Tubera mulgentium (hrboly dojičů) jsou infekčním virovým kožním onemocněním. Původcem je virus paravakcinie, přenáší se přímým kontaktem z nakažených krav na člověka. Autoři popisují případ 50leté pacientky zaměstnané jako dojička v kravíně, u které se vyvinul na ruce dojičský hrbol. Diagnóza byla stanovena na základě anamnézy, klinického vzhledu a histologie. Léčba lokálními antiseptiky vedla k vyléčení během tří týdnů. Onemocnění bylo uznáno jako choroba z povolání. V článku je uveden stručný přehled poznatků o tomto onemocněni.

Tubera mulgentium (Milker´s nodules) is an infectious viral skin disease. It is caused by the paravaccinia virus, transmitted from infected cows to humans by direct contact. The authors describe a case of a 50-year-old patient working as a milker in a cowshed, who developed Milker´s nodules on her hand. The diagnosis was based on the patient´s history, clinical appearance and histology. Treatment with local antiseptics led to healing within 3 weeks. The disease was recognized as an occupational disease. The article provides a brief review of current knowledge about this disease.

• Keywords
• tubera mulgentium,
• MeSH
• Dermatitis, Occupational diagnosis   etiology   therapy   MeSH
• Adult MeSH
• Exanthema etiology   MeSH
• Upper Extremity pathology   MeSH
• Poxviridae Infections * diagnosis   etiology   therapy   MeSH
• Skin Diseases, Infectious diagnosis   etiology   therapy   MeSH
• Humans MeSH
• Animal Technicians MeSH
• Pseudocowpox Virus pathogenicity   MeSH
• Treatment Outcome MeSH
• Agriculture MeSH
• Zoonoses MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Female MeSH
• Publication type
• Case Reports MeSH

Subversion of the host immune system by viruses is often mediated by molecular decoys that sequester host proteins pivotal to mounting effective immune responses. The widespread mammalian pathogen parapox Orf virus deploys GIF, a member of the poxvirus immune evasion superfamily, to antagonize GM-CSF (granulocyte macrophage colony-stimulating factor) and IL-2 (interleukin-2), two pleiotropic cytokines of the mammalian immune system. However, structural and mechanistic insights into the unprecedented functional duality of GIF have remained elusive. Here we reveal that GIF employs a dimeric binding platform that sequesters two copies of its target cytokines with high affinity and slow dissociation kinetics to yield distinct complexes featuring mutually exclusive interaction footprints. We illustrate how GIF serves as a competitive decoy receptor by leveraging binding hotspots underlying the cognate receptor interactions of GM-CSF and IL-2, without sharing any structural similarity with the cytokine receptors. Our findings contribute to the tracing of novel molecular mimicry mechanisms employed by pathogenic viruses.

• MeSH
• Granulocyte-Macrophage Colony-Stimulating Factor chemistry   immunology   metabolism   MeSH
• HEK293 Cells MeSH
• Poxviridae Infections immunology   metabolism   virology   MeSH
• Host-Pathogen Interactions immunology   MeSH
• Interleukin-2 chemistry   immunology   metabolism   MeSH
• Crystallography, X-Ray MeSH
• Humans MeSH
• Models, Molecular MeSH
• Multiprotein Complexes chemistry   immunology   metabolism   MeSH
• Parapoxvirus immunology   metabolism   MeSH
• Protein Binding MeSH
• Viral Proteins chemistry   immunology   metabolism   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH