Four different polymorphs, A, C, D, and E, of succinobucol were isolated and characterized by means of solid-state nuclear magnetic resonance spectroscopy, single crystal and powder X-ray diffraction, differential scanning calorimetry, thermogravimetry, and attenuated total reflection-infrared spectroscopy. From a number of experiments, the same polymorphs (C, D, and E) and an equilibrium phase mixture B consisting of polymorphs C and D were repeatedly gained using different solvents or their mixtures. Although polymorph A was obtained directly from recrystallization only on few occasions, polymorphs C, D, and E proved to be metastable kinetic polymorphs, which slowly transform to a thermodynamically more stable form A during long-term storage. The single-crystal structures of polymorph C and D were determined by X-ray single-crystal diffraction.

• MeSH
• Calorimetry, Differential Scanning MeSH
• Crystallization MeSH
• Crystallography, X-Ray MeSH
• Magnetic Resonance Spectroscopy MeSH
• Models, Molecular MeSH
• Powder Diffraction MeSH
• Probucol analogs & derivatives   analysis   chemistry   MeSH
• Spectrophotometry, Infrared MeSH
• Thermogravimetry MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH