A series of 3-deazapurine ribonucleosides 5a-5l bearing diverse C-substituents (alkyl, aryl and heteroaryl) in the position 6 were prepared by Pd-catalyzed cross-coupling reactions of either free 6-chloro-3-deazapurine ribonucleoside 4 or its acetyl protected congener 3 followed by deprotection. An improved synthesis of the starting 4-chloro-1-(2,3,5-tri-O-acetyl-ß-D-ribofuranosyl)-1H-imidazo[4,5-c]pyridine (3) was developed by the application of Vorbrüggen glycosylation of silylated nucleobase with 1,2,3,5-tetra-O-acetyl-ß-D-ribofuranose (2). None of compounds 5a-5l showed any considerable cytostatic or antiviral activity.

• MeSH
• financování organizované MeSH
• protinádorové látky chemická syntéza   MeSH
• puriny farmakokinetika   chemická syntéza   MeSH
• ribonukleosidy farmakokinetika   fyziologie   chemická syntéza   MeSH
• vztahy mezi strukturou a aktivitou MeSH

• MeSH
• DNA MeSH
• Drosophila MeSH
• mutace fyziologie   MeSH
• ribonukleosidy fyziologie   MeSH
• thymus MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH