3'-nucleases/nucleotidases of the S1-P1 family (EC 3.1.30.1) are single-strand-specific or non-specific zinc-dependent phosphoesterases present in plants, fungi, protozoan parasites, and in some bacteria. They participate in a wide variety of biological processes and their current biotechnological applications rely on their single-strand preference, nucleotide non-specificity, a broad range of catalytic conditions and high stability. We summarize the present and potential utilization of these enzymes in biotechnology and medicine in the context of their biochemical and structure-function properties. Explanation of unanswered questions for bacterial and trypanosomatid representatives could facilitate development of emerging applications in medicine.
- MeSH
- antitumorózní látky farmakologie MeSH
- biotechnologie metody MeSH
- cílená molekulární terapie metody MeSH
- endonukleasy specifické pro jednořetězcové nukleové kyseliny chemie genetika metabolismus farmakologie MeSH
- fungální proteiny chemie metabolismus MeSH
- interakce hostitele a patogenu MeSH
- lidé MeSH
- mutační analýza DNA metody MeSH
- nukleotidasy metabolismus MeSH
- substrátová specifita MeSH
- vztahy mezi strukturou a aktivitou MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
