The impact of high-intensity exercise on disease progression and muscle contractile properties in experimental autoimmune encephalomyelitis (EAE) remains unclear. Control (CON) and EAE rats were divided into sedentary and exercise groups. Before onset (experiment 1, n=40) and after hindquarter paralysis (experiment 2, n=40), isokinetic foot extensor strength, cross sectional area (CSA) of tibialis anterior (TA), extensor digitorum longus (EDL) and soleus (SOL) and brain-derived neurotrophic factor (BDNF) levels were assessed. EAE reduced muscle fiber CSA of TA, EDL and SOL. In general, exercise was not able to affect CSA, whereas it delayed hindquarter paralysis peak. CON muscle work peaked and declined, while it remained stable in EAE. BDNF-responses were not affected by EAE or exercise. In conclusion, EAE affected CSA-properties of TA, EDL and SOL, which could, partly, explain the absence of peak work during isokinetic muscle performance in EAE-animals. However, exercise was not able to prevent muscle fiber atrophy.
- MeSH
- encefalomyelitida autoimunitní experimentální krev patologie patofyziologie MeSH
- kondiční příprava zvířat fyziologie MeSH
- kosterní svalová vlákna patologie fyziologie MeSH
- mozkový neurotrofický faktor krev MeSH
- náhodné rozdělení MeSH
- potkani inbrední LEW MeSH
- přijímání potravy MeSH
- progrese nemoci MeSH
- svalová síla MeSH
- tělesná hmotnost MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- demyelinizační nemoci enzymologie MeSH
- encefalomyelitida autoimunitní experimentální enzymologie patofyziologie patologie MeSH
- enzymy MeSH
- morčata MeSH
- mozek - chemie MeSH
- subcelulární frakce patofyziologie patologie MeSH
- svaly patofyziologie patologie MeSH
- synapse enzymologie patofyziologie MeSH
- zvířata MeSH
- Check Tag
- morčata MeSH
- mužské pohlaví MeSH
- zvířata MeSH
