The effects of acoustic waves on membrane structures, and any resulting consequences of this treatment on membrane subunit structures, remain poorly understood, as are the principals of related clinical effects. With a focus on morphological changes in the nuclear envelope, the current study presents detailed observations of membrane structures exposed to therapeutic ultrasound. Ultrasound treatment most commonly resulted in distinct changes in the distribution of nuclear pore complexes (NPCs) and mean NPC number per unit area after 30 min of repair, as well as alterations in NPC diameters on the protoplasmic face of fractured nuclear membranes after 10 min of repair. The greatest effects of ultrasound on nuclear envelope structure and NPCs were not to appear immediately, but became evident after repair processes were initiated. Results from the current study may contribute to the general view on the biophysical effects of therapeutic ultrasound on cell morphology and, particularly, the understanding of this effect in relation to the nuclear envelope.
- MeSH
- elektronová mikroskopie metody využití MeSH
- HL-60 buňky cytologie ultrasonografie MeSH
- intracelulární membrány ultrasonografie MeSH
- jaderný obal * ultrasonografie ultrastruktura MeSH
- jaderný pór ultrastruktura MeSH
- komplex proteinů jaderného póru * ultrastruktura MeSH
- kultivační techniky metody využití MeSH
- leptání mrazem metody využití MeSH
- lidé MeSH
- mikrofotografie MeSH
- struktury buněčného jádra ultrasonografie MeSH
- ultrasonografie metody škodlivé účinky využití MeSH
- ultrazvuková terapie * metody škodlivé účinky využití MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
