
Free Medical Journals
od 1925 do Před 1 rokem
Open Access Digital Library
od 1998-07-01
Elsevier Open Access Journals
od 2014-09-01 do Před 1 rokem
Elsevier Open Archive Journals
od 1998-07-01 do Před 1 rokem
PubMed
25843681
DOI
10.1016/j.ajpath.2015.02.006
Knihovny.cz E-zdroje
To further our understanding about antigen involvement in mantle cell lymphoma (MCL), we analyzed the expression levels of activation-induced cytidine deaminase (AID), a key player in B-cell responses to antigen triggering, in 133 MCL cases; assessed the functionality of AID by evaluating in vivo class switch recombination in 52 MCL cases; and sought for indications of ongoing antigen interactions by exploring intraclonal diversification within 14 MCL cases. The AID full-length transcript and the most frequent splice variants (AID-ΔE4a, AID-ΔE) were detected in 128 (96.2%), 96 (72.2%), and 130 cases (97.7%), respectively. Higher AID full-length transcript levels were significantly associated (P < 0.001) with lack of somatic hypermutation within the clonotypic immunoglobulin heavy variable (IGHV) genes. Median AID transcript levels were higher in lymph node material compared to cases in which peripheral blood was analyzed, implying that clonal behavior is influenced by the microenvironment. Switched tumor-derived IGHV-IGHD-IGHJ transcripts were identified in 5 of 52 cases (9.6%), all of which displayed somatic hypermutation and AID-mRNA expression. Finally, although most cases exhibited low levels of intraclonal diversification, analysis of the mutational activity revealed a precise targeting of somatic hypermutation indicative of an active, ongoing interaction with antigen(s). Collectively, these findings strongly allude to antigen involvement in the natural history of MCL, further challenging the notion of antigen naivety.
- MeSH
- B-lymfocyty imunologie metabolismus patologie MeSH
- cytidindeaminasa metabolismus MeSH
- lidé MeSH
- lymfom z plášťových buněk imunologie metabolismus patologie MeSH
- somatická hypermutace imunoglobulinových genů * MeSH
- variabilní oblast imunoglobulinu * MeSH
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- lidé MeSH
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- časopisecké články MeSH
- práce podpořená grantem MeSH
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